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Gene: IBA57 |
Gene summary for IBA57 |
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Gene information | Species | Human | Gene symbol | IBA57 | Gene ID | 200205 |
Gene name | iron-sulfur cluster assembly factor IBA57 | |
Gene Alias | C1orf69 | |
Cytomap | 1q42.13 | |
Gene Type | protein-coding | GO ID | GO:0006725 | UniProtAcc | Q5T440 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
200205 | IBA57 | HCC1_Meng | Human | Liver | HCC | 3.58e-14 | -2.46e-02 | 0.0246 |
200205 | IBA57 | HCC1 | Human | Liver | HCC | 7.09e-27 | 3.11e+00 | 0.5336 |
200205 | IBA57 | HCC2 | Human | Liver | HCC | 1.84e-36 | 3.40e+00 | 0.5341 |
200205 | IBA57 | HCC5 | Human | Liver | HCC | 2.13e-56 | 2.70e+00 | 0.4932 |
200205 | IBA57 | S015 | Human | Liver | HCC | 1.98e-03 | 1.57e-01 | 0.2375 |
200205 | IBA57 | S016 | Human | Liver | HCC | 1.78e-02 | 1.89e-01 | 0.2243 |
200205 | IBA57 | C04 | Human | Oral cavity | OSCC | 4.61e-09 | 4.14e-01 | 0.2633 |
200205 | IBA57 | C21 | Human | Oral cavity | OSCC | 5.54e-17 | 5.02e-01 | 0.2678 |
200205 | IBA57 | C30 | Human | Oral cavity | OSCC | 2.85e-15 | 6.52e-01 | 0.3055 |
200205 | IBA57 | C38 | Human | Oral cavity | OSCC | 9.34e-03 | 4.04e-01 | 0.172 |
200205 | IBA57 | C43 | Human | Oral cavity | OSCC | 2.00e-08 | 1.61e-01 | 0.1704 |
200205 | IBA57 | C46 | Human | Oral cavity | OSCC | 1.81e-08 | 2.48e-01 | 0.1673 |
200205 | IBA57 | C06 | Human | Oral cavity | OSCC | 1.28e-04 | 4.24e-01 | 0.2699 |
200205 | IBA57 | C08 | Human | Oral cavity | OSCC | 9.03e-10 | 1.87e-01 | 0.1919 |
200205 | IBA57 | C09 | Human | Oral cavity | OSCC | 2.94e-02 | 9.40e-02 | 0.1431 |
200205 | IBA57 | LN46 | Human | Oral cavity | OSCC | 1.40e-03 | 2.42e-01 | 0.1666 |
200205 | IBA57 | LP15 | Human | Oral cavity | LP | 1.16e-05 | 5.38e-01 | 0.2174 |
200205 | IBA57 | SYSMH2 | Human | Oral cavity | OSCC | 3.73e-03 | 1.40e-01 | 0.2326 |
200205 | IBA57 | SYSMH3 | Human | Oral cavity | OSCC | 8.35e-04 | 8.88e-02 | 0.2442 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000679021 | Liver | HCC | sulfur compound metabolic process | 212/7958 | 339/18723 | 5.60e-14 | 3.39e-12 | 212 |
GO:0042168 | Liver | HCC | heme metabolic process | 30/7958 | 42/18723 | 1.40e-04 | 1.13e-03 | 30 |
GO:00330131 | Liver | HCC | tetrapyrrole metabolic process | 39/7958 | 59/18723 | 2.14e-04 | 1.63e-03 | 39 |
GO:00067781 | Liver | HCC | porphyrin-containing compound metabolic process | 33/7958 | 49/18723 | 3.86e-04 | 2.62e-03 | 33 |
GO:0042440 | Liver | HCC | pigment metabolic process | 51/7958 | 84/18723 | 5.74e-04 | 3.65e-03 | 51 |
GO:0006783 | Liver | HCC | heme biosynthetic process | 19/7958 | 27/18723 | 3.18e-03 | 1.47e-02 | 19 |
GO:0006779 | Liver | HCC | porphyrin-containing compound biosynthetic process | 21/7958 | 31/18723 | 4.01e-03 | 1.76e-02 | 21 |
GO:0033014 | Liver | HCC | tetrapyrrole biosynthetic process | 21/7958 | 31/18723 | 4.01e-03 | 1.76e-02 | 21 |
GO:0046148 | Liver | HCC | pigment biosynthetic process | 37/7958 | 62/18723 | 4.73e-03 | 2.02e-02 | 37 |
GO:0016226 | Liver | HCC | iron-sulfur cluster assembly | 18/7958 | 26/18723 | 5.37e-03 | 2.24e-02 | 18 |
GO:0031163 | Liver | HCC | metallo-sulfur cluster assembly | 18/7958 | 26/18723 | 5.37e-03 | 2.24e-02 | 18 |
GO:00067905 | Oral cavity | OSCC | sulfur compound metabolic process | 168/7305 | 339/18723 | 4.50e-05 | 3.84e-04 | 168 |
GO:00162262 | Oral cavity | OSCC | iron-sulfur cluster assembly | 19/7305 | 26/18723 | 4.46e-04 | 2.70e-03 | 19 |
GO:00311632 | Oral cavity | OSCC | metallo-sulfur cluster assembly | 19/7305 | 26/18723 | 4.46e-04 | 2.70e-03 | 19 |
GO:00461481 | Oral cavity | OSCC | pigment biosynthetic process | 36/7305 | 62/18723 | 1.82e-03 | 8.57e-03 | 36 |
GO:00067831 | Oral cavity | OSCC | heme biosynthetic process | 17/7305 | 27/18723 | 1.01e-02 | 3.49e-02 | 17 |
GO:00162261 | Oral cavity | LP | iron-sulfur cluster assembly | 15/4623 | 26/18723 | 3.34e-04 | 3.34e-03 | 15 |
GO:00311631 | Oral cavity | LP | metallo-sulfur cluster assembly | 15/4623 | 26/18723 | 3.34e-04 | 3.34e-03 | 15 |
GO:000679012 | Oral cavity | LP | sulfur compound metabolic process | 106/4623 | 339/18723 | 3.36e-03 | 2.25e-02 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IBA57 | SNV | Missense_Mutation | rs755109511 | c.422C>T | p.Ala141Val | p.A141V | Q5T440 | protein_coding | tolerated(0.19) | benign(0.01) | TCGA-HU-A4GH-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
IBA57 | SNV | Missense_Mutation | novel | c.994C>G | p.His332Asp | p.H332D | Q5T440 | protein_coding | tolerated(0.15) | benign(0.348) | TCGA-VQ-A8PC-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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