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Gene: HIST1H2BD |
Gene summary for HIST1H2BD |
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Gene information | Species | Human | Gene symbol | HIST1H2BD | Gene ID | 3017 |
Gene name | H2B clustered histone 5 | |
Gene Alias | H2B.1B | |
Cytomap | 6p22.2 | |
Gene Type | protein-coding | GO ID | GO:0006323 | UniProtAcc | A0A024QZZ7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3017 | HIST1H2BD | CCI_2 | Human | Cervix | CC | 2.31e-23 | 1.30e+00 | 0.5249 |
3017 | HIST1H2BD | CCI_3 | Human | Cervix | CC | 2.36e-07 | 3.25e-01 | 0.516 |
3017 | HIST1H2BD | Tumor | Human | Cervix | CC | 9.07e-08 | 1.66e-01 | 0.1241 |
3017 | HIST1H2BD | sample1 | Human | Cervix | CC | 1.17e-02 | 1.58e-01 | 0.0959 |
3017 | HIST1H2BD | sample3 | Human | Cervix | CC | 9.07e-08 | 1.70e-01 | 0.1387 |
3017 | HIST1H2BD | H2 | Human | Cervix | HSIL_HPV | 4.15e-09 | 1.98e-01 | 0.0632 |
3017 | HIST1H2BD | T1 | Human | Cervix | CC | 6.85e-08 | 2.45e-01 | 0.0918 |
3017 | HIST1H2BD | T3 | Human | Cervix | CC | 3.83e-04 | 1.47e-01 | 0.1389 |
3017 | HIST1H2BD | HCC1_Meng | Human | Liver | HCC | 4.69e-43 | 8.30e-02 | 0.0246 |
3017 | HIST1H2BD | cirrhotic2 | Human | Liver | Cirrhotic | 2.36e-02 | 7.49e-02 | 0.0201 |
3017 | HIST1H2BD | HCC1 | Human | Liver | HCC | 1.01e-07 | 3.67e+00 | 0.5336 |
3017 | HIST1H2BD | Pt14.b | Human | Liver | HCC | 9.06e-06 | 3.11e-01 | 0.018 |
3017 | HIST1H2BD | S014 | Human | Liver | HCC | 1.13e-08 | 4.42e-01 | 0.2254 |
3017 | HIST1H2BD | S015 | Human | Liver | HCC | 3.24e-03 | 2.62e-01 | 0.2375 |
3017 | HIST1H2BD | S016 | Human | Liver | HCC | 1.21e-13 | 4.45e-01 | 0.2243 |
3017 | HIST1H2BD | S027 | Human | Liver | HCC | 1.28e-06 | 7.58e-01 | 0.2446 |
3017 | HIST1H2BD | S028 | Human | Liver | HCC | 5.38e-20 | 8.48e-01 | 0.2503 |
3017 | HIST1H2BD | S029 | Human | Liver | HCC | 3.92e-12 | 7.70e-01 | 0.2581 |
3017 | HIST1H2BD | RNA-P17T-P17T-2 | Human | Lung | IAC | 3.47e-03 | 7.96e-01 | 0.3371 |
3017 | HIST1H2BD | RNA-P17T-P17T-4 | Human | Lung | IAC | 2.10e-03 | 7.98e-01 | 0.343 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIST1H2BD | SNV | Missense_Mutation | novel | c.205N>C | p.Asp69His | p.D69H | P58876 | protein_coding | deleterious_low_confidence(0.01) | benign(0.267) | TCGA-MT-A51W-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIST1H2BD | SNV | Missense_Mutation | c.356T>A | p.Val119Asp | p.V119D | P58876 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.615) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
HIST1H2BD | SNV | Missense_Mutation | c.109N>T | p.Ser37Cys | p.S37C | P58876 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.834) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
HIST1H2BD | SNV | Missense_Mutation | c.365N>G | p.Tyr122Cys | p.Y122C | P58876 | protein_coding | deleterious_low_confidence(0.01) | benign(0.01) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
HIST1H2BD | SNV | Missense_Mutation | novel | c.125N>C | p.Val42Ala | p.V42A | P58876 | protein_coding | deleterious_low_confidence(0) | benign(0.315) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
HIST1H2BD | SNV | Missense_Mutation | novel | c.313G>T | p.Gly105Trp | p.G105W | P58876 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.995) | TCGA-VQ-A925-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
HIST1H2BD | insertion | Frame_Shift_Ins | novel | c.142_143insGTGACCCAAGAACCTTAAATAACAGAAG | p.Gln48ArgfsTer105 | p.Q48Rfs*105 | P58876 | protein_coding | TCGA-BR-A4QI-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | PD | ||
HIST1H2BD | SNV | Missense_Mutation | novel | c.274T>C | p.Ser92Pro | p.S92P | P58876 | protein_coding | deleterious_low_confidence(0.01) | benign(0.073) | TCGA-EM-A1CT-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HIST1H2BD | insertion | Frame_Shift_Ins | novel | c.370_371insCTGAATA | p.Ser124ThrfsTer3 | p.S124Tfs*3 | P58876 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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