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Gene: LAMP1 |
Gene summary for LAMP1 |
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Gene information | Species | Human | Gene symbol | LAMP1 | Gene ID | 3916 |
Gene name | lysosomal associated membrane protein 1 | |
Gene Alias | CD107a | |
Cytomap | 13q34 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | A0A024RDY3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3916 | LAMP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.61e-08 | 3.28e-01 | 0.0155 |
3916 | LAMP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.36e-16 | 8.99e-01 | -0.1808 |
3916 | LAMP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.90e-25 | 1.08e+00 | -0.0811 |
3916 | LAMP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.97e-14 | 7.22e-01 | -0.1088 |
3916 | LAMP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.61e-40 | 1.02e+00 | -0.1954 |
3916 | LAMP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.83e-11 | 1.57e+00 | -0.2602 |
3916 | LAMP1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.60e-09 | 1.14e+00 | -0.2196 |
3916 | LAMP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.14e-04 | 5.64e-01 | -0.1207 |
3916 | LAMP1 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.84e-16 | 1.02e+00 | -0.1526 |
3916 | LAMP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.35e-41 | 1.03e+00 | -0.1464 |
3916 | LAMP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.18e-18 | 5.52e-01 | -0.1001 |
3916 | LAMP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.08e-24 | 1.15e+00 | -0.059 |
3916 | LAMP1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.22e-09 | 1.09e+00 | -0.1706 |
3916 | LAMP1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.73e-17 | 1.38e+00 | -0.2061 |
3916 | LAMP1 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.52e-06 | 5.69e-01 | -0.0842 |
3916 | LAMP1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.11e-10 | 7.90e-01 | -0.0179 |
3916 | LAMP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.89e-24 | 9.08e-01 | 0.096 |
3916 | LAMP1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 6.61e-03 | 6.99e-01 | 0.0446 |
3916 | LAMP1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.72e-07 | 7.32e-01 | 0.0528 |
3916 | LAMP1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.50e-07 | 9.32e-01 | 0.0131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0019058 | Colorectum | AD | viral life cycle | 119/3918 | 317/18723 | 6.18e-12 | 8.23e-10 | 119 |
GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0031647 | Colorectum | AD | regulation of protein stability | 108/3918 | 298/18723 | 6.33e-10 | 5.08e-08 | 108 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0016482 | Colorectum | AD | cytosolic transport | 68/3918 | 168/18723 | 6.00e-09 | 3.72e-07 | 68 |
GO:0050821 | Colorectum | AD | protein stabilization | 73/3918 | 191/18723 | 3.02e-08 | 1.64e-06 | 73 |
GO:0044403 | Colorectum | AD | biological process involved in symbiotic interaction | 99/3918 | 290/18723 | 1.02e-07 | 4.93e-06 | 99 |
GO:0006892 | Colorectum | AD | post-Golgi vesicle-mediated transport | 45/3918 | 104/18723 | 2.22e-07 | 9.26e-06 | 45 |
GO:0007034 | Colorectum | AD | vacuolar transport | 60/3918 | 157/18723 | 4.97e-07 | 1.85e-05 | 60 |
GO:0051701 | Colorectum | AD | biological process involved in interaction with host | 73/3918 | 203/18723 | 5.08e-07 | 1.88e-05 | 73 |
GO:0032386 | Colorectum | AD | regulation of intracellular transport | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0052126 | Colorectum | AD | movement in host environment | 63/3918 | 175/18723 | 2.85e-06 | 8.11e-05 | 63 |
GO:0046718 | Colorectum | AD | viral entry into host cell | 51/3918 | 144/18723 | 3.99e-05 | 7.16e-04 | 51 |
GO:0007041 | Colorectum | AD | lysosomal transport | 42/3918 | 114/18723 | 6.61e-05 | 1.07e-03 | 42 |
GO:0045921 | Colorectum | AD | positive regulation of exocytosis | 33/3918 | 86/18723 | 1.58e-04 | 2.20e-03 | 33 |
GO:0044409 | Colorectum | AD | entry into host | 51/3918 | 151/18723 | 1.60e-04 | 2.21e-03 | 51 |
GO:0051047 | Colorectum | AD | positive regulation of secretion | 90/3918 | 310/18723 | 4.11e-04 | 4.66e-03 | 90 |
GO:1903532 | Colorectum | AD | positive regulation of secretion by cell | 82/3918 | 282/18723 | 6.85e-04 | 7.00e-03 | 82 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04140 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa041401 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa04142 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa041402 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041421 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa041403 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041404 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa041405 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa04145 | Colorectum | MSI-H | Phagosome | 27/797 | 152/8465 | 8.74e-04 | 1.01e-02 | 8.48e-03 | 27 |
hsa041451 | Colorectum | MSI-H | Phagosome | 27/797 | 152/8465 | 8.74e-04 | 1.01e-02 | 8.48e-03 | 27 |
hsa0414524 | Endometrium | AEH | Phagosome | 41/1197 | 152/8465 | 2.12e-05 | 2.22e-04 | 1.63e-04 | 41 |
hsa04145111 | Endometrium | AEH | Phagosome | 41/1197 | 152/8465 | 2.12e-05 | 2.22e-04 | 1.63e-04 | 41 |
hsa0414525 | Endometrium | EEC | Phagosome | 42/1237 | 152/8465 | 2.01e-05 | 2.28e-04 | 1.70e-04 | 42 |
hsa0414534 | Endometrium | EEC | Phagosome | 42/1237 | 152/8465 | 2.01e-05 | 2.28e-04 | 1.70e-04 | 42 |
hsa041426 | Esophagus | HGIN | Lysosome | 33/1383 | 132/8465 | 6.65e-03 | 4.37e-02 | 3.47e-02 | 33 |
hsa0414213 | Esophagus | HGIN | Lysosome | 33/1383 | 132/8465 | 6.65e-03 | 4.37e-02 | 3.47e-02 | 33 |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0414010 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa0414530 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
hsa051527 | Esophagus | ESCC | Tuberculosis | 111/4205 | 180/8465 | 7.14e-04 | 2.32e-03 | 1.19e-03 | 111 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LAMP1 | SNV | Missense_Mutation | novel | c.1052N>T | p.Ser351Leu | p.S351L | P11279 | protein_coding | tolerated(0.52) | benign(0.124) | TCGA-P3-A6T3-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
LAMP1 | SNV | Missense_Mutation | novel | c.1119N>T | p.Glu373Asp | p.E373D | P11279 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
LAMP1 | SNV | Missense_Mutation | rs767683537 | c.1033C>T | p.Arg345Cys | p.R345C | P11279 | protein_coding | tolerated(0.17) | possibly_damaging(0.759) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LAMP1 | SNV | Missense_Mutation | rs865825882 | c.130N>A | p.Ala44Thr | p.A44T | P11279 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-HU-A4H3-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | ts-1 | PD |
LAMP1 | SNV | Missense_Mutation | novel | c.508N>A | p.Leu170Ile | p.L170I | P11279 | protein_coding | deleterious(0.04) | possibly_damaging(0.446) | TCGA-VQ-AA6B-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3916 | LAMP1 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | DIMETHYL SULFOXIDE | 2243101 |
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