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Gene: KRT80 |
Gene summary for KRT80 |
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Gene information | Species | Human | Gene symbol | KRT80 | Gene ID | 144501 |
Gene name | keratin 80 | |
Gene Alias | KB20 | |
Cytomap | 12q13.13 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6KB66 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
144501 | KRT80 | LZE24T | Human | Esophagus | ESCC | 9.85e-13 | 9.59e-01 | 0.0596 |
144501 | KRT80 | P1T-E | Human | Esophagus | ESCC | 2.42e-02 | 5.77e-01 | 0.0875 |
144501 | KRT80 | P4T-E | Human | Esophagus | ESCC | 1.25e-03 | 2.97e-02 | 0.1323 |
144501 | KRT80 | P5T-E | Human | Esophagus | ESCC | 8.82e-03 | 1.57e-01 | 0.1327 |
144501 | KRT80 | P8T-E | Human | Esophagus | ESCC | 6.93e-12 | 2.14e-01 | 0.0889 |
144501 | KRT80 | P17T-E | Human | Esophagus | ESCC | 3.46e-05 | 3.22e-01 | 0.1278 |
144501 | KRT80 | P23T-E | Human | Esophagus | ESCC | 5.53e-12 | 1.55e+00 | 0.108 |
144501 | KRT80 | P31T-E | Human | Esophagus | ESCC | 2.42e-04 | 3.54e-01 | 0.1251 |
144501 | KRT80 | P36T-E | Human | Esophagus | ESCC | 1.27e-02 | 6.65e-01 | 0.1187 |
144501 | KRT80 | P37T-E | Human | Esophagus | ESCC | 5.57e-03 | 1.19e-01 | 0.1371 |
144501 | KRT80 | P39T-E | Human | Esophagus | ESCC | 9.64e-16 | 1.08e+00 | 0.0894 |
144501 | KRT80 | P57T-E | Human | Esophagus | ESCC | 6.34e-08 | 3.86e-01 | 0.0926 |
144501 | KRT80 | P61T-E | Human | Esophagus | ESCC | 4.68e-08 | 3.17e-01 | 0.099 |
144501 | KRT80 | P75T-E | Human | Esophagus | ESCC | 3.07e-19 | 7.83e-01 | 0.1125 |
144501 | KRT80 | P76T-E | Human | Esophagus | ESCC | 9.49e-11 | 4.46e-01 | 0.1207 |
144501 | KRT80 | P79T-E | Human | Esophagus | ESCC | 1.49e-03 | 1.30e-01 | 0.1154 |
144501 | KRT80 | P82T-E | Human | Esophagus | ESCC | 9.73e-09 | 1.43e+00 | 0.1072 |
144501 | KRT80 | P107T-E | Human | Esophagus | ESCC | 1.48e-20 | 7.08e-01 | 0.171 |
144501 | KRT80 | P128T-E | Human | Esophagus | ESCC | 2.30e-09 | 5.12e-01 | 0.1241 |
144501 | KRT80 | P130T-E | Human | Esophagus | ESCC | 3.71e-38 | 8.51e-01 | 0.1676 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KRT80 | SNV | Missense_Mutation | rs200315755 | c.704N>T | p.Ser235Leu | p.S235L | Q6KB66 | protein_coding | deleterious(0) | probably_damaging(0.937) | TCGA-IQ-A6SH-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
KRT80 | insertion | Frame_Shift_Ins | novel | c.829_830insC | p.Gln277ProfsTer55 | p.Q277Pfs*55 | Q6KB66 | protein_coding | TCGA-UF-A719-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
KRT80 | SNV | Missense_Mutation | rs565212849 | c.788C>T | p.Ala263Val | p.A263V | Q6KB66 | protein_coding | deleterious(0.04) | benign(0.216) | TCGA-J9-A52C-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
KRT80 | SNV | Missense_Mutation | rs766339844 | c.511T>C | p.Tyr171His | p.Y171H | Q6KB66 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-J9-A52C-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
KRT80 | SNV | Missense_Mutation | c.1268C>T | p.Ser423Phe | p.S423F | Q6KB66 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
KRT80 | SNV | Missense_Mutation | rs141107117 | c.887G>A | p.Arg296His | p.R296H | Q6KB66 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
KRT80 | SNV | Missense_Mutation | rs759253762 | c.754G>A | p.Val252Met | p.V252M | Q6KB66 | protein_coding | deleterious(0.02) | benign(0.283) | TCGA-L6-A4ET-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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