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Gene: LGALS4 |
Gene summary for LGALS4 |
Gene summary. |
Gene information | Species | Human | Gene symbol | LGALS4 | Gene ID | 3960 |
Gene name | galectin 4 | |
Gene Alias | GAL4 | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | P56470 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3960 | LGALS4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.06e-32 | 1.06e+00 | 0.0155 |
3960 | LGALS4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.67e-48 | 3.32e+00 | -0.1808 |
3960 | LGALS4 | HTA11_2951_2000001011 | Human | Colorectum | AD | 5.19e-17 | 1.36e+00 | 0.0216 |
3960 | LGALS4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.64e-40 | 2.59e+00 | -0.0811 |
3960 | LGALS4 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.77e-33 | 2.30e+00 | -0.1088 |
3960 | LGALS4 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.65e-76 | 3.38e+00 | -0.1954 |
3960 | LGALS4 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.30e-31 | 3.82e+00 | -0.2602 |
3960 | LGALS4 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.79e-24 | 3.98e+00 | -0.2196 |
3960 | LGALS4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.33e-46 | 3.31e+00 | -0.1207 |
3960 | LGALS4 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.01e-48 | 3.54e+00 | -0.1526 |
3960 | LGALS4 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.24e-54 | 3.34e+00 | -0.1464 |
3960 | LGALS4 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.36e-54 | 2.49e+00 | -0.1001 |
3960 | LGALS4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.34e-45 | 3.21e+00 | -0.059 |
3960 | LGALS4 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.25e-35 | 3.73e+00 | -0.1706 |
3960 | LGALS4 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.26e-45 | 3.47e+00 | -0.2061 |
3960 | LGALS4 | HTA11_5216_2000001011 | Human | Colorectum | SER | 8.44e-32 | 3.43e+00 | -0.1462 |
3960 | LGALS4 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.94e-35 | 2.63e+00 | -0.0842 |
3960 | LGALS4 | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.23e-41 | 2.42e+00 | -0.00410000000000005 |
3960 | LGALS4 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.12e-44 | 2.45e+00 | -0.0179 |
3960 | LGALS4 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.01e-22 | 1.53e+00 | 0.096 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LGALS4 | SNV | Missense_Mutation | c.564N>G | p.Phe188Leu | p.F188L | P56470 | protein_coding | tolerated(0.2) | benign(0.001) | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR | |
LGALS4 | SNV | Missense_Mutation | rs199814280 | c.905N>T | p.Ser302Leu | p.S302L | P56470 | protein_coding | tolerated(0.25) | benign(0.003) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
LGALS4 | SNV | Missense_Mutation | c.724N>A | p.Gly242Ser | p.G242S | P56470 | protein_coding | tolerated(0.91) | benign(0.003) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
LGALS4 | SNV | Missense_Mutation | novel | c.718N>A | p.Arg240Ser | p.R240S | P56470 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-60-2720-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
LGALS4 | deletion | Frame_Shift_Del | c.209delN | p.Gly70AlafsTer37 | p.G70Afs*37 | P56470 | protein_coding | TCGA-97-7937-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
LGALS4 | deletion | Frame_Shift_Del | novel | c.74_78delNNNNN | p.Gly25AlafsTer43 | p.G25Afs*43 | P56470 | protein_coding | TCGA-77-6845-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
LGALS4 | SNV | Missense_Mutation | rs537002104 | c.233N>T | p.Thr78Met | p.T78M | P56470 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CQ-5327-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
LGALS4 | SNV | Missense_Mutation | novel | c.775G>A | p.Glu259Lys | p.E259K | P56470 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CV-7422-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
LGALS4 | SNV | Missense_Mutation | rs371360675 | c.719G>A | p.Arg240His | p.R240H | P56470 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LGALS4 | SNV | Missense_Mutation | c.80N>C | p.Leu27Pro | p.L27P | P56470 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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