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Gene: KIAA1147 |
Gene summary for KIAA1147 |
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Gene information | Species | Human | Gene symbol | KIAA1147 | Gene ID | 57189 |
Gene name | DENN domain containing 11 | |
Gene Alias | KIAA1147 | |
Cytomap | 7q34 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A4D1U4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57189 | KIAA1147 | HCC1_Meng | Human | Liver | HCC | 1.70e-13 | 1.37e-02 | 0.0246 |
57189 | KIAA1147 | HCC2_Meng | Human | Liver | HCC | 2.32e-14 | 1.15e-01 | 0.0107 |
57189 | KIAA1147 | HCC1 | Human | Liver | HCC | 5.57e-05 | 2.14e+00 | 0.5336 |
57189 | KIAA1147 | HCC2 | Human | Liver | HCC | 9.26e-19 | 2.84e+00 | 0.5341 |
57189 | KIAA1147 | Pt14.a | Human | Liver | HCC | 1.50e-10 | 4.37e-01 | 0.0169 |
57189 | KIAA1147 | S014 | Human | Liver | HCC | 4.80e-08 | 2.63e-01 | 0.2254 |
57189 | KIAA1147 | S015 | Human | Liver | HCC | 1.78e-03 | 1.79e-01 | 0.2375 |
57189 | KIAA1147 | S016 | Human | Liver | HCC | 8.48e-12 | 2.86e-01 | 0.2243 |
57189 | KIAA1147 | S027 | Human | Liver | HCC | 5.77e-10 | 5.61e-01 | 0.2446 |
57189 | KIAA1147 | S028 | Human | Liver | HCC | 7.26e-19 | 4.98e-01 | 0.2503 |
57189 | KIAA1147 | S029 | Human | Liver | HCC | 3.46e-18 | 5.60e-01 | 0.2581 |
57189 | KIAA1147 | Dong_P1 | Human | Prostate | Tumor | 5.06e-10 | 1.07e-01 | 0.035 |
57189 | KIAA1147 | Dong_P3 | Human | Prostate | Tumor | 3.81e-06 | 8.87e-02 | 0.0278 |
57189 | KIAA1147 | Dong_P5 | Human | Prostate | Tumor | 2.16e-03 | 3.62e-02 | 0.053 |
57189 | KIAA1147 | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 2.22e-03 | 4.94e-01 | 0.159 |
57189 | KIAA1147 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 3.76e-15 | 5.74e-01 | 0.1633 |
57189 | KIAA1147 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 2.29e-20 | 6.02e-01 | 0.1608 |
57189 | KIAA1147 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 6.09e-10 | 4.88e-01 | 0.1604 |
57189 | KIAA1147 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 3.08e-06 | 3.30e-01 | 0.1621 |
57189 | KIAA1147 | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 3.50e-02 | 2.66e-01 | 0.1619 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease | ||
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA1147 | SNV | Missense_Mutation | novel | c.851N>T | p.Ser284Leu | p.S284L | A4D1U4 | protein_coding | deleterious(0.03) | benign(0.179) | TCGA-90-7964-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KIAA1147 | SNV | Missense_Mutation | novel | c.949N>A | p.Ala317Thr | p.A317T | A4D1U4 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-QK-A6VB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KIAA1147 | SNV | Missense_Mutation | novel | c.505N>G | p.His169Asp | p.H169D | A4D1U4 | protein_coding | tolerated(0.29) | benign(0.025) | TCGA-EJ-A8FS-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | PD |
KIAA1147 | SNV | Missense_Mutation | rs768326324 | c.907N>A | p.Val303Met | p.V303M | A4D1U4 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KIAA1147 | SNV | Missense_Mutation | novel | c.469C>A | p.Leu157Ile | p.L157I | A4D1U4 | protein_coding | tolerated(0.05) | benign(0.286) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
KIAA1147 | SNV | Missense_Mutation | novel | c.983N>T | p.Arg328Leu | p.R328L | A4D1U4 | protein_coding | tolerated(0.19) | benign(0.082) | TCGA-ET-A39R-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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