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Gene: KCNAB2 |
Gene summary for KCNAB2 |
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Gene information | Species | Human | Gene symbol | KCNAB2 | Gene ID | 8514 |
Gene name | potassium voltage-gated channel subfamily A regulatory beta subunit 2 | |
Gene Alias | AKR6A5 | |
Cytomap | 1p36.31 | |
Gene Type | protein-coding | GO ID | GO:0001508 | UniProtAcc | A0A024R4E3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8514 | KCNAB2 | HCC2 | Human | Liver | HCC | 7.14e-06 | 3.12e+00 | 0.5341 |
8514 | KCNAB2 | S014 | Human | Liver | HCC | 1.43e-07 | 4.16e-01 | 0.2254 |
8514 | KCNAB2 | S015 | Human | Liver | HCC | 1.70e-07 | 5.72e-01 | 0.2375 |
8514 | KCNAB2 | S016 | Human | Liver | HCC | 6.14e-18 | 7.03e-01 | 0.2243 |
8514 | KCNAB2 | S028 | Human | Liver | HCC | 3.24e-04 | 3.16e-01 | 0.2503 |
8514 | KCNAB2 | S029 | Human | Liver | HCC | 1.49e-09 | 4.44e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006739 | Liver | HCC | NADP metabolic process | 25/7958 | 35/18723 | 5.05e-04 | 3.29e-03 | 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KCNAB2 | SNV | Missense_Mutation | rs754826043 | c.53N>T | p.Thr18Met | p.T18M | Q13303 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.791) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
KCNAB2 | SNV | Missense_Mutation | rs777718700 | c.64N>A | p.Gly22Arg | p.G22R | Q13303 | protein_coding | deleterious_low_confidence(0.01) | benign(0.415) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
KCNAB2 | SNV | Missense_Mutation | novel | c.392T>C | p.Val131Ala | p.V131A | Q13303 | protein_coding | tolerated(0.2) | benign(0.066) | TCGA-VQ-A8DU-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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