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Gene: IL17RE |
Gene summary for IL17RE |
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Gene information | Species | Human | Gene symbol | IL17RE | Gene ID | 132014 |
Gene name | interleukin 17 receptor E | |
Gene Alias | IL17RE | |
Cytomap | 3p25.3 | |
Gene Type | protein-coding | GO ID | GO:0006950 | UniProtAcc | B4DMZ3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
132014 | IL17RE | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.49e-05 | 4.12e-01 | -0.1808 |
132014 | IL17RE | HTA11_78_2000001011 | Human | Colorectum | AD | 1.66e-08 | 4.58e-01 | -0.1088 |
132014 | IL17RE | HTA11_347_2000001011 | Human | Colorectum | AD | 4.33e-30 | 7.58e-01 | -0.1954 |
132014 | IL17RE | HTA11_411_2000001011 | Human | Colorectum | SER | 1.27e-07 | 1.38e+00 | -0.2602 |
132014 | IL17RE | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.49e-04 | 7.26e-01 | -0.2196 |
132014 | IL17RE | HTA11_83_2000001011 | Human | Colorectum | SER | 2.80e-02 | 3.13e-01 | -0.1526 |
132014 | IL17RE | HTA11_696_2000001011 | Human | Colorectum | AD | 2.20e-12 | 6.69e-01 | -0.1464 |
132014 | IL17RE | HTA11_866_2000001011 | Human | Colorectum | AD | 8.57e-07 | 4.47e-01 | -0.1001 |
132014 | IL17RE | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.78e-07 | 4.18e-01 | -0.059 |
132014 | IL17RE | HTA11_546_2000001011 | Human | Colorectum | AD | 5.77e-05 | 4.76e-01 | -0.0842 |
132014 | IL17RE | HTA11_10623_2000001011 | Human | Colorectum | AD | 5.87e-04 | 3.71e-01 | -0.0177 |
132014 | IL17RE | HTA11_6818_2000001011 | Human | Colorectum | AD | 4.16e-04 | 4.99e-01 | 0.0112 |
132014 | IL17RE | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.77e-02 | 8.45e-01 | 0.3487 |
132014 | IL17RE | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.60e-02 | 3.22e-01 | 0.281 |
132014 | IL17RE | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.41e-04 | 3.77e-01 | 0.3859 |
132014 | IL17RE | A015-C-203 | Human | Colorectum | FAP | 1.51e-07 | -2.09e-01 | -0.1294 |
132014 | IL17RE | A002-C-201 | Human | Colorectum | FAP | 4.27e-03 | -2.52e-01 | 0.0324 |
132014 | IL17RE | A001-C-108 | Human | Colorectum | FAP | 1.85e-04 | -2.22e-01 | -0.0272 |
132014 | IL17RE | A002-C-205 | Human | Colorectum | FAP | 1.23e-03 | -2.39e-01 | -0.1236 |
132014 | IL17RE | A015-C-106 | Human | Colorectum | FAP | 1.73e-04 | -1.35e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0465727 | Esophagus | ESCC | IL-17 signaling pathway | 66/4205 | 94/8465 | 3.93e-05 | 1.75e-04 | 8.99e-05 | 66 |
hsa0465734 | Esophagus | ESCC | IL-17 signaling pathway | 66/4205 | 94/8465 | 3.93e-05 | 1.75e-04 | 8.99e-05 | 66 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IL17RE | SNV | Missense_Mutation | novel | c.1453N>A | p.Gly485Ser | p.G485S | Q8NFR9 | protein_coding | tolerated(0.78) | benign(0.086) | TCGA-69-A59K-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
IL17RE | SNV | Missense_Mutation | novel | c.691N>T | p.Val231Leu | p.V231L | Q8NFR9 | protein_coding | deleterious(0.03) | benign(0.112) | TCGA-83-5908-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IL17RE | SNV | Missense_Mutation | novel | c.682N>T | p.Gly228Cys | p.G228C | Q8NFR9 | protein_coding | deleterious(0) | possibly_damaging(0.87) | TCGA-18-3414-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
IL17RE | SNV | Missense_Mutation | novel | c.1090A>G | p.Asn364Asp | p.N364D | Q8NFR9 | protein_coding | deleterious(0.01) | possibly_damaging(0.536) | TCGA-22-1002-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IL17RE | SNV | Missense_Mutation | c.144N>G | p.Phe48Leu | p.F48L | Q8NFR9 | protein_coding | tolerated_low_confidence(0.4) | benign(0.003) | TCGA-60-2698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | mithramycin | PD | |
IL17RE | SNV | Missense_Mutation | novel | c.701C>T | p.Pro234Leu | p.P234L | Q8NFR9 | protein_coding | deleterious(0.02) | benign(0.439) | TCGA-85-8049-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IL17RE | SNV | Missense_Mutation | novel | c.118N>G | p.Leu40Val | p.L40V | Q8NFR9 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.681) | TCGA-CR-7390-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IL17RE | SNV | Missense_Mutation | novel | c.146C>A | p.Thr49Asn | p.T49N | Q8NFR9 | protein_coding | deleterious_low_confidence(0.04) | benign(0.037) | TCGA-CV-5444-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IL17RE | SNV | Missense_Mutation | c.1040A>G | p.Asn347Ser | p.N347S | Q8NFR9 | protein_coding | tolerated(0.06) | benign(0.432) | TCGA-BR-6705-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
IL17RE | SNV | Missense_Mutation | novel | c.809N>T | p.Ser270Leu | p.S270L | Q8NFR9 | protein_coding | tolerated(0.11) | benign(0.11) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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