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Gene: MAGEA10 |
Gene summary for MAGEA10 |
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Gene information | Species | Human | Gene symbol | MAGEA10 | Gene ID | 4109 |
Gene name | MAGE family member A10 | |
Gene Alias | CT1.10 | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | B2RAE8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4109 | MAGEA10 | ATC09 | Human | Thyroid | ATC | 2.07e-20 | 6.90e-01 | 0.2871 |
4109 | MAGEA10 | ATC13 | Human | Thyroid | ATC | 1.51e-42 | 7.64e-01 | 0.34 |
4109 | MAGEA10 | ATC1 | Human | Thyroid | ATC | 6.34e-23 | 7.84e-01 | 0.2878 |
4109 | MAGEA10 | ATC5 | Human | Thyroid | ATC | 2.22e-48 | 8.46e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAGEA10 | SNV | Missense_Mutation | novel | c.392N>A | p.Arg131Lys | p.R131K | P43363 | protein_coding | tolerated(0.77) | benign(0.013) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAGEA10 | SNV | Missense_Mutation | novel | c.212C>A | p.Pro71Gln | p.P71Q | P43363 | protein_coding | tolerated(0.24) | benign(0.026) | TCGA-44-4112-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
MAGEA10 | SNV | Missense_Mutation | novel | c.798G>T | p.Glu266Asp | p.E266D | P43363 | protein_coding | tolerated(0.16) | benign(0.085) | TCGA-50-5941-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unspecific | Cisplatin | Complete Response |
MAGEA10 | SNV | Missense_Mutation | rs751437238 | c.289N>A | p.Val97Ile | p.V97I | P43363 | protein_coding | tolerated(1) | benign(0.003) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR |
MAGEA10 | SNV | Missense_Mutation | c.254N>T | p.Gln85Leu | p.Q85L | P43363 | protein_coding | deleterious(0.02) | probably_damaging(0.979) | TCGA-64-1679-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
MAGEA10 | SNV | Missense_Mutation | rs867080597 | c.913G>A | p.Glu305Lys | p.E305K | P43363 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-75-6214-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | PD |
MAGEA10 | SNV | Missense_Mutation | c.783N>G | p.His261Gln | p.H261Q | P43363 | protein_coding | tolerated(0.07) | possibly_damaging(0.892) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
MAGEA10 | SNV | Missense_Mutation | c.316N>C | p.Asp106His | p.D106H | P43363 | protein_coding | deleterious(0.05) | possibly_damaging(0.496) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MAGEA10 | SNV | Missense_Mutation | novel | c.580G>T | p.Val194Leu | p.V194L | P43363 | protein_coding | tolerated(0.1) | benign(0.04) | TCGA-99-7458-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | tarceva | SD |
MAGEA10 | SNV | Missense_Mutation | novel | c.1025N>T | p.Gln342Leu | p.Q342L | P43363 | protein_coding | deleterious(0) | benign(0.334) | TCGA-21-1076-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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