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Gene: MAF |
Gene summary for MAF |
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Gene information | Species | Human | Gene symbol | MAF | Gene ID | 4094 |
Gene name | MAF bZIP transcription factor | |
Gene Alias | AYGRP | |
Cytomap | 16q23.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O75444 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4094 | MAF | LZE4T | Human | Esophagus | ESCC | 6.27e-20 | 6.88e-01 | 0.0811 |
4094 | MAF | LZE20T | Human | Esophagus | ESCC | 4.14e-09 | 3.16e-01 | 0.0662 |
4094 | MAF | LZE24T | Human | Esophagus | ESCC | 1.70e-09 | 3.83e-01 | 0.0596 |
4094 | MAF | P1T-E | Human | Esophagus | ESCC | 4.23e-02 | 1.84e-01 | 0.0875 |
4094 | MAF | P2T-E | Human | Esophagus | ESCC | 1.34e-07 | 3.69e-02 | 0.1177 |
4094 | MAF | P4T-E | Human | Esophagus | ESCC | 8.80e-10 | 1.68e-01 | 0.1323 |
4094 | MAF | P5T-E | Human | Esophagus | ESCC | 3.27e-31 | 5.06e-01 | 0.1327 |
4094 | MAF | P8T-E | Human | Esophagus | ESCC | 6.55e-09 | 9.23e-02 | 0.0889 |
4094 | MAF | P9T-E | Human | Esophagus | ESCC | 6.99e-06 | 2.09e-01 | 0.1131 |
4094 | MAF | P10T-E | Human | Esophagus | ESCC | 9.13e-18 | 3.41e-01 | 0.116 |
4094 | MAF | P11T-E | Human | Esophagus | ESCC | 2.29e-09 | 5.97e-01 | 0.1426 |
4094 | MAF | P12T-E | Human | Esophagus | ESCC | 1.18e-15 | 2.40e-01 | 0.1122 |
4094 | MAF | P15T-E | Human | Esophagus | ESCC | 1.17e-03 | 2.07e-01 | 0.1149 |
4094 | MAF | P19T-E | Human | Esophagus | ESCC | 3.72e-02 | 2.16e-01 | 0.1662 |
4094 | MAF | P20T-E | Human | Esophagus | ESCC | 5.86e-08 | 2.28e-01 | 0.1124 |
4094 | MAF | P21T-E | Human | Esophagus | ESCC | 3.55e-13 | 1.94e-01 | 0.1617 |
4094 | MAF | P22T-E | Human | Esophagus | ESCC | 4.19e-47 | 8.28e-01 | 0.1236 |
4094 | MAF | P23T-E | Human | Esophagus | ESCC | 5.24e-06 | 2.14e-01 | 0.108 |
4094 | MAF | P24T-E | Human | Esophagus | ESCC | 3.30e-04 | 4.94e-02 | 0.1287 |
4094 | MAF | P26T-E | Human | Esophagus | ESCC | 3.18e-13 | 4.73e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00022629 | Breast | Precancer | myeloid cell homeostasis | 27/1080 | 157/18723 | 3.10e-07 | 1.49e-05 | 27 |
GO:00341019 | Breast | Precancer | erythrocyte homeostasis | 23/1080 | 129/18723 | 1.20e-06 | 4.60e-05 | 23 |
GO:00447063 | Breast | Precancer | multi-multicellular organism process | 31/1080 | 220/18723 | 3.73e-06 | 1.19e-04 | 31 |
GO:00300999 | Breast | Precancer | myeloid cell differentiation | 45/1080 | 381/18723 | 4.00e-06 | 1.25e-04 | 45 |
GO:00487329 | Breast | Precancer | gland development | 49/1080 | 436/18723 | 6.11e-06 | 1.73e-04 | 49 |
GO:00421107 | Breast | Precancer | T cell activation | 52/1080 | 487/18723 | 1.37e-05 | 3.42e-04 | 52 |
GO:00456379 | Breast | Precancer | regulation of myeloid cell differentiation | 28/1080 | 210/18723 | 3.05e-05 | 6.72e-04 | 28 |
GO:19037069 | Breast | Precancer | regulation of hemopoiesis | 41/1080 | 367/18723 | 3.95e-05 | 8.52e-04 | 41 |
GO:00025737 | Breast | Precancer | myeloid leukocyte differentiation | 27/1080 | 208/18723 | 6.72e-05 | 1.35e-03 | 27 |
GO:00488729 | Breast | Precancer | homeostasis of number of cells | 32/1080 | 272/18723 | 1.03e-04 | 1.89e-03 | 32 |
GO:19021055 | Breast | Precancer | regulation of leukocyte differentiation | 32/1080 | 279/18723 | 1.66e-04 | 2.74e-03 | 32 |
GO:00302189 | Breast | Precancer | erythrocyte differentiation | 18/1080 | 120/18723 | 1.76e-04 | 2.87e-03 | 18 |
GO:19031313 | Breast | Precancer | mononuclear cell differentiation | 43/1080 | 426/18723 | 2.61e-04 | 3.84e-03 | 43 |
GO:00085445 | Breast | Precancer | epidermis development | 35/1080 | 324/18723 | 2.71e-04 | 3.96e-03 | 35 |
GO:00027613 | Breast | Precancer | regulation of myeloid leukocyte differentiation | 17/1080 | 120/18723 | 5.23e-04 | 6.74e-03 | 17 |
GO:19021063 | Breast | Precancer | negative regulation of leukocyte differentiation | 15/1080 | 102/18723 | 7.34e-04 | 8.80e-03 | 15 |
GO:00454444 | Breast | Precancer | fat cell differentiation | 26/1080 | 229/18723 | 7.60e-04 | 9.04e-03 | 26 |
GO:0048538 | Breast | Precancer | thymus development | 9/1080 | 45/18723 | 9.22e-04 | 1.05e-02 | 9 |
GO:19037073 | Breast | Precancer | negative regulation of hemopoiesis | 15/1080 | 106/18723 | 1.10e-03 | 1.22e-02 | 15 |
GO:00456467 | Breast | Precancer | regulation of erythrocyte differentiation | 9/1080 | 47/18723 | 1.28e-03 | 1.36e-02 | 9 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa046585 | Esophagus | ESCC | Th1 and Th2 cell differentiation | 58/4205 | 92/8465 | 6.49e-03 | 1.60e-02 | 8.19e-03 | 58 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0465812 | Esophagus | ESCC | Th1 and Th2 cell differentiation | 58/4205 | 92/8465 | 6.49e-03 | 1.60e-02 | 8.19e-03 | 58 |
hsa046584 | Oral cavity | OSCC | Th1 and Th2 cell differentiation | 53/3704 | 92/8465 | 5.00e-03 | 1.20e-02 | 6.13e-03 | 53 |
hsa0465811 | Oral cavity | OSCC | Th1 and Th2 cell differentiation | 53/3704 | 92/8465 | 5.00e-03 | 1.20e-02 | 6.13e-03 | 53 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 2 3 4 5 6 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAF | SNV | Missense_Mutation | novel | c.941N>G | p.His314Arg | p.H314R | O75444 | protein_coding | tolerated(0.14) | probably_damaging(0.999) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
MAF | SNV | Missense_Mutation | novel | c.857N>C | p.Val286Ala | p.V286A | O75444 | protein_coding | tolerated(0.2) | probably_damaging(0.967) | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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