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Gene: ITFG2 |
Gene summary for ITFG2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ITFG2 | Gene ID | 55846 |
Gene name | integrin alpha FG-GAP repeat containing 2 | |
Gene Alias | FGGAP1 | |
Cytomap | 12p13.33 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | A0A0S2Z5P1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55846 | ITFG2 | CCI_2 | Human | Cervix | CC | 8.22e-05 | 5.85e-01 | 0.5249 |
55846 | ITFG2 | CCI_3 | Human | Cervix | CC | 9.83e-12 | 7.11e-01 | 0.516 |
55846 | ITFG2 | LZE4T | Human | Esophagus | ESCC | 4.37e-02 | 1.38e-01 | 0.0811 |
55846 | ITFG2 | LZE7T | Human | Esophagus | ESCC | 3.27e-03 | 2.59e-01 | 0.0667 |
55846 | ITFG2 | LZE8T | Human | Esophagus | ESCC | 5.08e-03 | 1.65e-01 | 0.067 |
55846 | ITFG2 | LZE20T | Human | Esophagus | ESCC | 2.36e-02 | 1.84e-01 | 0.0662 |
55846 | ITFG2 | LZE22T | Human | Esophagus | ESCC | 2.75e-05 | 2.84e-01 | 0.068 |
55846 | ITFG2 | LZE24T | Human | Esophagus | ESCC | 8.85e-04 | 1.67e-01 | 0.0596 |
55846 | ITFG2 | P1T-E | Human | Esophagus | ESCC | 4.74e-06 | 4.07e-01 | 0.0875 |
55846 | ITFG2 | P2T-E | Human | Esophagus | ESCC | 7.18e-39 | 6.75e-01 | 0.1177 |
55846 | ITFG2 | P4T-E | Human | Esophagus | ESCC | 6.46e-17 | 4.46e-01 | 0.1323 |
55846 | ITFG2 | P5T-E | Human | Esophagus | ESCC | 4.95e-05 | 1.38e-01 | 0.1327 |
55846 | ITFG2 | P8T-E | Human | Esophagus | ESCC | 1.75e-13 | 2.73e-01 | 0.0889 |
55846 | ITFG2 | P9T-E | Human | Esophagus | ESCC | 4.04e-06 | 1.31e-01 | 0.1131 |
55846 | ITFG2 | P10T-E | Human | Esophagus | ESCC | 1.39e-25 | 4.95e-01 | 0.116 |
55846 | ITFG2 | P11T-E | Human | Esophagus | ESCC | 3.92e-12 | 3.25e-01 | 0.1426 |
55846 | ITFG2 | P12T-E | Human | Esophagus | ESCC | 4.69e-30 | 5.68e-01 | 0.1122 |
55846 | ITFG2 | P15T-E | Human | Esophagus | ESCC | 5.39e-10 | 2.33e-01 | 0.1149 |
55846 | ITFG2 | P16T-E | Human | Esophagus | ESCC | 4.54e-17 | 3.41e-01 | 0.1153 |
55846 | ITFG2 | P17T-E | Human | Esophagus | ESCC | 8.94e-08 | 3.19e-01 | 0.1278 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007149610 | Cervix | CC | cellular response to external stimulus | 78/2311 | 320/18723 | 1.82e-09 | 1.98e-07 | 78 |
GO:00316689 | Cervix | CC | cellular response to extracellular stimulus | 59/2311 | 246/18723 | 3.03e-07 | 1.24e-05 | 59 |
GO:003166710 | Cervix | CC | response to nutrient levels | 92/2311 | 474/18723 | 5.80e-06 | 1.42e-04 | 92 |
GO:00092678 | Cervix | CC | cellular response to starvation | 39/2311 | 156/18723 | 1.04e-05 | 2.32e-04 | 39 |
GO:00425948 | Cervix | CC | response to starvation | 46/2311 | 197/18723 | 1.24e-05 | 2.59e-04 | 46 |
GO:00316698 | Cervix | CC | cellular response to nutrient levels | 49/2311 | 215/18723 | 1.32e-05 | 2.68e-04 | 49 |
GO:19031314 | Cervix | CC | mononuclear cell differentiation | 76/2311 | 426/18723 | 5.66e-04 | 5.42e-03 | 76 |
GO:0002263 | Cervix | CC | cell activation involved in immune response | 50/2311 | 279/18723 | 4.16e-03 | 2.57e-02 | 50 |
GO:00300981 | Cervix | CC | lymphocyte differentiation | 63/2311 | 374/18723 | 6.21e-03 | 3.52e-02 | 63 |
GO:0071496111 | Esophagus | ESCC | cellular response to external stimulus | 215/8552 | 320/18723 | 4.29e-15 | 2.43e-13 | 215 |
GO:0031668111 | Esophagus | ESCC | cellular response to extracellular stimulus | 168/8552 | 246/18723 | 4.93e-13 | 2.23e-11 | 168 |
GO:0031669110 | Esophagus | ESCC | cellular response to nutrient levels | 148/8552 | 215/18723 | 4.58e-12 | 1.76e-10 | 148 |
GO:0031667111 | Esophagus | ESCC | response to nutrient levels | 289/8552 | 474/18723 | 9.25e-12 | 3.47e-10 | 289 |
GO:0009267110 | Esophagus | ESCC | cellular response to starvation | 110/8552 | 156/18723 | 2.63e-10 | 7.37e-09 | 110 |
GO:004259419 | Esophagus | ESCC | response to starvation | 133/8552 | 197/18723 | 4.31e-10 | 1.14e-08 | 133 |
GO:19909284 | Esophagus | ESCC | response to amino acid starvation | 37/8552 | 49/18723 | 2.05e-05 | 1.78e-04 | 37 |
GO:00421492 | Esophagus | ESCC | cellular response to glucose starvation | 36/8552 | 48/18723 | 3.43e-05 | 2.80e-04 | 36 |
GO:00319294 | Esophagus | ESCC | TOR signaling | 79/8552 | 126/18723 | 8.57e-05 | 6.21e-04 | 79 |
GO:00341984 | Esophagus | ESCC | cellular response to amino acid starvation | 34/8552 | 46/18723 | 9.39e-05 | 6.70e-04 | 34 |
GO:19031317 | Esophagus | ESCC | mononuclear cell differentiation | 226/8552 | 426/18723 | 1.20e-03 | 5.88e-03 | 226 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITFG2 | SNV | Missense_Mutation | c.422G>C | p.Arg141Pro | p.R141P | Q969R8 | protein_coding | tolerated(0.19) | benign(0.029) | TCGA-34-5929-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ITFG2 | SNV | Missense_Mutation | c.1216N>T | p.Ser406Cys | p.S406C | Q969R8 | protein_coding | tolerated(0.07) | benign(0.001) | TCGA-39-5039-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ITFG2 | SNV | Missense_Mutation | novel | c.289N>A | p.Pro97Thr | p.P97T | Q969R8 | protein_coding | tolerated(0.15) | benign(0.036) | TCGA-56-7223-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ITFG2 | SNV | Missense_Mutation | novel | c.673N>A | p.Glu225Lys | p.E225K | Q969R8 | protein_coding | tolerated(0.22) | benign(0.039) | TCGA-56-7822-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | eloxatin | PD |
ITFG2 | SNV | Missense_Mutation | novel | c.661C>T | p.Pro221Ser | p.P221S | Q969R8 | protein_coding | tolerated(0.7) | benign(0) | TCGA-77-8153-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ITFG2 | SNV | Missense_Mutation | novel | c.635G>C | p.Cys212Ser | p.C212S | Q969R8 | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-85-8355-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ITFG2 | SNV | Missense_Mutation | novel | c.85N>C | p.Asp29His | p.D29H | Q969R8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CV-A6K2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ITFG2 | SNV | Missense_Mutation | novel | c.55T>G | p.Phe19Val | p.F19V | Q969R8 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
ITFG2 | SNV | Missense_Mutation | c.431N>C | p.Val144Ala | p.V144A | Q969R8 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ITFG2 | SNV | Missense_Mutation | c.524N>C | p.Lys175Thr | p.K175T | Q969R8 | protein_coding | deleterious(0.03) | probably_damaging(0.994) | TCGA-CD-5801-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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