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Gene: KIF14 |
Gene summary for KIF14 |
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Gene information | Species | Human | Gene symbol | KIF14 | Gene ID | 9928 |
Gene name | kinesin family member 14 | |
Gene Alias | MCPH20 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q15058 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9928 | KIF14 | LZE2T | Human | Esophagus | ESCC | 4.73e-03 | 4.63e-01 | 0.082 |
9928 | KIF14 | LZE7T | Human | Esophagus | ESCC | 1.02e-03 | 2.11e-01 | 0.0667 |
9928 | KIF14 | P1T-E | Human | Esophagus | ESCC | 7.11e-04 | 3.96e-01 | 0.0875 |
9928 | KIF14 | P2T-E | Human | Esophagus | ESCC | 9.35e-10 | 3.64e-01 | 0.1177 |
9928 | KIF14 | P4T-E | Human | Esophagus | ESCC | 1.78e-10 | 3.32e-01 | 0.1323 |
9928 | KIF14 | P5T-E | Human | Esophagus | ESCC | 5.79e-16 | 6.76e-01 | 0.1327 |
9928 | KIF14 | P9T-E | Human | Esophagus | ESCC | 1.88e-05 | 1.93e-01 | 0.1131 |
9928 | KIF14 | P10T-E | Human | Esophagus | ESCC | 2.02e-06 | 2.66e-01 | 0.116 |
9928 | KIF14 | P15T-E | Human | Esophagus | ESCC | 2.11e-03 | 1.50e-01 | 0.1149 |
9928 | KIF14 | P16T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.53e-01 | 0.1153 |
9928 | KIF14 | P20T-E | Human | Esophagus | ESCC | 3.97e-02 | 1.63e-01 | 0.1124 |
9928 | KIF14 | P21T-E | Human | Esophagus | ESCC | 3.89e-12 | 3.90e-01 | 0.1617 |
9928 | KIF14 | P22T-E | Human | Esophagus | ESCC | 4.17e-05 | 2.55e-01 | 0.1236 |
9928 | KIF14 | P24T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.60e-01 | 0.1287 |
9928 | KIF14 | P26T-E | Human | Esophagus | ESCC | 9.20e-06 | 2.34e-01 | 0.1276 |
9928 | KIF14 | P28T-E | Human | Esophagus | ESCC | 4.44e-08 | 2.97e-01 | 0.1149 |
9928 | KIF14 | P31T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.96e-01 | 0.1251 |
9928 | KIF14 | P32T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.73e-01 | 0.1666 |
9928 | KIF14 | P37T-E | Human | Esophagus | ESCC | 1.42e-10 | 3.14e-01 | 0.1371 |
9928 | KIF14 | P42T-E | Human | Esophagus | ESCC | 9.05e-04 | 2.08e-01 | 0.1175 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:005131011 | Esophagus | ESCC | metaphase plate congression | 58/8552 | 65/18723 | 1.81e-13 | 8.63e-12 | 58 |
GO:000708011 | Esophagus | ESCC | mitotic metaphase plate congression | 47/8552 | 50/18723 | 3.15e-13 | 1.47e-11 | 47 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
GO:005130311 | Esophagus | ESCC | establishment of chromosome localization | 67/8552 | 80/18723 | 1.92e-12 | 8.09e-11 | 67 |
GO:005000011 | Esophagus | ESCC | chromosome localization | 68/8552 | 82/18723 | 3.37e-12 | 1.32e-10 | 68 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:190199013 | Esophagus | ESCC | regulation of mitotic cell cycle phase transition | 191/8552 | 299/18723 | 1.35e-10 | 3.94e-09 | 191 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF14 | SNV | Missense_Mutation | c.3593N>T | p.Arg1198Ile | p.R1198I | Q15058 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
KIF14 | SNV | Missense_Mutation | c.1406N>T | p.Arg469Ile | p.R469I | Q15058 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
KIF14 | SNV | Missense_Mutation | novel | c.189N>G | p.Ile63Met | p.I63M | Q15058 | protein_coding | deleterious(0.03) | benign(0.023) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
KIF14 | SNV | Missense_Mutation | c.3707N>T | p.Ser1236Phe | p.S1236F | Q15058 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-DM-A28F-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
KIF14 | SNV | Missense_Mutation | c.1396A>C | p.Ile466Leu | p.I466L | Q15058 | protein_coding | deleterious(0.03) | possibly_damaging(0.557) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KIF14 | SNV | Missense_Mutation | novel | c.3758T>G | p.Phe1253Cys | p.F1253C | Q15058 | protein_coding | deleterious(0) | benign(0.112) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIF14 | SNV | Missense_Mutation | rs373895990 | c.1793G>A | p.Arg598Gln | p.R598Q | Q15058 | protein_coding | deleterious(0.01) | probably_damaging(0.979) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIF14 | SNV | Missense_Mutation | rs371145728 | c.1669G>A | p.Ala557Thr | p.A557T | Q15058 | protein_coding | deleterious(0) | possibly_damaging(0.627) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIF14 | SNV | Missense_Mutation | novel | c.1503A>C | p.Lys501Asn | p.K501N | Q15058 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIF14 | SNV | Missense_Mutation | novel | c.4040A>C | p.Lys1347Thr | p.K1347T | Q15058 | protein_coding | tolerated(0.12) | benign(0.022) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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