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Gene: ITGB4 |
Gene summary for ITGB4 |
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Gene information | Species | Human | Gene symbol | ITGB4 | Gene ID | 3691 |
Gene name | integrin subunit beta 4 | |
Gene Alias | CD104 | |
Cytomap | 17q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R8T0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3691 | ITGB4 | CA_HPV_1 | Human | Cervix | CC | 1.09e-12 | -3.88e-01 | 0.0264 |
3691 | ITGB4 | CA_HPV_3 | Human | Cervix | CC | 3.22e-03 | 3.06e-02 | 0.0414 |
3691 | ITGB4 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 5.84e-04 | -2.94e-01 | 0.0116 |
3691 | ITGB4 | N_HPV_1 | Human | Cervix | N_HPV | 3.30e-02 | -2.72e-01 | 0.0079 |
3691 | ITGB4 | CCII_1 | Human | Cervix | CC | 8.34e-31 | 1.25e+00 | 0.3249 |
3691 | ITGB4 | Tumor | Human | Cervix | CC | 1.51e-12 | 4.34e-01 | 0.1241 |
3691 | ITGB4 | sample3 | Human | Cervix | CC | 1.45e-27 | 6.04e-01 | 0.1387 |
3691 | ITGB4 | T1 | Human | Cervix | CC | 4.65e-05 | 3.86e-01 | 0.0918 |
3691 | ITGB4 | T3 | Human | Cervix | CC | 5.10e-24 | 5.79e-01 | 0.1389 |
3691 | ITGB4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.55e-08 | 3.65e-01 | 0.0155 |
3691 | ITGB4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.26e-23 | 1.17e+00 | -0.1808 |
3691 | ITGB4 | HTA11_2951_2000001011 | Human | Colorectum | AD | 5.97e-05 | 8.07e-01 | 0.0216 |
3691 | ITGB4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.12e-23 | 1.14e+00 | -0.0811 |
3691 | ITGB4 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.23e-10 | 7.13e-01 | -0.1088 |
3691 | ITGB4 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.50e-28 | 7.81e-01 | -0.1954 |
3691 | ITGB4 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.33e-12 | 1.77e+00 | -0.2602 |
3691 | ITGB4 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.59e-08 | 1.18e+00 | -0.2196 |
3691 | ITGB4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.64e-12 | 6.63e-01 | -0.1207 |
3691 | ITGB4 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.66e-07 | 5.78e-01 | -0.1526 |
3691 | ITGB4 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.74e-30 | 9.24e-01 | -0.1464 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00315898 | Cervix | CC | cell-substrate adhesion | 96/2311 | 363/18723 | 1.48e-13 | 8.85e-11 | 96 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:00435884 | Cervix | CC | skin development | 71/2311 | 263/18723 | 8.04e-11 | 1.46e-08 | 71 |
GO:01501159 | Cervix | CC | cell-substrate junction organization | 37/2311 | 101/18723 | 3.20e-10 | 4.46e-08 | 37 |
GO:00070448 | Cervix | CC | cell-substrate junction assembly | 34/2311 | 95/18723 | 3.35e-09 | 3.45e-07 | 34 |
GO:00071608 | Cervix | CC | cell-matrix adhesion | 60/2311 | 233/18723 | 1.58e-08 | 1.23e-06 | 60 |
GO:00072295 | Cervix | CC | integrin-mediated signaling pathway | 34/2311 | 107/18723 | 1.01e-07 | 5.25e-06 | 34 |
GO:00343298 | Cervix | CC | cell junction assembly | 88/2311 | 420/18723 | 3.42e-07 | 1.38e-05 | 88 |
GO:00435893 | Cervix | CC | skin morphogenesis | 8/2311 | 11/18723 | 6.22e-06 | 1.51e-04 | 8 |
GO:00073695 | Cervix | CC | gastrulation | 42/2311 | 185/18723 | 5.83e-05 | 8.46e-04 | 42 |
GO:00075654 | Cervix | CC | female pregnancy | 43/2311 | 193/18723 | 7.62e-05 | 1.04e-03 | 43 |
GO:00447064 | Cervix | CC | multi-multicellular organism process | 45/2311 | 220/18723 | 4.14e-04 | 4.21e-03 | 45 |
GO:00336272 | Cervix | CC | cell adhesion mediated by integrin | 19/2311 | 72/18723 | 9.11e-04 | 7.81e-03 | 19 |
GO:00075664 | Cervix | CC | embryo implantation | 15/2311 | 53/18723 | 1.43e-03 | 1.12e-02 | 15 |
GO:0001704 | Cervix | CC | formation of primary germ layer | 27/2311 | 121/18723 | 1.49e-03 | 1.16e-02 | 27 |
GO:00487365 | Cervix | CC | appendage development | 35/2311 | 172/18723 | 1.88e-03 | 1.39e-02 | 35 |
GO:00601735 | Cervix | CC | limb development | 35/2311 | 172/18723 | 1.88e-03 | 1.39e-02 | 35 |
GO:00614502 | Cervix | CC | trophoblast cell migration | 7/2311 | 17/18723 | 2.72e-03 | 1.85e-02 | 7 |
GO:000722913 | Cervix | HSIL_HPV | integrin-mediated signaling pathway | 19/737 | 107/18723 | 3.37e-08 | 2.76e-06 | 19 |
GO:000756512 | Cervix | HSIL_HPV | female pregnancy | 26/737 | 193/18723 | 4.32e-08 | 3.41e-06 | 26 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0451010 | Cervix | CC | Focal adhesion | 59/1267 | 203/8465 | 1.53e-07 | 1.84e-06 | 1.09e-06 | 59 |
hsa0481016 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa051657 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
hsa0451014 | Cervix | CC | Focal adhesion | 59/1267 | 203/8465 | 1.53e-07 | 1.84e-06 | 1.09e-06 | 59 |
hsa0481017 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa0516512 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
hsa045124 | Cervix | HSIL_HPV | ECM-receptor interaction | 12/459 | 89/8465 | 2.95e-03 | 1.88e-02 | 1.52e-02 | 12 |
hsa0451023 | Cervix | HSIL_HPV | Focal adhesion | 21/459 | 203/8465 | 3.24e-03 | 2.02e-02 | 1.63e-02 | 21 |
hsa054127 | Cervix | HSIL_HPV | Arrhythmogenic right ventricular cardiomyopathy | 10/459 | 77/8465 | 8.34e-03 | 4.70e-02 | 3.80e-02 | 10 |
hsa0451211 | Cervix | HSIL_HPV | ECM-receptor interaction | 12/459 | 89/8465 | 2.95e-03 | 1.88e-02 | 1.52e-02 | 12 |
hsa0451033 | Cervix | HSIL_HPV | Focal adhesion | 21/459 | 203/8465 | 3.24e-03 | 2.02e-02 | 1.63e-02 | 21 |
hsa0541212 | Cervix | HSIL_HPV | Arrhythmogenic right ventricular cardiomyopathy | 10/459 | 77/8465 | 8.34e-03 | 4.70e-02 | 3.80e-02 | 10 |
hsa04810 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa04510 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa048101 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa045101 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa048102 | Colorectum | SER | Regulation of actin cytoskeleton | 60/1580 | 229/8465 | 2.74e-03 | 2.02e-02 | 1.47e-02 | 60 |
hsa048103 | Colorectum | SER | Regulation of actin cytoskeleton | 60/1580 | 229/8465 | 2.74e-03 | 2.02e-02 | 1.47e-02 | 60 |
hsa048104 | Colorectum | MSS | Regulation of actin cytoskeleton | 68/1875 | 229/8465 | 4.27e-03 | 1.86e-02 | 1.14e-02 | 68 |
hsa048105 | Colorectum | MSS | Regulation of actin cytoskeleton | 68/1875 | 229/8465 | 4.27e-03 | 1.86e-02 | 1.14e-02 | 68 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
LAMA2 | ITGA6_ITGB4 | LAMA2_ITGA6_ITGB4 | LAMININ | Breast | DCIS |
LAMA3 | ITGA6_ITGB4 | LAMA3_ITGA6_ITGB4 | LAMININ | Breast | DCIS |
LAMA4 | ITGA6_ITGB4 | LAMA4_ITGA6_ITGB4 | LAMININ | Breast | DCIS |
LAMB1 | ITGA6_ITGB4 | LAMB1_ITGA6_ITGB4 | LAMININ | Breast | DCIS |
LAMB2 | ITGA6_ITGB4 | LAMB2_ITGA6_ITGB4 | LAMININ | Breast | DCIS |
LAMC1 | ITGA6_ITGB4 | LAMC1_ITGA6_ITGB4 | LAMININ | Breast | DCIS |
IGF1 | ITGA6_ITGB4 | IGF1_ITGA6_ITGB4 | IGF | Breast | DCIS |
LAMA2 | ITGA6_ITGB4 | LAMA2_ITGA6_ITGB4 | LAMININ | Cervix | ADJ |
LAMA3 | ITGA6_ITGB4 | LAMA3_ITGA6_ITGB4 | LAMININ | Cervix | ADJ |
LAMA4 | ITGA6_ITGB4 | LAMA4_ITGA6_ITGB4 | LAMININ | Cervix | ADJ |
LAMA5 | ITGA6_ITGB4 | LAMA5_ITGA6_ITGB4 | LAMININ | Cervix | ADJ |
LAMB1 | ITGA6_ITGB4 | LAMB1_ITGA6_ITGB4 | LAMININ | Cervix | ADJ |
LAMB2 | ITGA6_ITGB4 | LAMB2_ITGA6_ITGB4 | LAMININ | Cervix | ADJ |
LAMB3 | ITGA6_ITGB4 | LAMB3_ITGA6_ITGB4 | LAMININ | Cervix | ADJ |
LAMC1 | ITGA6_ITGB4 | LAMC1_ITGA6_ITGB4 | LAMININ | Cervix | ADJ |
LAMC2 | ITGA6_ITGB4 | LAMC2_ITGA6_ITGB4 | LAMININ | Cervix | ADJ |
IGF1 | ITGA6_ITGB4 | IGF1_ITGA6_ITGB4 | IGF | Cervix | ADJ |
LAMA2 | ITGA6_ITGB4 | LAMA2_ITGA6_ITGB4 | LAMININ | Cervix | CC |
LAMA3 | ITGA6_ITGB4 | LAMA3_ITGA6_ITGB4 | LAMININ | Cervix | CC |
LAMA4 | ITGA6_ITGB4 | LAMA4_ITGA6_ITGB4 | LAMININ | Cervix | CC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITGB4 | SNV | Missense_Mutation | c.2078N>A | p.Gly693Glu | p.G693E | P16144 | protein_coding | tolerated(0.27) | benign(0.065) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ITGB4 | SNV | Missense_Mutation | c.2963N>A | p.Ala988Asp | p.A988D | P16144 | protein_coding | deleterious(0.02) | benign(0.053) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ITGB4 | SNV | Missense_Mutation | c.512T>C | p.Phe171Ser | p.F171S | P16144 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ITGB4 | SNV | Missense_Mutation | c.5189G>A | p.Gly1730Asp | p.G1730D | P16144 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ITGB4 | SNV | Missense_Mutation | rs149608383 | c.2530C>T | p.Arg844Cys | p.R844C | P16144 | protein_coding | deleterious(0) | possibly_damaging(0.863) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ITGB4 | SNV | Missense_Mutation | c.594N>A | p.Asp198Glu | p.D198E | P16144 | protein_coding | tolerated(0.08) | possibly_damaging(0.906) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ITGB4 | SNV | Missense_Mutation | c.2254G>A | p.Gly752Ser | p.G752S | P16144 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
ITGB4 | SNV | Missense_Mutation | rs772928070 | c.2971G>A | p.Val991Met | p.V991M | P16144 | protein_coding | tolerated(0.06) | possibly_damaging(0.542) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
ITGB4 | SNV | Missense_Mutation | rs149353166 | c.5107N>A | p.Val1703Met | p.V1703M | P16144 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ITGB4 | SNV | Missense_Mutation | c.1602N>C | p.Gln534His | p.Q534H | P16144 | protein_coding | tolerated(0.16) | benign(0.001) | TCGA-AG-3881-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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