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Gene: MAST3 |
Gene summary for MAST3 |
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Gene information | Species | Human | Gene symbol | MAST3 | Gene ID | 23031 |
Gene name | microtubule associated serine/threonine kinase 3 | |
Gene Alias | MAST3 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | O60307 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23031 | MAST3 | HCC1_Meng | Human | Liver | HCC | 3.46e-12 | -3.69e-03 | 0.0246 |
23031 | MAST3 | HCC1 | Human | Liver | HCC | 2.93e-04 | 3.09e+00 | 0.5336 |
23031 | MAST3 | HCC2 | Human | Liver | HCC | 1.39e-07 | 2.72e+00 | 0.5341 |
23031 | MAST3 | S014 | Human | Liver | HCC | 5.35e-12 | 4.94e-01 | 0.2254 |
23031 | MAST3 | S015 | Human | Liver | HCC | 9.45e-09 | 4.89e-01 | 0.2375 |
23031 | MAST3 | S016 | Human | Liver | HCC | 2.18e-13 | 4.85e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001810511 | Liver | HCC | peptidyl-serine phosphorylation | 169/7958 | 315/18723 | 3.86e-05 | 3.81e-04 | 169 |
GO:001820911 | Liver | HCC | peptidyl-serine modification | 177/7958 | 338/18723 | 1.45e-04 | 1.17e-03 | 177 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAST3 | SNV | Missense_Mutation | rs775231850 | c.2893N>T | p.Arg965Trp | p.R965W | O60307 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AG-3731-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | PR |
MAST3 | SNV | Missense_Mutation | novel | c.926N>C | p.Gly309Ala | p.G309A | O60307 | protein_coding | deleterious(0.04) | possibly_damaging(0.656) | TCGA-AG-3878-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MAST3 | SNV | Missense_Mutation | novel | c.1211N>C | p.Ile404Thr | p.I404T | O60307 | protein_coding | deleterious(0) | benign(0.06) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
MAST3 | deletion | Nonsense_Mutation | c.2273_2275delCTG | p.Ser758_Gly759delinsTer | p.S758_G759delins* | O60307 | protein_coding | TCGA-AA-3941-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
MAST3 | insertion | Frame_Shift_Ins | novel | c.200_201insA | p.Ala68CysfsTer73 | p.A68Cfs*73 | O60307 | protein_coding | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MAST3 | deletion | Frame_Shift_Del | c.1751delN | p.Glu586ArgfsTer49 | p.E586Rfs*49 | O60307 | protein_coding | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
MAST3 | SNV | Missense_Mutation | novel | c.1312N>G | p.Arg438Gly | p.R438G | O60307 | protein_coding | deleterious(0) | possibly_damaging(0.635) | TCGA-5S-A9Q8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
MAST3 | SNV | Missense_Mutation | novel | c.2339N>T | p.Thr780Ile | p.T780I | O60307 | protein_coding | tolerated_low_confidence(0.11) | benign(0.147) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAST3 | SNV | Missense_Mutation | novel | c.3803N>T | p.Ala1268Val | p.A1268V | O60307 | protein_coding | deleterious_low_confidence(0.02) | benign(0.3) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAST3 | SNV | Missense_Mutation | novel | c.1874G>A | p.Arg625His | p.R625H | O60307 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23031 | MAST3 | KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE, ENZYME | inhibitor | 252827499 |
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