Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/HLTF_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/HLTF_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/HLTF_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/HLTF_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/HLTF_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
HLTF | BAS | Endometrium | Healthy | SREBF1,EZH2,DDX58, etc. | 2.54e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Endometrium/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
HLTF | MAST | Oral cavity | ADJ | EXD3,NKAPD1,TMEM220, etc. | 6.47e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/OralCavity/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
HLTF | NK | Oral cavity | Healthy | EXD3,NKAPD1,TMEM220, etc. | 1.97e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/OralCavity/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
HLTF | MAST | Oral cavity | Healthy | EXD3,NKAPD1,TMEM220, etc. | 2.13e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/OralCavity/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
HLTF | MAST | Oral cavity | LP | EXD3,NKAPD1,TMEM220, etc. | 1.65e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/OralCavity/Str/TF_LP/regulons_activity_in_dotplot.png) |
HLTF | CD8TEXP | Oral cavity | LP | EXD3,NKAPD1,TMEM220, etc. | 3.71e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/OralCavity/Str/TF_LP/regulons_activity_in_dotplot.png) |
HLTF | MAST | Oral cavity | OSCC | EXD3,NKAPD1,TMEM220, etc. | 2.23e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/OralCavity/Str/TF_OSCC/regulons_activity_in_dotplot.png) |
HLTF | SMC | Pancreas | ADJ | CEP76,BTBD3,CC2D2B, etc. | 2.49e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Pancreas/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
HLTF | PSC | Pancreas | ADJ | CEP76,BTBD3,CC2D2B, etc. | 1.25e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Pancreas/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
HLTF | FIB | Pancreas | PDAC | CEP76,BTBD3,CC2D2B, etc. | 3.13e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Pancreas/Str/TF_PDAC/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HLTF | SNV | Missense_Mutation | novel | c.830N>T | p.Asn277Ile | p.N277I | Q14527 | protein_coding | deleterious(0.04) | probably_damaging(0.98) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HLTF | SNV | Missense_Mutation | novel | c.1694C>T | p.Pro565Leu | p.P565L | Q14527 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HLTF | SNV | Missense_Mutation | novel | c.1505N>C | p.Val502Ala | p.V502A | Q14527 | protein_coding | deleterious(0.01) | probably_damaging(0.965) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
HLTF | SNV | Missense_Mutation | rs527812739 | c.800N>A | p.Arg267Gln | p.R267Q | Q14527 | protein_coding | deleterious(0.04) | possibly_damaging(0.678) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
HLTF | SNV | Missense_Mutation | novel | c.2506N>G | p.Asn836Asp | p.N836D | Q14527 | protein_coding | tolerated(0.5) | benign(0.014) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HLTF | SNV | Missense_Mutation | | c.2517N>A | p.Met839Ile | p.M839I | Q14527 | protein_coding | deleterious(0.02) | benign(0.23) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HLTF | SNV | Missense_Mutation | rs535340588 | c.1069N>A | p.Ala357Thr | p.A357T | Q14527 | protein_coding | tolerated(0.52) | benign(0.015) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HLTF | SNV | Missense_Mutation | | c.2407G>T | p.Asp803Tyr | p.D803Y | Q14527 | protein_coding | deleterious(0) | benign(0.417) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HLTF | SNV | Missense_Mutation | | c.286A>C | p.Asn96His | p.N96H | Q14527 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HLTF | SNV | Missense_Mutation | | c.1278N>T | p.Arg426Ser | p.R426S | Q14527 | protein_coding | tolerated(0.43) | benign(0.015) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |