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Gene: LRRCC1 |
Gene summary for LRRCC1 |
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Gene information | Species | Human | Gene symbol | LRRCC1 | Gene ID | 85444 |
Gene name | leucine rich repeat and coiled-coil centrosomal protein 1 | |
Gene Alias | CLERC | |
Cytomap | 8q21.2 | |
Gene Type | protein-coding | GO ID | GO:0007049 | UniProtAcc | B4DTJ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85444 | LRRCC1 | LZE2T | Human | Esophagus | ESCC | 2.69e-05 | 6.31e-01 | 0.082 |
85444 | LRRCC1 | LZE24T | Human | Esophagus | ESCC | 4.45e-09 | 3.08e-01 | 0.0596 |
85444 | LRRCC1 | P2T-E | Human | Esophagus | ESCC | 2.68e-38 | 7.71e-01 | 0.1177 |
85444 | LRRCC1 | P4T-E | Human | Esophagus | ESCC | 1.05e-29 | 6.74e-01 | 0.1323 |
85444 | LRRCC1 | P5T-E | Human | Esophagus | ESCC | 9.80e-07 | 2.04e-01 | 0.1327 |
85444 | LRRCC1 | P8T-E | Human | Esophagus | ESCC | 2.26e-09 | 2.31e-01 | 0.0889 |
85444 | LRRCC1 | P9T-E | Human | Esophagus | ESCC | 2.15e-08 | 1.61e-01 | 0.1131 |
85444 | LRRCC1 | P10T-E | Human | Esophagus | ESCC | 2.16e-14 | 3.06e-01 | 0.116 |
85444 | LRRCC1 | P11T-E | Human | Esophagus | ESCC | 6.23e-15 | 5.97e-01 | 0.1426 |
85444 | LRRCC1 | P12T-E | Human | Esophagus | ESCC | 9.54e-18 | 3.75e-01 | 0.1122 |
85444 | LRRCC1 | P15T-E | Human | Esophagus | ESCC | 1.56e-05 | 1.87e-01 | 0.1149 |
85444 | LRRCC1 | P16T-E | Human | Esophagus | ESCC | 1.06e-25 | 5.68e-01 | 0.1153 |
85444 | LRRCC1 | P17T-E | Human | Esophagus | ESCC | 1.03e-07 | 3.08e-01 | 0.1278 |
85444 | LRRCC1 | P19T-E | Human | Esophagus | ESCC | 1.68e-08 | 5.24e-01 | 0.1662 |
85444 | LRRCC1 | P20T-E | Human | Esophagus | ESCC | 1.52e-06 | 1.50e-01 | 0.1124 |
85444 | LRRCC1 | P21T-E | Human | Esophagus | ESCC | 1.18e-16 | 3.73e-01 | 0.1617 |
85444 | LRRCC1 | P22T-E | Human | Esophagus | ESCC | 5.77e-09 | 2.16e-01 | 0.1236 |
85444 | LRRCC1 | P23T-E | Human | Esophagus | ESCC | 9.65e-11 | 2.69e-01 | 0.108 |
85444 | LRRCC1 | P24T-E | Human | Esophagus | ESCC | 3.02e-16 | 3.22e-01 | 0.1287 |
85444 | LRRCC1 | P26T-E | Human | Esophagus | ESCC | 2.72e-10 | 1.99e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRCC1 | SNV | Missense_Mutation | c.1009N>C | p.Tyr337His | p.Y337H | Q9C099 | protein_coding | tolerated(0.51) | benign(0.005) | TCGA-AG-3731-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | PR | |
LRRCC1 | SNV | Missense_Mutation | c.1019N>T | p.Arg340Ile | p.R340I | Q9C099 | protein_coding | tolerated(0.17) | possibly_damaging(0.503) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
LRRCC1 | SNV | Missense_Mutation | c.1991N>C | p.Val664Ala | p.V664A | Q9C099 | protein_coding | tolerated(0.1) | benign(0.031) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
LRRCC1 | SNV | Missense_Mutation | c.2864G>T | p.Ser955Ile | p.S955I | Q9C099 | protein_coding | tolerated(0.06) | benign(0.11) | TCGA-EI-6512-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folfox | SD | |
LRRCC1 | SNV | Missense_Mutation | rs750034546 | c.2350C>T | p.Arg784Cys | p.R784C | Q9C099 | protein_coding | deleterious(0.01) | benign(0.143) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
LRRCC1 | SNV | Missense_Mutation | c.349N>C | p.Ser117Pro | p.S117P | Q9C099 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
LRRCC1 | deletion | Frame_Shift_Del | novel | c.1501delN | p.Lys502AsnfsTer2 | p.K502Nfs*2 | Q9C099 | protein_coding | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
LRRCC1 | insertion | Frame_Shift_Ins | rs764658669 | c.1585_1586insA | p.Met531AsnfsTer28 | p.M531Nfs*28 | Q9C099 | protein_coding | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
LRRCC1 | insertion | Frame_Shift_Ins | novel | c.2633_2634insA | p.Glu880ArgfsTer15 | p.E880Rfs*15 | Q9C099 | protein_coding | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | ||
LRRCC1 | insertion | Frame_Shift_Ins | novel | c.2095_2096insA | p.Thr701AsnfsTer8 | p.T701Nfs*8 | Q9C099 | protein_coding | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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