|
Gene: IFRD2 |
Gene summary for IFRD2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | IFRD2 | Gene ID | 7866 |
Gene name | interferon related developmental regulator 2 | |
Gene Alias | IFNRP | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q12894 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7866 | IFRD2 | LZE7T | Human | Esophagus | ESCC | 1.64e-04 | 2.77e-01 | 0.0667 |
7866 | IFRD2 | LZE24T | Human | Esophagus | ESCC | 9.55e-14 | 3.86e-01 | 0.0596 |
7866 | IFRD2 | LZE6T | Human | Esophagus | ESCC | 3.73e-02 | 6.62e-02 | 0.0845 |
7866 | IFRD2 | P1T-E | Human | Esophagus | ESCC | 1.77e-07 | 4.02e-01 | 0.0875 |
7866 | IFRD2 | P2T-E | Human | Esophagus | ESCC | 5.24e-29 | 2.41e-01 | 0.1177 |
7866 | IFRD2 | P4T-E | Human | Esophagus | ESCC | 2.71e-21 | 6.96e-01 | 0.1323 |
7866 | IFRD2 | P5T-E | Human | Esophagus | ESCC | 3.64e-16 | 4.77e-01 | 0.1327 |
7866 | IFRD2 | P8T-E | Human | Esophagus | ESCC | 3.65e-23 | 1.83e-01 | 0.0889 |
7866 | IFRD2 | P9T-E | Human | Esophagus | ESCC | 1.30e-17 | 4.68e-01 | 0.1131 |
7866 | IFRD2 | P10T-E | Human | Esophagus | ESCC | 6.31e-21 | 3.62e-01 | 0.116 |
7866 | IFRD2 | P11T-E | Human | Esophagus | ESCC | 2.22e-11 | 4.77e-01 | 0.1426 |
7866 | IFRD2 | P12T-E | Human | Esophagus | ESCC | 6.10e-26 | 4.27e-01 | 0.1122 |
7866 | IFRD2 | P15T-E | Human | Esophagus | ESCC | 2.37e-12 | 2.47e-01 | 0.1149 |
7866 | IFRD2 | P16T-E | Human | Esophagus | ESCC | 2.84e-21 | 4.74e-01 | 0.1153 |
7866 | IFRD2 | P17T-E | Human | Esophagus | ESCC | 1.51e-04 | 5.38e-01 | 0.1278 |
7866 | IFRD2 | P19T-E | Human | Esophagus | ESCC | 4.27e-07 | 9.22e-01 | 0.1662 |
7866 | IFRD2 | P20T-E | Human | Esophagus | ESCC | 3.93e-09 | 2.74e-01 | 0.1124 |
7866 | IFRD2 | P21T-E | Human | Esophagus | ESCC | 5.16e-40 | 9.24e-01 | 0.1617 |
7866 | IFRD2 | P22T-E | Human | Esophagus | ESCC | 8.42e-20 | 3.44e-01 | 0.1236 |
7866 | IFRD2 | P23T-E | Human | Esophagus | ESCC | 9.05e-25 | 6.90e-01 | 0.108 |
Page: 1 2 3 4 5 6 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFRD2 | SNV | Missense_Mutation | novel | c.797N>C | p.Val266Ala | p.V266A | Q12894 | protein_coding | tolerated(0.24) | benign(0.412) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
IFRD2 | SNV | Missense_Mutation | novel | c.455N>T | p.Ser152Ile | p.S152I | Q12894 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IFRD2 | SNV | Missense_Mutation | novel | c.643N>T | p.Pro215Ser | p.P215S | Q12894 | protein_coding | tolerated(0.81) | benign(0.031) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IFRD2 | SNV | Missense_Mutation | rs782596548 | c.731G>A | p.Arg244Gln | p.R244Q | Q12894 | protein_coding | deleterious(0.01) | probably_damaging(0.978) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IFRD2 | SNV | Missense_Mutation | rs782142071 | c.1282N>T | p.Arg428Trp | p.R428W | Q12894 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IFRD2 | SNV | Missense_Mutation | novel | c.28N>T | p.Pro10Ser | p.P10S | Q12894 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.994) | TCGA-FI-A2F9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IFRD2 | deletion | Frame_Shift_Del | c.376delN | p.Asp126MetfsTer16 | p.D126Mfs*16 | Q12894 | protein_coding | TCGA-AP-A0LP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Hormone Therapy | megace | SD | |||
IFRD2 | deletion | Frame_Shift_Del | c.376delN | p.Asp126MetfsTer16 | p.D126Mfs*16 | Q12894 | protein_coding | TCGA-BG-A3EW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |||
IFRD2 | SNV | Missense_Mutation | c.292N>C | p.Asp98His | p.D98H | Q12894 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CC-A9FW-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
IFRD2 | SNV | Missense_Mutation | c.453N>T | p.Lys151Asn | p.K151N | Q12894 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-50-6591-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |