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Gene: HOXB2 |
Gene summary for HOXB2 |
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Gene information | Species | Human | Gene symbol | HOXB2 | Gene ID | 3212 |
Gene name | homeobox B2 | |
Gene Alias | HOX2 | |
Cytomap | 17q21.32 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P14652 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3212 | HOXB2 | GSM4909286 | Human | Breast | IDC | 1.57e-03 | -1.21e-01 | 0.1081 |
3212 | HOXB2 | GSM4909287 | Human | Breast | IDC | 2.44e-02 | -1.22e-01 | 0.2057 |
3212 | HOXB2 | GSM4909293 | Human | Breast | IDC | 7.48e-03 | -1.12e-01 | 0.1581 |
3212 | HOXB2 | GSM4909297 | Human | Breast | IDC | 7.43e-04 | -1.18e-01 | 0.1517 |
3212 | HOXB2 | GSM4909298 | Human | Breast | IDC | 1.32e-02 | -1.11e-01 | 0.1551 |
3212 | HOXB2 | GSM4909306 | Human | Breast | IDC | 2.37e-02 | 2.09e-01 | 0.1564 |
3212 | HOXB2 | GSM4909307 | Human | Breast | IDC | 7.86e-09 | 3.81e-01 | 0.1569 |
3212 | HOXB2 | GSM4909308 | Human | Breast | IDC | 2.15e-48 | 8.24e-01 | 0.158 |
3212 | HOXB2 | GSM4909311 | Human | Breast | IDC | 2.02e-04 | -1.76e-02 | 0.1534 |
3212 | HOXB2 | GSM4909319 | Human | Breast | IDC | 2.41e-07 | -6.62e-03 | 0.1563 |
3212 | HOXB2 | M2 | Human | Breast | IDC | 9.49e-03 | 3.38e-01 | 0.21 |
3212 | HOXB2 | M5 | Human | Breast | IDC | 5.57e-08 | 6.85e-01 | 0.1598 |
3212 | HOXB2 | NCCBC14 | Human | Breast | DCIS | 2.08e-06 | 3.88e-01 | 0.2021 |
3212 | HOXB2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 9.84e-07 | 5.98e-01 | 0.0131 |
3212 | HOXB2 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.23e-03 | 4.88e-01 | 0.0171 |
3212 | HOXB2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 8.49e-13 | 4.71e-01 | 0.0588 |
3212 | HOXB2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.01e-03 | 6.70e-01 | 0.3487 |
3212 | HOXB2 | LZE4T | Human | Esophagus | ESCC | 8.16e-04 | -3.05e-02 | 0.0811 |
3212 | HOXB2 | LZE24T | Human | Esophagus | ESCC | 4.24e-39 | 1.25e+00 | 0.0596 |
3212 | HOXB2 | P1T-E | Human | Esophagus | ESCC | 7.93e-04 | 3.70e-01 | 0.0875 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004885713 | Breast | IDC | neural nucleus development | 21/1434 | 64/18723 | 5.35e-09 | 4.28e-07 | 21 |
GO:004885723 | Breast | DCIS | neural nucleus development | 20/1390 | 64/18723 | 1.87e-08 | 1.29e-06 | 20 |
GO:0048857 | Colorectum | AD | neural nucleus development | 27/3918 | 64/18723 | 9.57e-05 | 1.45e-03 | 27 |
GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
GO:00488571 | Colorectum | SER | neural nucleus development | 26/2897 | 64/18723 | 1.09e-06 | 5.11e-05 | 26 |
GO:00488573 | Colorectum | MSI-H | neural nucleus development | 13/1319 | 64/18723 | 4.43e-04 | 9.50e-03 | 13 |
GO:00020115 | Esophagus | ESCC | morphogenesis of an epithelial sheet | 42/8552 | 57/18723 | 1.62e-05 | 1.45e-04 | 42 |
GO:004885718 | Esophagus | ESCC | neural nucleus development | 44/8552 | 64/18723 | 1.59e-04 | 1.05e-03 | 44 |
GO:00485687 | Esophagus | ESCC | embryonic organ development | 228/8552 | 427/18723 | 7.28e-04 | 3.79e-03 | 228 |
GO:00487052 | Esophagus | ESCC | skeletal system morphogenesis | 120/8552 | 220/18723 | 4.90e-03 | 1.89e-02 | 120 |
GO:00020114 | Oral cavity | OSCC | morphogenesis of an epithelial sheet | 37/7305 | 57/18723 | 6.66e-05 | 5.38e-04 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HOXB2 | SNV | Missense_Mutation | novel | c.971N>A | p.Pro324His | p.P324H | P14652 | protein_coding | deleterious(0) | possibly_damaging(0.65) | TCGA-77-8144-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HOXB2 | deletion | Frame_Shift_Del | rs764013512 | c.272delC | p.Pro91ArgfsTer8 | p.P91Rfs*8 | P14652 | protein_coding | TCGA-85-8288-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
HOXB2 | SNV | Missense_Mutation | novel | c.104N>T | p.Ser35Leu | p.S35L | P14652 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CQ-6219-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
HOXB2 | SNV | Missense_Mutation | novel | c.364N>T | p.Pro122Ser | p.P122S | P14652 | protein_coding | tolerated(0.22) | benign(0.003) | TCGA-UF-A7J9-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HOXB2 | SNV | Missense_Mutation | novel | c.841N>T | p.Gly281Trp | p.G281W | P14652 | protein_coding | deleterious(0.05) | possibly_damaging(0.818) | TCGA-G9-6342-01 | Prostate | prostate adenocarcinoma | Male | <65 | 6 | Unknown | Unknown | SD |
HOXB2 | SNV | Missense_Mutation | novel | c.584N>A | p.Arg195His | p.R195H | P14652 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
HOXB2 | SNV | Missense_Mutation | c.986N>G | p.Ser329Cys | p.S329C | P14652 | protein_coding | deleterious(0.05) | possibly_damaging(0.817) | TCGA-HU-A4GH-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HOXB2 | SNV | Missense_Mutation | rs765776487 | c.532G>A | p.Ala178Thr | p.A178T | P14652 | protein_coding | deleterious(0) | possibly_damaging(0.67) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD |
HOXB2 | SNV | Missense_Mutation | novel | c.927N>A | p.Phe309Leu | p.F309L | P14652 | protein_coding | tolerated(0.52) | benign(0.005) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
HOXB2 | deletion | Frame_Shift_Del | rs764013512 | c.272delN | p.Pro91ArgfsTer8 | p.P91Rfs*8 | P14652 | protein_coding | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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