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Gene: KLK6 |
Gene summary for KLK6 |
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Gene information | Species | Human | Gene symbol | KLK6 | Gene ID | 5653 |
Gene name | kallikrein related peptidase 6 | |
Gene Alias | Bssp | |
Cytomap | 19q13.41 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | A0A024R4J8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5653 | KLK6 | LZE22T | Human | Esophagus | ESCC | 1.18e-02 | 8.82e-01 | 0.068 |
5653 | KLK6 | P2T-E | Human | Esophagus | ESCC | 1.15e-02 | 1.51e-01 | 0.1177 |
5653 | KLK6 | P15T-E | Human | Esophagus | ESCC | 1.19e-23 | 6.39e-01 | 0.1149 |
5653 | KLK6 | P16T-E | Human | Esophagus | ESCC | 1.79e-70 | 1.65e+00 | 0.1153 |
5653 | KLK6 | P21T-E | Human | Esophagus | ESCC | 3.50e-02 | 1.10e-01 | 0.1617 |
5653 | KLK6 | P22T-E | Human | Esophagus | ESCC | 2.86e-20 | 4.61e-01 | 0.1236 |
5653 | KLK6 | P31T-E | Human | Esophagus | ESCC | 4.40e-09 | 5.17e-01 | 0.1251 |
5653 | KLK6 | P37T-E | Human | Esophagus | ESCC | 3.70e-03 | 1.59e-01 | 0.1371 |
5653 | KLK6 | P47T-E | Human | Esophagus | ESCC | 3.89e-12 | 5.70e-01 | 0.1067 |
5653 | KLK6 | P49T-E | Human | Esophagus | ESCC | 1.61e-16 | 1.35e+00 | 0.1768 |
5653 | KLK6 | P56T-E | Human | Esophagus | ESCC | 6.85e-08 | 1.30e+00 | 0.1613 |
5653 | KLK6 | P61T-E | Human | Esophagus | ESCC | 1.62e-06 | 2.44e-01 | 0.099 |
5653 | KLK6 | P74T-E | Human | Esophagus | ESCC | 1.73e-25 | 8.22e-01 | 0.1479 |
5653 | KLK6 | P76T-E | Human | Esophagus | ESCC | 1.42e-30 | 8.30e-01 | 0.1207 |
5653 | KLK6 | P82T-E | Human | Esophagus | ESCC | 8.16e-03 | 1.11e+00 | 0.1072 |
5653 | KLK6 | P126T-E | Human | Esophagus | ESCC | 5.74e-05 | 4.96e-01 | 0.1125 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:003109910 | Esophagus | ESCC | regeneration | 122/8552 | 198/18723 | 4.26e-06 | 4.57e-05 | 122 |
GO:001648514 | Esophagus | ESCC | protein processing | 134/8552 | 225/18723 | 1.81e-05 | 1.60e-04 | 134 |
GO:00425524 | Esophagus | ESCC | myelination | 85/8552 | 134/18723 | 2.51e-05 | 2.13e-04 | 85 |
GO:00072724 | Esophagus | ESCC | ensheathment of neurons | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00083664 | Esophagus | ESCC | axon ensheathment | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:001097516 | Esophagus | ESCC | regulation of neuron projection development | 240/8552 | 445/18723 | 2.48e-04 | 1.53e-03 | 240 |
GO:00329631 | Esophagus | ESCC | collagen metabolic process | 62/8552 | 104/18723 | 2.90e-03 | 1.22e-02 | 62 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLK6 | SNV | Missense_Mutation | c.101C>A | p.Pro34His | p.P34H | Q92876 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
KLK6 | SNV | Missense_Mutation | c.182N>G | p.Ala61Gly | p.A61G | Q92876 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-18-3416-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KLK6 | SNV | Missense_Mutation | novel | c.230T>A | p.Leu77His | p.L77H | Q92876 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-37-3792-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KLK6 | SNV | Missense_Mutation | novel | c.650N>A | p.Pro217His | p.P217H | Q92876 | protein_coding | tolerated(0.05) | probably_damaging(0.972) | TCGA-66-2789-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
KLK6 | SNV | Missense_Mutation | novel | c.711C>G | p.Ile237Met | p.I237M | Q92876 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-68-A59J-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KLK6 | SNV | Missense_Mutation | novel | c.422N>A | p.Leu141Gln | p.L141Q | Q92876 | protein_coding | deleterious(0.03) | probably_damaging(0.972) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KLK6 | deletion | Frame_Shift_Del | novel | c.513delC | p.Tyr172ThrfsTer78 | p.Y172Tfs*78 | Q92876 | protein_coding | TCGA-55-7907-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
KLK6 | SNV | Missense_Mutation | rs777841287 | c.599N>T | p.Pro200Leu | p.P200L | Q92876 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-HC-7742-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Hormone Therapy | eligard | PR |
KLK6 | SNV | Missense_Mutation | c.541N>G | p.Leu181Val | p.L181V | Q92876 | protein_coding | tolerated(1) | benign(0.003) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KLK6 | SNV | Missense_Mutation | rs768388862 | c.494G>A | p.Arg165His | p.R165H | Q92876 | protein_coding | tolerated(0.35) | benign(0.005) | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5653 | KLK6 | PROTEASE, ENZYME, DRUGGABLE GENOME | inhibitor | 404859022 | ||
5653 | KLK6 | PROTEASE, ENZYME, DRUGGABLE GENOME | inhibitor | 404859023 | ||
5653 | KLK6 | PROTEASE, ENZYME, DRUGGABLE GENOME | inhibitor | 252166855 |
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