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Gene: KCNJ5 |
Gene summary for KCNJ5 |
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Gene information | Species | Human | Gene symbol | KCNJ5 | Gene ID | 3762 |
Gene name | potassium inwardly rectifying channel subfamily J member 5 | |
Gene Alias | CIR | |
Cytomap | 11q24.3 | |
Gene Type | protein-coding | GO ID | GO:0001508 | UniProtAcc | P48544 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3762 | KCNJ5 | HCC1 | Human | Liver | HCC | 5.48e-23 | 2.99e+00 | 0.5336 |
3762 | KCNJ5 | HCC2 | Human | Liver | HCC | 1.97e-32 | 2.23e+00 | 0.5341 |
3762 | KCNJ5 | HCC5 | Human | Liver | HCC | 1.25e-40 | 2.13e+00 | 0.4932 |
3762 | KCNJ5 | S029 | Human | Liver | HCC | 2.88e-04 | 2.58e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCNJ5 | SNV | Missense_Mutation | c.185N>C | p.Val62Ala | p.V62A | P48544 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
KCNJ5 | SNV | Missense_Mutation | rs142140011 | c.89G>A | p.Arg30His | p.R30H | P48544 | protein_coding | deleterious(0) | possibly_damaging(0.879) | TCGA-DF-A2KV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KCNJ5 | SNV | Missense_Mutation | novel | c.193G>A | p.Gly65Ser | p.G65S | P48544 | protein_coding | tolerated(0.12) | probably_damaging(1) | TCGA-EO-A22S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KCNJ5 | SNV | Missense_Mutation | novel | c.817C>T | p.Pro273Ser | p.P273S | P48544 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KCNJ5 | SNV | Missense_Mutation | novel | c.229N>A | p.Leu77Ile | p.L77I | P48544 | protein_coding | tolerated(1) | benign(0.173) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KCNJ5 | SNV | Missense_Mutation | rs369247802 | c.344G>A | p.Arg115Gln | p.R115Q | P48544 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
KCNJ5 | SNV | Missense_Mutation | rs185412918 | c.119N>T | p.Thr40Met | p.T40M | P48544 | protein_coding | tolerated(0.13) | possibly_damaging(0.828) | TCGA-FI-A2D6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KCNJ5 | SNV | Missense_Mutation | novel | c.386G>T | p.Cys129Phe | p.C129F | P48544 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-7281-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
KCNJ5 | SNV | Missense_Mutation | c.424T>G | p.Phe142Val | p.F142V | P48544 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-64-1679-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
KCNJ5 | SNV | Missense_Mutation | rs756845312 | c.1116N>C | p.Arg372Ser | p.R372S | P48544 | protein_coding | tolerated(0.98) | benign(0.001) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3762 | KCNJ5 | TRANSPORTER, ION CHANNEL, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | FLUPIRTINE | FLUPIRTINE | ||
3762 | KCNJ5 | TRANSPORTER, ION CHANNEL, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | activator | 135652743 | ||
3762 | KCNJ5 | TRANSPORTER, ION CHANNEL, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | blocker | 135650721 | ||
3762 | KCNJ5 | TRANSPORTER, ION CHANNEL, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | phorbol 12-myristate 13-acetate | |||
3762 | KCNJ5 | TRANSPORTER, ION CHANNEL, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | blocker | 223366037 | ||
3762 | KCNJ5 | TRANSPORTER, ION CHANNEL, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | activator | 135651544 |
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