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Gene: HNRNPUL2 |
Gene summary for HNRNPUL2 |
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Gene information | Species | Human | Gene symbol | HNRNPUL2 | Gene ID | 221092 |
Gene name | heterogeneous nuclear ribonucleoprotein U like 2 | |
Gene Alias | HNRPUL2 | |
Cytomap | 11q12.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q1KMD3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221092 | HNRNPUL2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.81e-06 | 1.64e-01 | 0.0155 |
221092 | HNRNPUL2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.70e-09 | 2.66e-01 | -0.1808 |
221092 | HNRNPUL2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.92e-17 | 4.41e-01 | -0.0811 |
221092 | HNRNPUL2 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.17e-12 | 2.98e-01 | -0.1088 |
221092 | HNRNPUL2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.06e-36 | 5.88e-01 | -0.1954 |
221092 | HNRNPUL2 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.20e-07 | 5.05e-01 | -0.2602 |
221092 | HNRNPUL2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.88e-11 | 6.10e-01 | -0.2196 |
221092 | HNRNPUL2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.49e-10 | 3.09e-01 | -0.1207 |
221092 | HNRNPUL2 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.74e-08 | 2.71e-01 | -0.1526 |
221092 | HNRNPUL2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.63e-22 | 4.18e-01 | -0.1464 |
221092 | HNRNPUL2 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.35e-15 | 2.67e-01 | -0.1001 |
221092 | HNRNPUL2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.12e-21 | 5.14e-01 | -0.059 |
221092 | HNRNPUL2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.14e-07 | 3.56e-01 | -0.1706 |
221092 | HNRNPUL2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.49e-08 | 4.15e-01 | -0.1462 |
221092 | HNRNPUL2 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.65e-04 | 1.84e-01 | -0.0842 |
221092 | HNRNPUL2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.12e-06 | 3.05e-01 | -0.0179 |
221092 | HNRNPUL2 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.09e-17 | 3.70e-01 | 0.096 |
221092 | HNRNPUL2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.84e-10 | 4.66e-01 | 0.0446 |
221092 | HNRNPUL2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 7.79e-04 | 4.04e-01 | 0.0451 |
221092 | HNRNPUL2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.19e-02 | 1.83e-01 | 0.0528 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HNRNPUL2 | SNV | Missense_Mutation | c.1088G>T | p.Cys363Phe | p.C363F | Q1KMD3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-44-6774-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | alimta | SD | |
HNRNPUL2 | SNV | Missense_Mutation | c.1529T>A | p.Leu510His | p.L510H | Q1KMD3 | protein_coding | deleterious(0) | possibly_damaging(0.754) | TCGA-50-6593-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
HNRNPUL2 | SNV | Missense_Mutation | rs780214569 | c.677C>T | p.Ser226Leu | p.S226L | Q1KMD3 | protein_coding | deleterious(0.02) | benign(0.444) | TCGA-55-A48Y-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR |
HNRNPUL2 | SNV | Missense_Mutation | novel | c.1357N>A | p.Glu453Lys | p.E453K | Q1KMD3 | protein_coding | deleterious(0) | possibly_damaging(0.814) | TCGA-MP-A4TI-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
HNRNPUL2 | SNV | Missense_Mutation | c.1059N>C | p.Gln353His | p.Q353H | Q1KMD3 | protein_coding | deleterious(0) | benign(0.429) | TCGA-18-3417-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
HNRNPUL2 | SNV | Missense_Mutation | novel | c.1267N>T | p.Pro423Ser | p.P423S | Q1KMD3 | protein_coding | tolerated(0.18) | benign(0.444) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
HNRNPUL2 | SNV | Missense_Mutation | c.1987N>T | p.Gly663Trp | p.G663W | Q1KMD3 | protein_coding | tolerated(0.06) | probably_damaging(0.998) | TCGA-39-5019-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HNRNPUL2 | SNV | Missense_Mutation | rs766630079 | c.311G>T | p.Gly104Val | p.G104V | Q1KMD3 | protein_coding | tolerated(0.06) | benign(0.001) | TCGA-63-A5MS-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HNRNPUL2 | SNV | Missense_Mutation | novel | c.595G>T | p.Gly199Trp | p.G199W | Q1KMD3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-L3-A4E7-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HNRNPUL2 | SNV | Missense_Mutation | novel | c.1117N>C | p.Glu373Gln | p.E373Q | Q1KMD3 | protein_coding | deleterious(0.01) | possibly_damaging(0.903) | TCGA-CQ-7071-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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