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Gene: HOOK2 |
Gene summary for HOOK2 |
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Gene information | Species | Human | Gene symbol | HOOK2 | Gene ID | 29911 |
Gene name | hook microtubule tethering protein 2 | |
Gene Alias | HK2 | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q96ED9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29911 | HOOK2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.37e-03 | 1.54e-01 | 0.0155 |
29911 | HOOK2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.15e-07 | 7.29e-01 | -0.1808 |
29911 | HOOK2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.71e-09 | 6.50e-01 | -0.0811 |
29911 | HOOK2 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.25e-04 | 5.02e-01 | -0.1088 |
29911 | HOOK2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.09e-23 | 7.45e-01 | -0.1954 |
29911 | HOOK2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.81e-04 | 4.71e-01 | -0.1207 |
29911 | HOOK2 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.86e-08 | 6.78e-01 | -0.1526 |
29911 | HOOK2 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.59e-15 | 7.30e-01 | -0.1464 |
29911 | HOOK2 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.67e-10 | 5.50e-01 | -0.1001 |
29911 | HOOK2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.01e-15 | 8.74e-01 | -0.059 |
29911 | HOOK2 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.04e-03 | 5.97e-01 | -0.0842 |
29911 | HOOK2 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.88e-20 | 7.05e-01 | 0.096 |
29911 | HOOK2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.57e-02 | 6.36e-01 | 0.0446 |
29911 | HOOK2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.72e-04 | 6.76e-01 | 0.0528 |
29911 | HOOK2 | HTA11_10623_2000001011 | Human | Colorectum | AD | 6.75e-03 | 5.69e-01 | -0.0177 |
29911 | HOOK2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.35e-11 | 7.24e-01 | 0.0338 |
29911 | HOOK2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.55e-26 | 9.64e-01 | 0.0674 |
29911 | HOOK2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 4.93e-06 | 7.08e-01 | 0.0112 |
29911 | HOOK2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 8.64e-09 | 6.81e-01 | 0.0588 |
29911 | HOOK2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.24e-18 | 9.62e-01 | 0.294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016482 | Colorectum | AD | cytosolic transport | 68/3918 | 168/18723 | 6.00e-09 | 3.72e-07 | 68 |
GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
GO:0007034 | Colorectum | AD | vacuolar transport | 60/3918 | 157/18723 | 4.97e-07 | 1.85e-05 | 60 |
GO:0007032 | Colorectum | AD | endosome organization | 33/3918 | 82/18723 | 5.30e-05 | 9.01e-04 | 33 |
GO:0007041 | Colorectum | AD | lysosomal transport | 42/3918 | 114/18723 | 6.61e-05 | 1.07e-03 | 42 |
GO:0098927 | Colorectum | AD | vesicle-mediated transport between endosomal compartments | 19/3918 | 43/18723 | 5.03e-04 | 5.43e-03 | 19 |
GO:0030705 | Colorectum | AD | cytoskeleton-dependent intracellular transport | 60/3918 | 195/18723 | 7.56e-04 | 7.59e-03 | 60 |
GO:0045022 | Colorectum | AD | early endosome to late endosome transport | 17/3918 | 40/18723 | 1.66e-03 | 1.38e-02 | 17 |
GO:0007033 | Colorectum | AD | vacuole organization | 53/3918 | 180/18723 | 4.18e-03 | 2.89e-02 | 53 |
GO:00164821 | Colorectum | SER | cytosolic transport | 46/2897 | 168/18723 | 5.20e-05 | 1.25e-03 | 46 |
GO:00070341 | Colorectum | SER | vacuolar transport | 43/2897 | 157/18723 | 8.92e-05 | 1.93e-03 | 43 |
GO:00160501 | Colorectum | SER | vesicle organization | 69/2897 | 300/18723 | 3.59e-04 | 5.61e-03 | 69 |
GO:00989271 | Colorectum | SER | vesicle-mediated transport between endosomal compartments | 16/2897 | 43/18723 | 4.18e-04 | 6.17e-03 | 16 |
GO:00070321 | Colorectum | SER | endosome organization | 24/2897 | 82/18723 | 1.11e-03 | 1.28e-02 | 24 |
GO:00450221 | Colorectum | SER | early endosome to late endosome transport | 14/2897 | 40/18723 | 1.88e-03 | 1.90e-02 | 14 |
GO:00307051 | Colorectum | SER | cytoskeleton-dependent intracellular transport | 44/2897 | 195/18723 | 5.53e-03 | 4.09e-02 | 44 |
GO:00160502 | Colorectum | MSS | vesicle organization | 93/3467 | 300/18723 | 1.04e-07 | 4.97e-06 | 93 |
GO:00164822 | Colorectum | MSS | cytosolic transport | 59/3467 | 168/18723 | 2.29e-07 | 9.79e-06 | 59 |
GO:00070342 | Colorectum | MSS | vacuolar transport | 52/3467 | 157/18723 | 8.25e-06 | 2.07e-04 | 52 |
GO:00070411 | Colorectum | MSS | lysosomal transport | 36/3467 | 114/18723 | 5.38e-04 | 6.04e-03 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HOOK2 | SNV | Missense_Mutation | novel | c.1357C>A | p.Leu453Met | p.L453M | Q96ED9 | protein_coding | tolerated(0.42) | benign(0.123) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
HOOK2 | SNV | Missense_Mutation | rs751517458 | c.1865C>T | p.Ala622Val | p.A622V | Q96ED9 | protein_coding | tolerated(0.22) | benign(0.003) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
HOOK2 | SNV | Missense_Mutation | novel | c.753N>T | p.Glu251Asp | p.E251D | Q96ED9 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
HOOK2 | SNV | Missense_Mutation | novel | c.1996N>A | p.Ala666Thr | p.A666T | Q96ED9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
HOOK2 | SNV | Missense_Mutation | rs148596780 | c.793N>T | p.Arg265Cys | p.R265C | Q96ED9 | protein_coding | deleterious(0) | possibly_damaging(0.786) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HOOK2 | SNV | Missense_Mutation | c.1348N>A | p.Ala450Thr | p.A450T | Q96ED9 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HOOK2 | SNV | Missense_Mutation | c.315C>A | p.Phe105Leu | p.F105L | Q96ED9 | protein_coding | tolerated(0.53) | benign(0.011) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HOOK2 | SNV | Missense_Mutation | rs756706415 | c.1270N>A | p.Ala424Thr | p.A424T | Q96ED9 | protein_coding | tolerated(0.42) | benign(0.028) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HOOK2 | SNV | Missense_Mutation | c.1948N>C | p.Glu650Gln | p.E650Q | Q96ED9 | protein_coding | deleterious(0.03) | possibly_damaging(0.809) | TCGA-D1-A16J-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
HOOK2 | SNV | Missense_Mutation | rs201380756 | c.2141N>A | p.Arg714His | p.R714H | Q96ED9 | protein_coding | tolerated_low_confidence(0.07) | probably_damaging(0.947) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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