![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: LIN37 |
Gene summary for LIN37 |
![]() |
Gene information | Species | Human | Gene symbol | LIN37 | Gene ID | 55957 |
Gene name | lin-37 DREAM MuvB core complex component | |
Gene Alias | F25965 | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q96GY3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55957 | LIN37 | LZE4T | Human | Esophagus | ESCC | 1.70e-03 | 1.29e-01 | 0.0811 |
55957 | LIN37 | LZE20T | Human | Esophagus | ESCC | 1.26e-02 | 1.17e-01 | 0.0662 |
55957 | LIN37 | LZE24T | Human | Esophagus | ESCC | 6.88e-12 | 2.63e-01 | 0.0596 |
55957 | LIN37 | LZE21T | Human | Esophagus | ESCC | 6.52e-03 | 2.04e-01 | 0.0655 |
55957 | LIN37 | P1T-E | Human | Esophagus | ESCC | 5.20e-08 | 2.75e-01 | 0.0875 |
55957 | LIN37 | P2T-E | Human | Esophagus | ESCC | 3.07e-06 | 1.76e-01 | 0.1177 |
55957 | LIN37 | P4T-E | Human | Esophagus | ESCC | 2.81e-07 | 1.81e-01 | 0.1323 |
55957 | LIN37 | P5T-E | Human | Esophagus | ESCC | 1.50e-14 | 2.44e-01 | 0.1327 |
55957 | LIN37 | P8T-E | Human | Esophagus | ESCC | 1.22e-26 | 4.41e-01 | 0.0889 |
55957 | LIN37 | P9T-E | Human | Esophagus | ESCC | 1.23e-14 | 3.18e-01 | 0.1131 |
55957 | LIN37 | P10T-E | Human | Esophagus | ESCC | 3.39e-31 | 4.89e-01 | 0.116 |
55957 | LIN37 | P11T-E | Human | Esophagus | ESCC | 3.75e-08 | 2.64e-01 | 0.1426 |
55957 | LIN37 | P12T-E | Human | Esophagus | ESCC | 6.60e-11 | 2.04e-01 | 0.1122 |
55957 | LIN37 | P15T-E | Human | Esophagus | ESCC | 5.37e-05 | 1.26e-01 | 0.1149 |
55957 | LIN37 | P16T-E | Human | Esophagus | ESCC | 1.02e-08 | 1.77e-01 | 0.1153 |
55957 | LIN37 | P17T-E | Human | Esophagus | ESCC | 1.49e-05 | 2.36e-01 | 0.1278 |
55957 | LIN37 | P20T-E | Human | Esophagus | ESCC | 1.73e-12 | 2.60e-01 | 0.1124 |
55957 | LIN37 | P21T-E | Human | Esophagus | ESCC | 2.66e-06 | 1.31e-01 | 0.1617 |
55957 | LIN37 | P22T-E | Human | Esophagus | ESCC | 5.47e-10 | 2.31e-01 | 0.1236 |
55957 | LIN37 | P23T-E | Human | Esophagus | ESCC | 9.64e-32 | 5.46e-01 | 0.108 |
Page: 1 2 3 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0421829 | Esophagus | ESCC | Cellular senescence | 119/4205 | 156/8465 | 5.89e-12 | 9.40e-11 | 4.81e-11 | 119 |
hsa0421838 | Esophagus | ESCC | Cellular senescence | 119/4205 | 156/8465 | 5.89e-12 | 9.40e-11 | 4.81e-11 | 119 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LIN37 | SNV | Missense_Mutation | novel | c.547N>T | p.Pro183Ser | p.P183S | Q96GY3 | protein_coding | tolerated(0.14) | benign(0.235) | TCGA-CR-6473-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | paclitaxel | SD |
LIN37 | SNV | Missense_Mutation | c.138A>C | p.Lys46Asn | p.K46N | Q96GY3 | protein_coding | tolerated(0.05) | probably_damaging(0.947) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
LIN37 | SNV | Missense_Mutation | rs752115972 | c.536G>A | p.Arg179His | p.R179H | Q96GY3 | protein_coding | tolerated(0.06) | probably_damaging(0.996) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
LIN37 | SNV | Missense_Mutation | c.731A>G | p.Glu244Gly | p.E244G | Q96GY3 | protein_coding | deleterious(0) | benign(0.136) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |