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Gene: IQGAP2 |
Gene summary for IQGAP2 |
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Gene information | Species | Human | Gene symbol | IQGAP2 | Gene ID | 10788 |
Gene name | IQ motif containing GTPase activating protein 2 | |
Gene Alias | IQGAP2 | |
Cytomap | 5q13.3 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | B7Z7U6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10788 | IQGAP2 | CA_HPV_1 | Human | Cervix | CC | 1.65e-05 | -2.59e-02 | 0.0264 |
10788 | IQGAP2 | CCI_1 | Human | Cervix | CC | 2.35e-04 | -4.88e-01 | 0.528 |
10788 | IQGAP2 | CCII_1 | Human | Cervix | CC | 1.21e-10 | -4.97e-01 | 0.3249 |
10788 | IQGAP2 | Tumor | Human | Cervix | CC | 2.00e-29 | -5.08e-01 | 0.1241 |
10788 | IQGAP2 | sample1 | Human | Cervix | CC | 1.32e-05 | -4.57e-01 | 0.0959 |
10788 | IQGAP2 | sample3 | Human | Cervix | CC | 8.06e-30 | -5.08e-01 | 0.1387 |
10788 | IQGAP2 | L1 | Human | Cervix | CC | 2.62e-09 | -4.68e-01 | 0.0802 |
10788 | IQGAP2 | T1 | Human | Cervix | CC | 2.21e-17 | -4.80e-01 | 0.0918 |
10788 | IQGAP2 | T3 | Human | Cervix | CC | 2.08e-31 | -5.06e-01 | 0.1389 |
10788 | IQGAP2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.29e-15 | -6.36e-01 | 0.0155 |
10788 | IQGAP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.85e-11 | 6.55e-01 | -0.1954 |
10788 | IQGAP2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.36e-14 | -7.03e-01 | 0.096 |
10788 | IQGAP2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 3.72e-02 | -8.37e-01 | 0.0451 |
10788 | IQGAP2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.84e-03 | -6.32e-01 | 0.0528 |
10788 | IQGAP2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.07e-06 | -5.91e-01 | 0.0338 |
10788 | IQGAP2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.77e-09 | -4.63e-01 | 0.0674 |
10788 | IQGAP2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.09e-31 | -7.95e-01 | 0.294 |
10788 | IQGAP2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.60e-09 | -4.65e-01 | 0.3859 |
10788 | IQGAP2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.84e-11 | -8.71e-01 | 0.2585 |
10788 | IQGAP2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.82e-37 | -8.62e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000701510 | Cervix | CC | actin filament organization | 109/2311 | 442/18723 | 4.92e-13 | 2.45e-10 | 109 |
GO:003297010 | Cervix | CC | regulation of actin filament-based process | 96/2311 | 397/18723 | 4.00e-11 | 8.54e-09 | 96 |
GO:190290310 | Cervix | CC | regulation of supramolecular fiber organization | 92/2311 | 383/18723 | 1.49e-10 | 2.48e-08 | 92 |
GO:003295610 | Cervix | CC | regulation of actin cytoskeleton organization | 86/2311 | 358/18723 | 5.90e-10 | 7.51e-08 | 86 |
GO:004325410 | Cervix | CC | regulation of protein-containing complex assembly | 96/2311 | 428/18723 | 2.91e-09 | 3.05e-07 | 96 |
GO:011005310 | Cervix | CC | regulation of actin filament organization | 67/2311 | 278/18723 | 4.01e-08 | 2.54e-06 | 67 |
GO:00430877 | Cervix | CC | regulation of GTPase activity | 79/2311 | 348/18723 | 4.21e-08 | 2.60e-06 | 79 |
GO:005125810 | Cervix | CC | protein polymerization | 70/2311 | 297/18723 | 5.20e-08 | 3.11e-06 | 70 |
GO:003227110 | Cervix | CC | regulation of protein polymerization | 57/2311 | 233/18723 | 2.37e-07 | 1.03e-05 | 57 |
GO:003133410 | Cervix | CC | positive regulation of protein-containing complex assembly | 55/2311 | 237/18723 | 2.25e-06 | 6.73e-05 | 55 |
GO:190290510 | Cervix | CC | positive regulation of supramolecular fiber organization | 50/2311 | 209/18723 | 2.55e-06 | 7.54e-05 | 50 |
GO:00315328 | Cervix | CC | actin cytoskeleton reorganization | 31/2311 | 107/18723 | 3.34e-06 | 8.99e-05 | 31 |
GO:00081549 | Cervix | CC | actin polymerization or depolymerization | 51/2311 | 218/18723 | 4.05e-06 | 1.05e-04 | 51 |
GO:00300419 | Cervix | CC | actin filament polymerization | 45/2311 | 191/18723 | 1.20e-05 | 2.54e-04 | 45 |
GO:00325359 | Cervix | CC | regulation of cellular component size | 76/2311 | 383/18723 | 1.66e-05 | 3.21e-04 | 76 |
GO:005149510 | Cervix | CC | positive regulation of cytoskeleton organization | 50/2311 | 226/18723 | 2.53e-05 | 4.29e-04 | 50 |
GO:00308339 | Cervix | CC | regulation of actin filament polymerization | 40/2311 | 172/18723 | 4.90e-05 | 7.40e-04 | 40 |
GO:00080649 | Cervix | CC | regulation of actin polymerization or depolymerization | 42/2311 | 188/18723 | 8.60e-05 | 1.15e-03 | 42 |
GO:00308328 | Cervix | CC | regulation of actin filament length | 42/2311 | 189/18723 | 9.76e-05 | 1.27e-03 | 42 |
GO:003227310 | Cervix | CC | positive regulation of protein polymerization | 33/2311 | 138/18723 | 1.23e-04 | 1.53e-03 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0481016 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa0481017 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa04810 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa048101 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa048102 | Colorectum | SER | Regulation of actin cytoskeleton | 60/1580 | 229/8465 | 2.74e-03 | 2.02e-02 | 1.47e-02 | 60 |
hsa048103 | Colorectum | SER | Regulation of actin cytoskeleton | 60/1580 | 229/8465 | 2.74e-03 | 2.02e-02 | 1.47e-02 | 60 |
hsa048104 | Colorectum | MSS | Regulation of actin cytoskeleton | 68/1875 | 229/8465 | 4.27e-03 | 1.86e-02 | 1.14e-02 | 68 |
hsa048105 | Colorectum | MSS | Regulation of actin cytoskeleton | 68/1875 | 229/8465 | 4.27e-03 | 1.86e-02 | 1.14e-02 | 68 |
hsa048106 | Colorectum | FAP | Regulation of actin cytoskeleton | 65/1404 | 229/8465 | 4.07e-06 | 5.91e-05 | 3.59e-05 | 65 |
hsa048107 | Colorectum | FAP | Regulation of actin cytoskeleton | 65/1404 | 229/8465 | 4.07e-06 | 5.91e-05 | 3.59e-05 | 65 |
hsa048108 | Colorectum | CRC | Regulation of actin cytoskeleton | 52/1091 | 229/8465 | 2.34e-05 | 5.57e-04 | 3.78e-04 | 52 |
hsa048109 | Colorectum | CRC | Regulation of actin cytoskeleton | 52/1091 | 229/8465 | 2.34e-05 | 5.57e-04 | 3.78e-04 | 52 |
hsa0481018 | Endometrium | AEH | Regulation of actin cytoskeleton | 50/1197 | 229/8465 | 9.08e-04 | 5.78e-03 | 4.23e-03 | 50 |
hsa0481019 | Endometrium | AEH | Regulation of actin cytoskeleton | 50/1197 | 229/8465 | 9.08e-04 | 5.78e-03 | 4.23e-03 | 50 |
hsa0481024 | Endometrium | EEC | Regulation of actin cytoskeleton | 49/1237 | 229/8465 | 3.20e-03 | 1.78e-02 | 1.33e-02 | 49 |
hsa0481034 | Endometrium | EEC | Regulation of actin cytoskeleton | 49/1237 | 229/8465 | 3.20e-03 | 1.78e-02 | 1.33e-02 | 49 |
hsa0481010 | Liver | NAFLD | Regulation of actin cytoskeleton | 50/1043 | 229/8465 | 3.01e-05 | 7.59e-04 | 6.11e-04 | 50 |
hsa0481011 | Liver | NAFLD | Regulation of actin cytoskeleton | 50/1043 | 229/8465 | 3.01e-05 | 7.59e-04 | 6.11e-04 | 50 |
hsa0481021 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
hsa0481031 | Liver | Cirrhotic | Regulation of actin cytoskeleton | 100/2530 | 229/8465 | 5.28e-06 | 5.50e-05 | 3.39e-05 | 100 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IQGAP2 | SNV | Missense_Mutation | c.1082N>T | p.Ala361Val | p.A361V | Q13576 | protein_coding | tolerated(0.17) | benign(0.039) | TCGA-EI-6881-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5 | SD | |
IQGAP2 | SNV | Missense_Mutation | novel | c.1636N>C | p.Asn546His | p.N546H | Q13576 | protein_coding | deleterious(0) | possibly_damaging(0.841) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IQGAP2 | SNV | Missense_Mutation | rs534842328 | c.2353N>T | p.Arg785Cys | p.R785C | Q13576 | protein_coding | tolerated(0.07) | possibly_damaging(0.516) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IQGAP2 | SNV | Missense_Mutation | c.4364N>T | p.Arg1455Ile | p.R1455I | Q13576 | protein_coding | tolerated(0.24) | benign(0.021) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
IQGAP2 | SNV | Missense_Mutation | rs199687430 | c.4502N>G | p.Asn1501Ser | p.N1501S | Q13576 | protein_coding | tolerated(0.69) | benign(0.048) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IQGAP2 | insertion | Frame_Shift_Ins | novel | c.4493_4494insCCGAG | p.Gln1499ArgfsTer15 | p.Q1499Rfs*15 | Q13576 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
IQGAP2 | deletion | Frame_Shift_Del | c.1819delN | p.Lys608AsnfsTer42 | p.K608Nfs*42 | Q13576 | protein_coding | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
IQGAP2 | deletion | Frame_Shift_Del | c.2641delA | p.Thr881HisfsTer2 | p.T881Hfs*2 | Q13576 | protein_coding | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
IQGAP2 | deletion | Frame_Shift_Del | c.2637delN | p.Thr881HisfsTer2 | p.T881Hfs*2 | Q13576 | protein_coding | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
IQGAP2 | SNV | Missense_Mutation | novel | c.824N>T | p.Ser275Ile | p.S275I | Q13576 | protein_coding | tolerated(0.21) | benign(0.01) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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