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Gene: MB21D1 |
Gene summary for MB21D1 |
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Gene information | Species | Human | Gene symbol | MB21D1 | Gene ID | 115004 |
Gene name | cyclic GMP-AMP synthase | |
Gene Alias | C6orf150 | |
Cytomap | 6q13 | |
Gene Type | protein-coding | GO ID | GO:0000018 | UniProtAcc | Q8N884 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
115004 | MB21D1 | P2T-E | Human | Esophagus | ESCC | 1.54e-28 | 5.76e-01 | 0.1177 |
115004 | MB21D1 | P4T-E | Human | Esophagus | ESCC | 1.39e-36 | 8.85e-01 | 0.1323 |
115004 | MB21D1 | P5T-E | Human | Esophagus | ESCC | 9.73e-36 | 9.66e-01 | 0.1327 |
115004 | MB21D1 | P8T-E | Human | Esophagus | ESCC | 1.86e-12 | 1.89e-01 | 0.0889 |
115004 | MB21D1 | P9T-E | Human | Esophagus | ESCC | 1.28e-08 | 6.12e-02 | 0.1131 |
115004 | MB21D1 | P10T-E | Human | Esophagus | ESCC | 1.31e-03 | -6.48e-02 | 0.116 |
115004 | MB21D1 | P11T-E | Human | Esophagus | ESCC | 4.75e-18 | 9.11e-01 | 0.1426 |
115004 | MB21D1 | P12T-E | Human | Esophagus | ESCC | 2.76e-04 | 2.26e-01 | 0.1122 |
115004 | MB21D1 | P15T-E | Human | Esophagus | ESCC | 2.71e-14 | 2.96e-01 | 0.1149 |
115004 | MB21D1 | P16T-E | Human | Esophagus | ESCC | 1.07e-05 | 3.37e-02 | 0.1153 |
115004 | MB21D1 | P17T-E | Human | Esophagus | ESCC | 8.61e-05 | 2.00e-01 | 0.1278 |
115004 | MB21D1 | P19T-E | Human | Esophagus | ESCC | 8.21e-03 | 2.31e-01 | 0.1662 |
115004 | MB21D1 | P20T-E | Human | Esophagus | ESCC | 1.72e-10 | 1.76e-01 | 0.1124 |
115004 | MB21D1 | P21T-E | Human | Esophagus | ESCC | 4.51e-24 | 6.52e-01 | 0.1617 |
115004 | MB21D1 | P23T-E | Human | Esophagus | ESCC | 6.15e-24 | 6.63e-01 | 0.108 |
115004 | MB21D1 | P24T-E | Human | Esophagus | ESCC | 1.44e-13 | 3.48e-01 | 0.1287 |
115004 | MB21D1 | P26T-E | Human | Esophagus | ESCC | 9.14e-35 | 7.13e-01 | 0.1276 |
115004 | MB21D1 | P27T-E | Human | Esophagus | ESCC | 7.26e-23 | 5.99e-01 | 0.1055 |
115004 | MB21D1 | P28T-E | Human | Esophagus | ESCC | 8.22e-14 | 4.15e-01 | 0.1149 |
115004 | MB21D1 | P30T-E | Human | Esophagus | ESCC | 7.19e-03 | 1.66e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0516318 | Cervix | CC | Human cytomegalovirus infection | 65/1267 | 225/8465 | 4.59e-08 | 6.47e-07 | 3.83e-07 | 65 |
hsa0513120 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
hsa0517016 | Cervix | CC | Human immunodeficiency virus 1 infection | 55/1267 | 212/8465 | 1.80e-05 | 1.42e-04 | 8.40e-05 | 55 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0516319 | Cervix | CC | Human cytomegalovirus infection | 65/1267 | 225/8465 | 4.59e-08 | 6.47e-07 | 3.83e-07 | 65 |
hsa05131110 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
hsa0517017 | Cervix | CC | Human immunodeficiency virus 1 infection | 55/1267 | 212/8465 | 1.80e-05 | 1.42e-04 | 8.40e-05 | 55 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MB21D1 | SNV | Missense_Mutation | novel | c.1543N>C | p.Glu515Gln | p.E515Q | Q8N884 | protein_coding | tolerated(0.17) | benign(0.003) | TCGA-34-8454-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
MB21D1 | SNV | Missense_Mutation | c.1309C>G | p.His437Asp | p.H437D | Q8N884 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-56-8307-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MB21D1 | SNV | Missense_Mutation | novel | c.464N>T | p.Arg155Leu | p.R155L | Q8N884 | protein_coding | tolerated(0.15) | benign(0.02) | TCGA-85-6561-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
MB21D1 | SNV | Missense_Mutation | novel | c.721N>A | p.Glu241Lys | p.E241K | Q8N884 | protein_coding | deleterious(0.03) | probably_damaging(0.982) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MB21D1 | SNV | Missense_Mutation | novel | c.1300N>C | p.Ser434Pro | p.S434P | Q8N884 | protein_coding | deleterious(0.01) | possibly_damaging(0.473) | TCGA-CN-A63V-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MB21D1 | SNV | Missense_Mutation | c.1034N>T | p.Ser345Leu | p.S345L | Q8N884 | protein_coding | deleterious(0) | benign(0.392) | TCGA-CV-A45W-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MB21D1 | SNV | Missense_Mutation | novel | c.1303T>C | p.Ser435Pro | p.S435P | Q8N884 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B7-A5TN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
MB21D1 | SNV | Missense_Mutation | rs190867294 | c.1016N>A | p.Arg339His | p.R339H | Q8N884 | protein_coding | deleterious(0.01) | benign(0.229) | TCGA-BR-4257-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MB21D1 | SNV | Missense_Mutation | c.1130N>C | p.Leu377Pro | p.L377P | Q8N884 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MB21D1 | SNV | Missense_Mutation | rs370272118 | c.1147G>A | p.Glu383Lys | p.E383K | Q8N884 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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