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Gene: ILF2 |
Gene summary for ILF2 |
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Gene information | Species | Human | Gene symbol | ILF2 | Gene ID | 3608 |
Gene name | interleukin enhancer binding factor 2 | |
Gene Alias | NF45 | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B4DY09 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3608 | ILF2 | GSM4909285 | Human | Breast | IDC | 3.38e-16 | 5.76e-01 | 0.21 |
3608 | ILF2 | GSM4909286 | Human | Breast | IDC | 8.80e-05 | -1.95e-01 | 0.1081 |
3608 | ILF2 | GSM4909287 | Human | Breast | IDC | 7.24e-08 | 3.85e-01 | 0.2057 |
3608 | ILF2 | GSM4909294 | Human | Breast | IDC | 1.55e-04 | -5.81e-02 | 0.2022 |
3608 | ILF2 | GSM4909296 | Human | Breast | IDC | 5.13e-20 | -4.10e-01 | 0.1524 |
3608 | ILF2 | GSM4909297 | Human | Breast | IDC | 2.32e-18 | -3.24e-01 | 0.1517 |
3608 | ILF2 | GSM4909298 | Human | Breast | IDC | 3.36e-04 | -2.20e-01 | 0.1551 |
3608 | ILF2 | GSM4909301 | Human | Breast | IDC | 1.41e-35 | -5.45e-01 | 0.1577 |
3608 | ILF2 | GSM4909302 | Human | Breast | IDC | 1.57e-05 | -3.82e-01 | 0.1545 |
3608 | ILF2 | GSM4909311 | Human | Breast | IDC | 7.31e-42 | -4.08e-01 | 0.1534 |
3608 | ILF2 | GSM4909312 | Human | Breast | IDC | 9.90e-13 | -1.41e-01 | 0.1552 |
3608 | ILF2 | GSM4909318 | Human | Breast | IDC | 1.92e-02 | 2.43e-01 | 0.2031 |
3608 | ILF2 | GSM4909319 | Human | Breast | IDC | 8.85e-41 | -4.73e-01 | 0.1563 |
3608 | ILF2 | GSM4909320 | Human | Breast | IDC | 1.54e-05 | -5.13e-01 | 0.1575 |
3608 | ILF2 | GSM4909321 | Human | Breast | IDC | 1.80e-15 | -1.31e-01 | 0.1559 |
3608 | ILF2 | brca1 | Human | Breast | Precancer | 2.10e-16 | 4.83e-01 | -0.0338 |
3608 | ILF2 | brca2 | Human | Breast | Precancer | 7.26e-04 | 3.47e-01 | -0.024 |
3608 | ILF2 | brca3 | Human | Breast | Precancer | 1.09e-03 | 3.10e-01 | -0.0263 |
3608 | ILF2 | M2 | Human | Breast | IDC | 6.78e-06 | 3.62e-01 | 0.21 |
3608 | ILF2 | NCCBC14 | Human | Breast | DCIS | 4.73e-11 | 1.24e-01 | 0.2021 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ILF2 | SNV | Missense_Mutation | novel | c.712G>C | p.Glu238Gln | p.E238Q | Q12905 | protein_coding | tolerated(0.52) | benign(0.288) | TCGA-33-AASJ-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ILF2 | SNV | Missense_Mutation | novel | c.535N>G | p.Thr179Ala | p.T179A | Q12905 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-85-6798-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | PD |
ILF2 | SNV | Missense_Mutation | novel | c.1133N>G | p.Pro378Arg | p.P378R | Q12905 | protein_coding | tolerated_low_confidence(0.17) | probably_damaging(0.954) | TCGA-KU-A6H7-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ILF2 | SNV | Missense_Mutation | c.401N>T | p.Ala134Val | p.A134V | Q12905 | protein_coding | deleterious(0.03) | benign(0.281) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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