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Gene: LRRC8B |
Gene summary for LRRC8B |
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Gene information | Species | Human | Gene symbol | LRRC8B | Gene ID | 23507 |
Gene name | leucine rich repeat containing 8 VRAC subunit B | |
Gene Alias | TA-LRRP | |
Cytomap | 1p22.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q6P9F7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23507 | LRRC8B | LZE4T | Human | Esophagus | ESCC | 1.06e-04 | 9.98e-02 | 0.0811 |
23507 | LRRC8B | LZE22T | Human | Esophagus | ESCC | 2.26e-02 | 1.50e-01 | 0.068 |
23507 | LRRC8B | LZE24T | Human | Esophagus | ESCC | 3.69e-05 | 1.33e-01 | 0.0596 |
23507 | LRRC8B | P2T-E | Human | Esophagus | ESCC | 8.02e-12 | 1.62e-01 | 0.1177 |
23507 | LRRC8B | P4T-E | Human | Esophagus | ESCC | 5.49e-09 | 1.37e-01 | 0.1323 |
23507 | LRRC8B | P5T-E | Human | Esophagus | ESCC | 1.47e-06 | 1.31e-01 | 0.1327 |
23507 | LRRC8B | P8T-E | Human | Esophagus | ESCC | 1.48e-05 | 6.48e-02 | 0.0889 |
23507 | LRRC8B | P9T-E | Human | Esophagus | ESCC | 4.29e-03 | 1.23e-01 | 0.1131 |
23507 | LRRC8B | P10T-E | Human | Esophagus | ESCC | 7.40e-06 | 9.31e-02 | 0.116 |
23507 | LRRC8B | P11T-E | Human | Esophagus | ESCC | 6.57e-03 | 7.42e-02 | 0.1426 |
23507 | LRRC8B | P12T-E | Human | Esophagus | ESCC | 1.02e-65 | 1.29e+00 | 0.1122 |
23507 | LRRC8B | P15T-E | Human | Esophagus | ESCC | 1.63e-11 | 2.22e-01 | 0.1149 |
23507 | LRRC8B | P16T-E | Human | Esophagus | ESCC | 2.83e-05 | 1.35e-02 | 0.1153 |
23507 | LRRC8B | P20T-E | Human | Esophagus | ESCC | 1.71e-07 | 1.30e-01 | 0.1124 |
23507 | LRRC8B | P22T-E | Human | Esophagus | ESCC | 1.97e-02 | -1.84e-02 | 0.1236 |
23507 | LRRC8B | P23T-E | Human | Esophagus | ESCC | 1.54e-15 | 2.83e-01 | 0.108 |
23507 | LRRC8B | P24T-E | Human | Esophagus | ESCC | 1.62e-04 | 1.95e-02 | 0.1287 |
23507 | LRRC8B | P26T-E | Human | Esophagus | ESCC | 5.87e-12 | 3.10e-01 | 0.1276 |
23507 | LRRC8B | P27T-E | Human | Esophagus | ESCC | 2.82e-06 | 1.13e-01 | 0.1055 |
23507 | LRRC8B | P28T-E | Human | Esophagus | ESCC | 3.15e-11 | 1.87e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRC8B | SNV | Missense_Mutation | novel | c.1709N>G | p.Asn570Ser | p.N570S | protein_coding | deleterious(0.04) | probably_damaging(0.968) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LRRC8B | SNV | Missense_Mutation | rs756518618 | c.386C>T | p.Thr129Met | p.T129M | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-B5-A3FD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
LRRC8B | SNV | Missense_Mutation | c.169N>A | p.Pro57Thr | p.P57T | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LRRC8B | SNV | Missense_Mutation | rs760640193 | c.218N>C | p.Leu73Pro | p.L73P | protein_coding | tolerated(0.23) | benign(0.188) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
LRRC8B | SNV | Missense_Mutation | novel | c.994T>C | p.Tyr332His | p.Y332H | protein_coding | deleterious(0.01) | benign(0.012) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
LRRC8B | SNV | Missense_Mutation | rs755825664 | c.275N>A | p.Arg92Gln | p.R92Q | protein_coding | tolerated(0.18) | benign(0.04) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
LRRC8B | SNV | Missense_Mutation | novel | c.1936N>A | p.Ala646Thr | p.A646T | protein_coding | tolerated(0.62) | benign(0.055) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
LRRC8B | SNV | Missense_Mutation | c.1604N>G | p.Gln535Arg | p.Q535R | protein_coding | tolerated(1) | benign(0.01) | TCGA-DI-A0WH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
LRRC8B | SNV | Missense_Mutation | novel | c.481N>A | p.Asp161Asn | p.D161N | protein_coding | deleterious(0) | possibly_damaging(0.849) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LRRC8B | SNV | Missense_Mutation | rs375681290 | c.901N>T | p.Arg301Cys | p.R301C | protein_coding | tolerated(0.18) | benign(0.265) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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