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Gene: KIAA0930 |
Gene summary for KIAA0930 |
Gene summary. |
Gene information | Species | Human | Gene symbol | KIAA0930 | Gene ID | 23313 |
Gene name | KIAA0930 | |
Gene Alias | C22orf9 | |
Cytomap | 22q13.31 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q6ICG6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23313 | KIAA0930 | LZE4T | Human | Esophagus | ESCC | 2.52e-06 | 7.87e-02 | 0.0811 |
23313 | KIAA0930 | LZE5T | Human | Esophagus | ESCC | 1.62e-03 | 4.96e-02 | 0.0514 |
23313 | KIAA0930 | LZE7T | Human | Esophagus | ESCC | 5.65e-06 | 3.91e-01 | 0.0667 |
23313 | KIAA0930 | LZE20T | Human | Esophagus | ESCC | 1.74e-03 | 2.45e-02 | 0.0662 |
23313 | KIAA0930 | LZE22T | Human | Esophagus | ESCC | 1.12e-04 | 7.87e-02 | 0.068 |
23313 | KIAA0930 | LZE24T | Human | Esophagus | ESCC | 8.02e-11 | 3.26e-02 | 0.0596 |
23313 | KIAA0930 | LZE6T | Human | Esophagus | ESCC | 4.47e-03 | -5.03e-02 | 0.0845 |
23313 | KIAA0930 | P1T-E | Human | Esophagus | ESCC | 6.15e-04 | 3.22e-01 | 0.0875 |
23313 | KIAA0930 | P2T-E | Human | Esophagus | ESCC | 1.21e-09 | -2.74e-02 | 0.1177 |
23313 | KIAA0930 | P4T-E | Human | Esophagus | ESCC | 3.95e-10 | 2.59e-01 | 0.1323 |
23313 | KIAA0930 | P5T-E | Human | Esophagus | ESCC | 2.29e-16 | 8.61e-03 | 0.1327 |
23313 | KIAA0930 | P8T-E | Human | Esophagus | ESCC | 6.10e-15 | 1.04e-01 | 0.0889 |
23313 | KIAA0930 | P9T-E | Human | Esophagus | ESCC | 5.88e-15 | 2.06e-01 | 0.1131 |
23313 | KIAA0930 | P10T-E | Human | Esophagus | ESCC | 1.44e-14 | 1.63e-01 | 0.116 |
23313 | KIAA0930 | P11T-E | Human | Esophagus | ESCC | 1.01e-06 | 3.18e-01 | 0.1426 |
23313 | KIAA0930 | P12T-E | Human | Esophagus | ESCC | 1.71e-22 | 2.22e-01 | 0.1122 |
23313 | KIAA0930 | P15T-E | Human | Esophagus | ESCC | 8.67e-16 | 2.94e-01 | 0.1149 |
23313 | KIAA0930 | P16T-E | Human | Esophagus | ESCC | 1.42e-07 | -5.34e-02 | 0.1153 |
23313 | KIAA0930 | P17T-E | Human | Esophagus | ESCC | 1.65e-10 | 2.28e-01 | 0.1278 |
23313 | KIAA0930 | P19T-E | Human | Esophagus | ESCC | 4.84e-03 | 2.03e-01 | 0.1662 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA0930 | SNV | Missense_Mutation | novel | c.97N>T | p.Arg33Cys | p.R33C | Q6ICG6 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIAA0930 | SNV | Missense_Mutation | c.541N>A | p.Asp181Asn | p.D181N | Q6ICG6 | protein_coding | deleterious(0) | possibly_damaging(0.689) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIAA0930 | SNV | Missense_Mutation | c.374N>T | p.Ala125Val | p.A125V | Q6ICG6 | protein_coding | deleterious(0) | possibly_damaging(0.781) | TCGA-D1-A17U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
KIAA0930 | SNV | Missense_Mutation | novel | c.1200N>C | p.Glu400Asp | p.E400D | Q6ICG6 | protein_coding | tolerated(0.18) | benign(0.058) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIAA0930 | SNV | Missense_Mutation | c.103N>A | p.Val35Ile | p.V35I | Q6ICG6 | protein_coding | deleterious(0.01) | possibly_damaging(0.881) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIAA0930 | SNV | Missense_Mutation | rs763982974 | c.163N>A | p.Asp55Asn | p.D55N | Q6ICG6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
KIAA0930 | SNV | Missense_Mutation | c.528N>T | p.Glu176Asp | p.E176D | Q6ICG6 | protein_coding | tolerated(0.42) | benign(0.038) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
KIAA0930 | SNV | Missense_Mutation | c.68G>T | p.Gly23Val | p.G23V | Q6ICG6 | protein_coding | tolerated_low_confidence(0.08) | benign(0.191) | TCGA-75-5126-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | SD | |
KIAA0930 | SNV | Missense_Mutation | c.879C>A | p.Phe293Leu | p.F293L | Q6ICG6 | protein_coding | tolerated(0.08) | benign(0.337) | TCGA-86-6851-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIAA0930 | SNV | Missense_Mutation | novel | c.1018N>T | p.Asp340Tyr | p.D340Y | Q6ICG6 | protein_coding | deleterious(0.01) | probably_damaging(0.91) | TCGA-95-A4VN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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