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Gene: HIC2 |
Gene summary for HIC2 |
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Gene information | Species | Human | Gene symbol | HIC2 | Gene ID | 23119 |
Gene name | HIC ZBTB transcriptional repressor 2 | |
Gene Alias | HRG22 | |
Cytomap | 22q11.21 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q96JB3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23119 | HIC2 | LZE7T | Human | Esophagus | ESCC | 2.48e-05 | 3.58e-01 | 0.0667 |
23119 | HIC2 | LZE24T | Human | Esophagus | ESCC | 3.07e-05 | 1.08e-01 | 0.0596 |
23119 | HIC2 | P1T-E | Human | Esophagus | ESCC | 3.06e-03 | 3.24e-01 | 0.0875 |
23119 | HIC2 | P2T-E | Human | Esophagus | ESCC | 2.65e-17 | 1.04e-01 | 0.1177 |
23119 | HIC2 | P4T-E | Human | Esophagus | ESCC | 4.00e-12 | 2.98e-01 | 0.1323 |
23119 | HIC2 | P5T-E | Human | Esophagus | ESCC | 4.12e-02 | 5.54e-02 | 0.1327 |
23119 | HIC2 | P8T-E | Human | Esophagus | ESCC | 5.47e-04 | 6.91e-02 | 0.0889 |
23119 | HIC2 | P9T-E | Human | Esophagus | ESCC | 4.72e-04 | 1.93e-01 | 0.1131 |
23119 | HIC2 | P10T-E | Human | Esophagus | ESCC | 5.48e-11 | 2.16e-01 | 0.116 |
23119 | HIC2 | P11T-E | Human | Esophagus | ESCC | 4.31e-03 | 2.10e-01 | 0.1426 |
23119 | HIC2 | P12T-E | Human | Esophagus | ESCC | 7.38e-10 | 2.32e-01 | 0.1122 |
23119 | HIC2 | P15T-E | Human | Esophagus | ESCC | 1.65e-03 | 6.95e-02 | 0.1149 |
23119 | HIC2 | P16T-E | Human | Esophagus | ESCC | 6.25e-10 | 1.40e-01 | 0.1153 |
23119 | HIC2 | P21T-E | Human | Esophagus | ESCC | 2.05e-09 | 3.53e-01 | 0.1617 |
23119 | HIC2 | P22T-E | Human | Esophagus | ESCC | 3.76e-04 | 8.21e-02 | 0.1236 |
23119 | HIC2 | P23T-E | Human | Esophagus | ESCC | 2.08e-06 | 2.35e-01 | 0.108 |
23119 | HIC2 | P24T-E | Human | Esophagus | ESCC | 3.97e-05 | 5.76e-02 | 0.1287 |
23119 | HIC2 | P26T-E | Human | Esophagus | ESCC | 4.75e-24 | 3.66e-01 | 0.1276 |
23119 | HIC2 | P27T-E | Human | Esophagus | ESCC | 7.79e-08 | 1.99e-01 | 0.1055 |
23119 | HIC2 | P28T-E | Human | Esophagus | ESCC | 1.79e-23 | 6.08e-01 | 0.1149 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIC2 | SNV | Missense_Mutation | c.1327G>T | p.Val443Leu | p.V443L | Q96JB3 | protein_coding | deleterious(0.01) | possibly_damaging(0.82) | TCGA-D1-A16J-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
HIC2 | SNV | Missense_Mutation | novel | c.1541N>G | p.Tyr514Cys | p.Y514C | Q96JB3 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIC2 | SNV | Missense_Mutation | novel | c.1627N>G | p.Thr543Ala | p.T543A | Q96JB3 | protein_coding | deleterious(0.01) | benign(0.234) | TCGA-EC-A1QX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamide | PD |
HIC2 | SNV | Missense_Mutation | novel | c.26N>A | p.Arg9Gln | p.R9Q | Q96JB3 | protein_coding | tolerated_low_confidence(0.13) | possibly_damaging(0.733) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIC2 | SNV | Missense_Mutation | c.1825N>T | p.Arg609Cys | p.R609C | Q96JB3 | protein_coding | deleterious(0) | probably_damaging(0.92) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HIC2 | SNV | Missense_Mutation | novel | c.203N>A | p.Ser68Asn | p.S68N | Q96JB3 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EY-A1GU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIC2 | SNV | Missense_Mutation | c.1209N>T | p.Lys403Asn | p.K403N | Q96JB3 | protein_coding | tolerated(0.06) | benign(0.397) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HIC2 | SNV | Missense_Mutation | rs367902699 | c.187N>A | p.Val63Ile | p.V63I | Q96JB3 | protein_coding | tolerated(1) | benign(0.068) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
HIC2 | SNV | Missense_Mutation | novel | c.1213N>A | p.Ala405Thr | p.A405T | Q96JB3 | protein_coding | tolerated(0.5) | benign(0) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
HIC2 | SNV | Missense_Mutation | novel | c.1633N>T | p.Arg545Cys | p.R545C | Q96JB3 | protein_coding | deleterious(0.01) | possibly_damaging(0.719) | TCGA-SJ-A6ZI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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