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Gene: HSD11B1 |
Gene summary for HSD11B1 |
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Gene information | Species | Human | Gene symbol | HSD11B1 | Gene ID | 3290 |
Gene name | hydroxysteroid 11-beta dehydrogenase 1 | |
Gene Alias | 11-DH | |
Cytomap | 1q32.2 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | P28845 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3290 | HSD11B1 | NAFLD1 | Human | Liver | NAFLD | 5.59e-09 | 6.42e-01 | -0.04 |
3290 | HSD11B1 | S41 | Human | Liver | Cirrhotic | 1.85e-02 | 4.25e-01 | -0.0343 |
3290 | HSD11B1 | S43 | Human | Liver | Cirrhotic | 2.05e-04 | -6.15e-03 | -0.0187 |
3290 | HSD11B1 | S44 | Human | Liver | HCC | 4.03e-03 | 7.79e-01 | -0.0083 |
3290 | HSD11B1 | HCC1_Meng | Human | Liver | HCC | 1.07e-06 | -2.00e-01 | 0.0246 |
3290 | HSD11B1 | HCC2_Meng | Human | Liver | HCC | 1.12e-04 | -1.99e-01 | 0.0107 |
3290 | HSD11B1 | Pt13.a | Human | Liver | HCC | 2.58e-03 | -1.86e-01 | 0.021 |
3290 | HSD11B1 | Pt14.d | Human | Liver | HCC | 1.67e-02 | -1.84e-01 | 0.0143 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19013616 | Liver | NAFLD | organic cyclic compound catabolic process | 105/1882 | 495/18723 | 7.04e-14 | 5.15e-11 | 105 |
GO:00082023 | Liver | NAFLD | steroid metabolic process | 69/1882 | 319/18723 | 5.90e-10 | 1.28e-07 | 69 |
GO:00160426 | Liver | NAFLD | lipid catabolic process | 63/1882 | 320/18723 | 1.35e-07 | 1.02e-05 | 63 |
GO:190136111 | Liver | Cirrhotic | organic cyclic compound catabolic process | 213/4634 | 495/18723 | 1.58e-19 | 3.67e-17 | 213 |
GO:000820211 | Liver | Cirrhotic | steroid metabolic process | 143/4634 | 319/18723 | 2.79e-15 | 3.18e-13 | 143 |
GO:001604212 | Liver | Cirrhotic | lipid catabolic process | 112/4634 | 320/18723 | 2.31e-05 | 3.03e-04 | 112 |
GO:00303242 | Liver | Cirrhotic | lung development | 65/4634 | 177/18723 | 2.49e-04 | 2.25e-03 | 65 |
GO:00303232 | Liver | Cirrhotic | respiratory tube development | 66/4634 | 181/18723 | 2.82e-04 | 2.49e-03 | 66 |
GO:00605411 | Liver | Cirrhotic | respiratory system development | 67/4634 | 203/18723 | 4.81e-03 | 2.52e-02 | 67 |
GO:190136121 | Liver | HCC | organic cyclic compound catabolic process | 325/7958 | 495/18723 | 6.52e-26 | 2.18e-23 | 325 |
GO:00082022 | Liver | HCC | steroid metabolic process | 188/7958 | 319/18723 | 1.96e-09 | 5.63e-08 | 188 |
GO:001604221 | Liver | HCC | lipid catabolic process | 175/7958 | 320/18723 | 6.50e-06 | 7.88e-05 | 175 |
GO:003032311 | Liver | HCC | respiratory tube development | 95/7958 | 181/18723 | 4.15e-03 | 1.81e-02 | 95 |
GO:003032411 | Liver | HCC | lung development | 91/7958 | 177/18723 | 1.01e-02 | 3.80e-02 | 91 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSD11B1 | SNV | Missense_Mutation | novel | c.143N>T | p.Arg48Ile | p.R48I | P28845 | protein_coding | deleterious(0) | benign(0.142) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HSD11B1 | SNV | Missense_Mutation | rs145237704 | c.502N>A | p.Val168Ile | p.V168I | P28845 | protein_coding | tolerated(0.15) | benign(0.022) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HSD11B1 | insertion | Frame_Shift_Ins | novel | c.387dupT | p.His130SerfsTer2 | p.H130Sfs*2 | P28845 | protein_coding | TCGA-BS-A0V4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HSD11B1 | deletion | Frame_Shift_Del | novel | c.189delG | p.Thr64GlnfsTer33 | p.T64Qfs*33 | P28845 | protein_coding | TCGA-DD-AAVS-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
HSD11B1 | insertion | Frame_Shift_Ins | novel | c.171_172insGGAGCCCATGTGGT | p.Val63GlufsTer6 | p.V63Efs*6 | P28845 | protein_coding | TCGA-G3-AAV0-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
HSD11B1 | SNV | Missense_Mutation | rs200402963 | c.295N>C | p.Ala99Pro | p.A99P | P28845 | protein_coding | tolerated(0.58) | possibly_damaging(0.585) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
HSD11B1 | SNV | Missense_Mutation | rs374552497 | c.754N>T | p.Arg252Cys | p.R252C | P28845 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-44-A47A-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HSD11B1 | SNV | Missense_Mutation | c.133N>T | p.Gly45Trp | p.G45W | P28845 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-A491-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HSD11B1 | SNV | Missense_Mutation | novel | c.152N>G | p.Ala51Gly | p.A51G | P28845 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
HSD11B1 | SNV | Missense_Mutation | novel | c.143N>A | p.Arg48Lys | p.R48K | P28845 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-78-8640-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3290 | HSD11B1 | DRUGGABLE GENOME, ENZYME, SHORT CHAIN DEHYDROGENASE REDUCTASE | inhibitor | 381118868 | BMS-823778 | |
3290 | HSD11B1 | DRUGGABLE GENOME, ENZYME, SHORT CHAIN DEHYDROGENASE REDUCTASE | Flavanone | FLAVANONE | ||
3290 | HSD11B1 | DRUGGABLE GENOME, ENZYME, SHORT CHAIN DEHYDROGENASE REDUCTASE | BVT.2733 | |||
3290 | HSD11B1 | DRUGGABLE GENOME, ENZYME, SHORT CHAIN DEHYDROGENASE REDUCTASE | BMS-816336 | |||
3290 | HSD11B1 | DRUGGABLE GENOME, ENZYME, SHORT CHAIN DEHYDROGENASE REDUCTASE | HPP-851 | |||
3290 | HSD11B1 | DRUGGABLE GENOME, ENZYME, SHORT CHAIN DEHYDROGENASE REDUCTASE | inhibitor | 178103929 | ABT-384 | |
3290 | HSD11B1 | DRUGGABLE GENOME, ENZYME, SHORT CHAIN DEHYDROGENASE REDUCTASE | JTT-654 | |||
3290 | HSD11B1 | DRUGGABLE GENOME, ENZYME, SHORT CHAIN DEHYDROGENASE REDUCTASE | inhibitor | 223366028 | AZD-4017 | |
3290 | HSD11B1 | DRUGGABLE GENOME, ENZYME, SHORT CHAIN DEHYDROGENASE REDUCTASE | INCB13739 | |||
3290 | HSD11B1 | DRUGGABLE GENOME, ENZYME, SHORT CHAIN DEHYDROGENASE REDUCTASE | GLYCYRRHIZIN | GLYCYRRHIZIN |
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