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Gene: MAMSTR |
Gene summary for MAMSTR |
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Gene information | Species | Human | Gene symbol | MAMSTR | Gene ID | 284358 |
Gene name | MEF2 activating motif and SAP domain containing transcriptional regulator | |
Gene Alias | MASTR | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6ZN01 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284358 | MAMSTR | HCC1_Meng | Human | Liver | HCC | 6.25e-16 | 5.87e-02 | 0.0246 |
284358 | MAMSTR | S014 | Human | Liver | HCC | 1.30e-17 | 5.53e-01 | 0.2254 |
284358 | MAMSTR | S015 | Human | Liver | HCC | 8.51e-16 | 6.70e-01 | 0.2375 |
284358 | MAMSTR | S016 | Human | Liver | HCC | 3.12e-24 | 6.25e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAMSTR | SNV | Missense_Mutation | novel | c.536A>G | p.Glu179Gly | p.E179G | Q6ZN01 | protein_coding | deleterious(0) | possibly_damaging(0.857) | TCGA-85-8071-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MAMSTR | SNV | Missense_Mutation | novel | c.1178N>A | p.Ser393Asn | p.S393N | Q6ZN01 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-85-8479-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MAMSTR | SNV | Missense_Mutation | novel | c.1201G>C | p.Asp401His | p.D401H | Q6ZN01 | protein_coding | deleterious(0) | benign(0.215) | TCGA-BA-6868-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
MAMSTR | SNV | Missense_Mutation | novel | c.876G>C | p.Glu292Asp | p.E292D | Q6ZN01 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.987) | TCGA-KU-A66S-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
MAMSTR | SNV | Missense_Mutation | novel | c.802N>G | p.Pro268Ala | p.P268A | Q6ZN01 | protein_coding | tolerated(0.3) | benign(0.007) | TCGA-P3-A6T7-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
MAMSTR | SNV | Missense_Mutation | c.857C>T | p.Ser286Leu | p.S286L | Q6ZN01 | protein_coding | tolerated(0.06) | benign(0) | TCGA-KK-A6E8-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD | |
MAMSTR | deletion | Frame_Shift_Del | rs752869239 | c.485delC | p.Pro162HisfsTer14 | p.P162Hfs*14 | Q6ZN01 | protein_coding | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MAMSTR | insertion | Frame_Shift_Ins | rs765520198 | c.485dupC | p.His163ThrfsTer9 | p.H163Tfs*9 | Q6ZN01 | protein_coding | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MAMSTR | deletion | Frame_Shift_Del | rs752869239 | c.485delN | p.Pro162HisfsTer14 | p.P162Hfs*14 | Q6ZN01 | protein_coding | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD | ||
MAMSTR | deletion | Frame_Shift_Del | rs752869239 | c.485delN | p.Pro162HisfsTer14 | p.P162Hfs*14 | Q6ZN01 | protein_coding | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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