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Gene: HM13 |
Gene summary for HM13 |
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Gene information | Species | Human | Gene symbol | HM13 | Gene ID | 81502 |
Gene name | histocompatibility minor 13 | |
Gene Alias | H13 | |
Cytomap | 20q11.21 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | A0A0S2Z5V7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81502 | HM13 | CA_HPV_1 | Human | Cervix | CC | 6.82e-03 | 4.81e-03 | 0.0264 |
81502 | HM13 | N_HPV_1 | Human | Cervix | N_HPV | 6.05e-03 | -1.26e-01 | 0.0079 |
81502 | HM13 | N_HPV_2 | Human | Cervix | N_HPV | 4.43e-02 | 1.23e-01 | -0.0131 |
81502 | HM13 | Tumor | Human | Cervix | CC | 1.24e-10 | 4.55e-01 | 0.1241 |
81502 | HM13 | sample3 | Human | Cervix | CC | 4.45e-27 | 5.27e-01 | 0.1387 |
81502 | HM13 | T3 | Human | Cervix | CC | 8.24e-19 | 5.31e-01 | 0.1389 |
81502 | HM13 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.22e-07 | 5.95e-01 | -0.1808 |
81502 | HM13 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.75e-02 | 4.44e-01 | -0.0811 |
81502 | HM13 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.33e-10 | 4.14e-01 | -0.1954 |
81502 | HM13 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.10e-04 | 8.80e-01 | -0.2602 |
81502 | HM13 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.78e-03 | 7.83e-01 | -0.2196 |
81502 | HM13 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.00e-03 | 4.74e-01 | -0.1526 |
81502 | HM13 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.74e-14 | 6.72e-01 | -0.1464 |
81502 | HM13 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.92e-03 | 3.53e-01 | -0.1001 |
81502 | HM13 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.55e-19 | 9.76e-01 | -0.059 |
81502 | HM13 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.37e-11 | 5.45e-01 | 0.096 |
81502 | HM13 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.14e-06 | 4.80e-01 | 0.0338 |
81502 | HM13 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.29e-09 | 5.51e-01 | 0.0674 |
81502 | HM13 | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.48e-03 | 3.96e-01 | 0.0588 |
81502 | HM13 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.61e-04 | 3.57e-01 | 0.294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:003497610 | Cervix | CC | response to endoplasmic reticulum stress | 57/2311 | 256/18723 | 5.81e-06 | 1.42e-04 | 57 |
GO:00017018 | Cervix | CC | in utero embryonic development | 71/2311 | 367/18723 | 7.21e-05 | 1.00e-03 | 71 |
GO:00064657 | Cervix | CC | signal peptide processing | 8/2311 | 14/18723 | 8.01e-05 | 1.09e-03 | 8 |
GO:00516048 | Cervix | CC | protein maturation | 56/2311 | 294/18723 | 5.90e-04 | 5.59e-03 | 56 |
GO:003497623 | Cervix | N_HPV | response to endoplasmic reticulum stress | 20/534 | 256/18723 | 4.88e-05 | 1.13e-03 | 20 |
GO:005160414 | Cervix | N_HPV | protein maturation | 20/534 | 294/18723 | 3.17e-04 | 4.75e-03 | 20 |
GO:001049815 | Cervix | N_HPV | proteasomal protein catabolic process | 27/534 | 490/18723 | 9.06e-04 | 1.08e-02 | 27 |
GO:00164854 | Cervix | N_HPV | protein processing | 15/534 | 225/18723 | 2.09e-03 | 2.00e-02 | 15 |
GO:000646511 | Cervix | N_HPV | signal peptide processing | 3/534 | 14/18723 | 6.64e-03 | 4.45e-02 | 3 |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0034976 | Colorectum | AD | response to endoplasmic reticulum stress | 90/3918 | 256/18723 | 8.48e-08 | 4.28e-06 | 90 |
GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
GO:0006465 | Colorectum | AD | signal peptide processing | 10/3918 | 14/18723 | 6.90e-05 | 1.11e-03 | 10 |
GO:0051604 | Colorectum | AD | protein maturation | 85/3918 | 294/18723 | 6.73e-04 | 6.91e-03 | 85 |
GO:0033619 | Colorectum | AD | membrane protein proteolysis | 21/3918 | 57/18723 | 4.16e-03 | 2.88e-02 | 21 |
GO:0036503 | Colorectum | AD | ERAD pathway | 34/3918 | 107/18723 | 5.57e-03 | 3.63e-02 | 34 |
GO:0016485 | Colorectum | AD | protein processing | 63/3918 | 225/18723 | 6.77e-03 | 4.19e-02 | 63 |
GO:00104981 | Colorectum | SER | proteasomal protein catabolic process | 132/2897 | 490/18723 | 3.08e-11 | 5.55e-09 | 132 |
GO:00349761 | Colorectum | SER | response to endoplasmic reticulum stress | 74/2897 | 256/18723 | 3.01e-08 | 2.05e-06 | 74 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HM13 | SNV | Missense_Mutation | novel | c.1064N>G | p.His355Arg | p.H355R | Q8TCT9 | protein_coding | tolerated(0.19) | benign(0.048) | TCGA-CG-4465-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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