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Gene: KLK5 |
Gene summary for KLK5 |
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Gene information | Species | Human | Gene symbol | KLK5 | Gene ID | 25818 |
Gene name | kallikrein related peptidase 5 | |
Gene Alias | KLK-L2 | |
Cytomap | 19q13.41 | |
Gene Type | protein-coding | GO ID | GO:0002225 | UniProtAcc | Q9Y337 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25818 | KLK5 | GSM4909281 | Human | Breast | IDC | 1.52e-09 | 5.20e-01 | 0.21 |
25818 | KLK5 | GSM4909285 | Human | Breast | IDC | 1.72e-05 | -1.40e-01 | 0.21 |
25818 | KLK5 | GSM4909286 | Human | Breast | IDC | 7.79e-05 | -1.43e-01 | 0.1081 |
25818 | KLK5 | GSM4909290 | Human | Breast | IDC | 5.07e-03 | -1.44e-01 | 0.2096 |
25818 | KLK5 | GSM4909294 | Human | Breast | IDC | 2.56e-02 | -1.28e-01 | 0.2022 |
25818 | KLK5 | GSM4909299 | Human | Breast | IDC | 8.13e-05 | 3.63e-01 | 0.035 |
25818 | KLK5 | GSM4909301 | Human | Breast | IDC | 3.66e-05 | -1.44e-01 | 0.1577 |
25818 | KLK5 | GSM4909304 | Human | Breast | IDC | 7.79e-05 | -1.44e-01 | 0.1636 |
25818 | KLK5 | GSM4909308 | Human | Breast | IDC | 3.00e-04 | -1.44e-01 | 0.158 |
25818 | KLK5 | GSM4909312 | Human | Breast | IDC | 1.72e-05 | -1.44e-01 | 0.1552 |
25818 | KLK5 | GSM4909319 | Human | Breast | IDC | 3.51e-04 | -1.44e-01 | 0.1563 |
25818 | KLK5 | GSM4909321 | Human | Breast | IDC | 7.79e-05 | -1.44e-01 | 0.1559 |
25818 | KLK5 | brca1 | Human | Breast | Precancer | 7.91e-25 | 7.61e-01 | -0.0338 |
25818 | KLK5 | brca10 | Human | Breast | Precancer | 4.88e-04 | -1.44e-01 | -0.0029 |
25818 | KLK5 | NCCBC5 | Human | Breast | DCIS | 2.81e-03 | -1.44e-01 | 0.2046 |
25818 | KLK5 | P1 | Human | Breast | IDC | 4.96e-03 | -1.20e-01 | 0.1527 |
25818 | KLK5 | DCIS2 | Human | Breast | DCIS | 5.40e-51 | 7.35e-01 | 0.0085 |
25818 | KLK5 | LZE22T | Human | Esophagus | ESCC | 1.34e-10 | 1.85e+00 | 0.068 |
25818 | KLK5 | LZE6T | Human | Esophagus | ESCC | 1.29e-05 | 2.50e-01 | 0.0845 |
25818 | KLK5 | P10T-E | Human | Esophagus | ESCC | 4.78e-10 | 7.36e-01 | 0.116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00321034 | Breast | Precancer | positive regulation of response to external stimulus | 46/1080 | 427/18723 | 3.41e-05 | 7.40e-04 | 46 |
GO:00313493 | Breast | Precancer | positive regulation of defense response | 33/1080 | 278/18723 | 6.79e-05 | 1.36e-03 | 33 |
GO:00197307 | Breast | Precancer | antimicrobial humoral response | 19/1080 | 122/18723 | 7.02e-05 | 1.40e-03 | 19 |
GO:00618446 | Breast | Precancer | antimicrobial humoral immune response mediated by antimicrobial peptide | 14/1080 | 79/18723 | 1.53e-04 | 2.61e-03 | 14 |
GO:00085445 | Breast | Precancer | epidermis development | 35/1080 | 324/18723 | 2.71e-04 | 3.96e-03 | 35 |
GO:00224119 | Breast | Precancer | cellular component disassembly | 44/1080 | 443/18723 | 3.17e-04 | 4.51e-03 | 44 |
GO:00099136 | Breast | Precancer | epidermal cell differentiation | 23/1080 | 202/18723 | 1.43e-03 | 1.50e-02 | 23 |
GO:00302163 | Breast | Precancer | keratinocyte differentiation | 17/1080 | 139/18723 | 2.71e-03 | 2.39e-02 | 17 |
GO:001973011 | Breast | IDC | antimicrobial humoral response | 23/1434 | 122/18723 | 4.67e-05 | 1.04e-03 | 23 |
GO:00313491 | Breast | IDC | positive regulation of defense response | 39/1434 | 278/18723 | 1.74e-04 | 2.95e-03 | 39 |
GO:003210311 | Breast | IDC | positive regulation of response to external stimulus | 54/1434 | 427/18723 | 1.85e-04 | 3.07e-03 | 54 |
GO:006184411 | Breast | IDC | antimicrobial humoral immune response mediated by antimicrobial peptide | 16/1434 | 79/18723 | 2.75e-04 | 4.24e-03 | 16 |
GO:000854412 | Breast | IDC | epidermis development | 41/1434 | 324/18723 | 1.03e-03 | 1.14e-02 | 41 |
GO:00069596 | Breast | IDC | humoral immune response | 40/1434 | 317/18723 | 1.25e-03 | 1.33e-02 | 40 |
GO:000991312 | Breast | IDC | epidermal cell differentiation | 28/1434 | 202/18723 | 1.62e-03 | 1.60e-02 | 28 |
GO:00302161 | Breast | IDC | keratinocyte differentiation | 21/1434 | 139/18723 | 2.06e-03 | 1.95e-02 | 21 |
GO:00435883 | Breast | IDC | skin development | 33/1434 | 263/18723 | 3.46e-03 | 2.87e-02 | 33 |
GO:003210321 | Breast | DCIS | positive regulation of response to external stimulus | 54/1390 | 427/18723 | 8.34e-05 | 1.58e-03 | 54 |
GO:00313492 | Breast | DCIS | positive regulation of defense response | 38/1390 | 278/18723 | 1.91e-04 | 3.08e-03 | 38 |
GO:001973021 | Breast | DCIS | antimicrobial humoral response | 21/1390 | 122/18723 | 2.40e-04 | 3.75e-03 | 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLK5 | SNV | Missense_Mutation | rs200140569 | c.491G>A | p.Arg164His | p.R164H | Q9Y337 | protein_coding | tolerated(0.61) | possibly_damaging(0.846) | TCGA-49-AARO-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
KLK5 | SNV | Missense_Mutation | c.207N>G | p.Asn69Lys | p.N69K | Q9Y337 | protein_coding | tolerated(0.32) | benign(0.289) | TCGA-4B-A93V-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
KLK5 | SNV | Missense_Mutation | c.109N>A | p.His37Asn | p.H37N | Q9Y337 | protein_coding | tolerated(1) | benign(0) | TCGA-55-1595-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KLK5 | SNV | Missense_Mutation | c.197N>T | p.Arg66Leu | p.R66L | Q9Y337 | protein_coding | tolerated(0.08) | benign(0.442) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
KLK5 | SNV | Missense_Mutation | novel | c.320N>A | p.Ala107Asp | p.A107D | Q9Y337 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-69-8253-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
KLK5 | SNV | Missense_Mutation | rs541541684 | c.371N>T | p.Ser124Leu | p.S124L | Q9Y337 | protein_coding | tolerated(0.12) | possibly_damaging(0.488) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD |
KLK5 | SNV | Missense_Mutation | novel | c.707C>A | p.Ala236Glu | p.A236E | Q9Y337 | protein_coding | tolerated(0.92) | benign(0.003) | TCGA-33-AASJ-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
KLK5 | SNV | Missense_Mutation | c.368N>A | p.Leu123Gln | p.L123Q | Q9Y337 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-60-2713-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | gemzar | SD | |
KLK5 | SNV | Missense_Mutation | c.136A>T | p.Ser46Cys | p.S46C | Q9Y337 | protein_coding | deleterious(0.01) | benign(0.319) | TCGA-66-2780-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KLK5 | SNV | Missense_Mutation | rs754078347 | c.674T>C | p.Ile225Thr | p.I225T | Q9Y337 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-77-7465-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
25818 | KLK5 | PROTEASE, DRUGGABLE GENOME, ENZYME | inhibitor | 252166696 | ||
25818 | KLK5 | PROTEASE, DRUGGABLE GENOME, ENZYME | inhibitor | 252166691 |
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