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Gene: LENG9 |
Gene summary for LENG9 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | LENG9 | Gene ID | 94059 |
| Gene name | leukocyte receptor cluster member 9 | |
| Gene Alias | LENG9 | |
| Cytomap | 19q13.42 | |
| Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A087WVD1 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 94059 | LENG9 | LZE24T | Human | Esophagus | ESCC | 1.44e-13 | 3.89e-01 | 0.0596 |
| 94059 | LENG9 | LZE21T | Human | Esophagus | ESCC | 9.27e-04 | 2.40e-01 | 0.0655 |
| 94059 | LENG9 | P1T-E | Human | Esophagus | ESCC | 8.82e-20 | 9.07e-01 | 0.0875 |
| 94059 | LENG9 | P2T-E | Human | Esophagus | ESCC | 1.99e-07 | 1.46e-01 | 0.1177 |
| 94059 | LENG9 | P4T-E | Human | Esophagus | ESCC | 7.68e-05 | 8.76e-02 | 0.1323 |
| 94059 | LENG9 | P8T-E | Human | Esophagus | ESCC | 1.94e-15 | 2.77e-01 | 0.0889 |
| 94059 | LENG9 | P15T-E | Human | Esophagus | ESCC | 3.98e-05 | 1.09e-01 | 0.1149 |
| 94059 | LENG9 | P20T-E | Human | Esophagus | ESCC | 1.25e-03 | 1.26e-01 | 0.1124 |
| 94059 | LENG9 | P21T-E | Human | Esophagus | ESCC | 1.08e-05 | 1.25e-01 | 0.1617 |
| 94059 | LENG9 | P23T-E | Human | Esophagus | ESCC | 1.09e-13 | 3.49e-01 | 0.108 |
| 94059 | LENG9 | P24T-E | Human | Esophagus | ESCC | 5.06e-12 | 1.55e-01 | 0.1287 |
| 94059 | LENG9 | P26T-E | Human | Esophagus | ESCC | 2.85e-10 | 1.51e-01 | 0.1276 |
| 94059 | LENG9 | P28T-E | Human | Esophagus | ESCC | 2.06e-09 | 1.06e-01 | 0.1149 |
| 94059 | LENG9 | P31T-E | Human | Esophagus | ESCC | 1.37e-03 | 1.56e-01 | 0.1251 |
| 94059 | LENG9 | P32T-E | Human | Esophagus | ESCC | 5.74e-06 | 7.73e-02 | 0.1666 |
| 94059 | LENG9 | P36T-E | Human | Esophagus | ESCC | 1.09e-09 | 2.97e-01 | 0.1187 |
| 94059 | LENG9 | P37T-E | Human | Esophagus | ESCC | 2.21e-07 | 1.65e-01 | 0.1371 |
| 94059 | LENG9 | P39T-E | Human | Esophagus | ESCC | 2.18e-06 | 1.08e-01 | 0.0894 |
| 94059 | LENG9 | P42T-E | Human | Esophagus | ESCC | 4.69e-06 | 2.36e-01 | 0.1175 |
| 94059 | LENG9 | P44T-E | Human | Esophagus | ESCC | 1.73e-02 | 1.07e-01 | 0.1096 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| LENG9 | SNV | Missense_Mutation | novel | c.854N>T | p.Ala285Val | p.A285V | protein_coding | tolerated(0.2) | benign(0.077) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| LENG9 | SNV | Missense_Mutation | novel | c.1324N>C | p.Glu442Gln | p.E442Q | protein_coding | tolerated(0.4) | possibly_damaging(0.801) | TCGA-MT-A67D-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| LENG9 | SNV | Missense_Mutation | novel | c.1336N>T | p.Ser446Cys | p.S446C | protein_coding | tolerated(0.06) | possibly_damaging(0.84) | TCGA-BR-8297-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | SD | |
| LENG9 | SNV | Missense_Mutation | novel | c.455N>T | p.Ala152Val | p.A152V | protein_coding | deleterious(0.01) | benign(0.232) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| LENG9 | SNV | Missense_Mutation | novel | c.567G>C | p.Lys189Asn | p.K189N | protein_coding | tolerated(0.46) | benign(0.007) | TCGA-HU-8604-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | doxifluridine | SD | |
| LENG9 | deletion | Frame_Shift_Del | novel | c.761delN | p.Gly254AlafsTer52 | p.G254Afs*52 | protein_coding | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
| Page: 1 2 3 4 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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