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Gene: IPCEF1 |
Gene summary for IPCEF1 |
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Gene information | Species | Human | Gene symbol | IPCEF1 | Gene ID | 26034 |
Gene name | interaction protein for cytohesin exchange factors 1 | |
Gene Alias | PIP3-E | |
Cytomap | 6q25.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8WWN9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26034 | IPCEF1 | RNA-P3T-P3T-4 | Human | Lung | IAC | 1.67e-02 | 2.86e-01 | 0.1859 |
26034 | IPCEF1 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.57e-19 | 6.42e-01 | -0.0166 |
26034 | IPCEF1 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 3.46e-17 | 5.60e-01 | -0.0132 |
26034 | IPCEF1 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 2.03e-21 | 6.45e-01 | -0.013 |
26034 | IPCEF1 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 5.08e-19 | 6.15e-01 | -0.0121 |
26034 | IPCEF1 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 1.98e-07 | 8.24e-01 | -0.0961 |
26034 | IPCEF1 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 8.10e-12 | 9.54e-01 | -0.0876 |
26034 | IPCEF1 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 7.13e-10 | 9.49e-01 | -0.0822 |
26034 | IPCEF1 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 6.36e-10 | 8.72e-01 | -0.0809 |
26034 | IPCEF1 | PTCwithHT_6 | Human | Thyroid | HT | 1.15e-03 | -2.88e-01 | 0.02 |
26034 | IPCEF1 | male-WTA | Human | Thyroid | PTC | 1.84e-02 | -1.54e-01 | 0.1037 |
26034 | IPCEF1 | PTC06 | Human | Thyroid | PTC | 2.99e-03 | -2.34e-01 | 0.2057 |
26034 | IPCEF1 | PTC07 | Human | Thyroid | PTC | 6.08e-07 | -2.07e-01 | 0.2044 |
26034 | IPCEF1 | ATC13 | Human | Thyroid | ATC | 1.09e-02 | -2.84e-01 | 0.34 |
26034 | IPCEF1 | ATC4 | Human | Thyroid | ATC | 2.36e-04 | -2.91e-01 | 0.34 |
26034 | IPCEF1 | ATC5 | Human | Thyroid | ATC | 4.15e-03 | -2.83e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069798 | Lung | IAC | response to oxidative stress | 82/2061 | 446/18723 | 1.99e-06 | 9.18e-05 | 82 |
GO:000697913 | Lung | AIS | response to oxidative stress | 75/1849 | 446/18723 | 2.97e-06 | 1.60e-04 | 75 |
GO:000697930 | Thyroid | HT | response to oxidative stress | 81/1272 | 446/18723 | 2.53e-16 | 1.17e-13 | 81 |
GO:000963627 | Thyroid | HT | response to toxic substance | 50/1272 | 262/18723 | 2.25e-11 | 3.75e-09 | 50 |
GO:199074827 | Thyroid | HT | cellular detoxification | 31/1272 | 116/18723 | 2.29e-11 | 3.75e-09 | 31 |
GO:009875420 | Thyroid | HT | detoxification | 36/1272 | 152/18723 | 2.63e-11 | 4.07e-09 | 36 |
GO:009723727 | Thyroid | HT | cellular response to toxic substance | 32/1272 | 124/18723 | 3.00e-11 | 4.51e-09 | 32 |
GO:009886926 | Thyroid | HT | cellular oxidant detoxification | 26/1272 | 101/18723 | 2.23e-09 | 2.26e-07 | 26 |
GO:0006979113 | Thyroid | PTC | response to oxidative stress | 234/5968 | 446/18723 | 6.97e-20 | 9.77e-18 | 234 |
GO:0009636111 | Thyroid | PTC | response to toxic substance | 115/5968 | 262/18723 | 2.70e-05 | 2.63e-04 | 115 |
GO:1990748112 | Thyroid | PTC | cellular detoxification | 56/5968 | 116/18723 | 1.63e-04 | 1.26e-03 | 56 |
GO:0097237112 | Thyroid | PTC | cellular response to toxic substance | 59/5968 | 124/18723 | 1.83e-04 | 1.39e-03 | 59 |
GO:0098869111 | Thyroid | PTC | cellular oxidant detoxification | 49/5968 | 101/18723 | 3.52e-04 | 2.41e-03 | 49 |
GO:0098754110 | Thyroid | PTC | detoxification | 63/5968 | 152/18723 | 7.92e-03 | 3.34e-02 | 63 |
GO:000697934 | Thyroid | ATC | response to oxidative stress | 246/6293 | 446/18723 | 2.98e-21 | 6.09e-19 | 246 |
GO:000963634 | Thyroid | ATC | response to toxic substance | 119/6293 | 262/18723 | 4.30e-05 | 3.48e-04 | 119 |
GO:199074833 | Thyroid | ATC | cellular detoxification | 58/6293 | 116/18723 | 1.88e-04 | 1.26e-03 | 58 |
GO:009723733 | Thyroid | ATC | cellular response to toxic substance | 61/6293 | 124/18723 | 2.31e-04 | 1.49e-03 | 61 |
GO:009886932 | Thyroid | ATC | cellular oxidant detoxification | 51/6293 | 101/18723 | 3.29e-04 | 2.05e-03 | 51 |
GO:009875433 | Thyroid | ATC | detoxification | 66/6293 | 152/18723 | 7.23e-03 | 2.85e-02 | 66 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IPCEF1 | insertion | Frame_Shift_Ins | novel | c.317_318insA | p.His107AlafsTer4 | p.H107Afs*4 | Q8WWN9 | protein_coding | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
IPCEF1 | SNV | Missense_Mutation | novel | c.1121N>C | p.Leu374Pro | p.L374P | Q8WWN9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2Y-A9GU-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IPCEF1 | SNV | Missense_Mutation | c.200G>T | p.Trp67Leu | p.W67L | Q8WWN9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-44-8117-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
IPCEF1 | SNV | Missense_Mutation | rs751364357 | c.95G>A | p.Arg32Gln | p.R32Q | Q8WWN9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD |
IPCEF1 | SNV | Missense_Mutation | novel | c.85N>T | p.Thr29Ser | p.T29S | Q8WWN9 | protein_coding | tolerated(0.22) | benign(0.013) | TCGA-21-1083-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IPCEF1 | SNV | Missense_Mutation | novel | c.1068A>T | p.Lys356Asn | p.K356N | Q8WWN9 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-22-1002-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IPCEF1 | SNV | Missense_Mutation | novel | c.998G>T | p.Arg333Leu | p.R333L | Q8WWN9 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-43-A475-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
IPCEF1 | SNV | Missense_Mutation | novel | c.26N>T | p.Gly9Val | p.G9V | Q8WWN9 | protein_coding | deleterious(0.01) | possibly_damaging(0.732) | TCGA-56-8628-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IPCEF1 | SNV | Missense_Mutation | novel | c.1078N>G | p.Ile360Val | p.I360V | Q8WWN9 | protein_coding | tolerated(0.12) | benign(0.078) | TCGA-85-8287-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IPCEF1 | SNV | Missense_Mutation | novel | c.953N>T | p.Tyr318Phe | p.Y318F | Q8WWN9 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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