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Gene: HEPACAM2 |
Gene summary for HEPACAM2 |
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Gene information | Species | Human | Gene symbol | HEPACAM2 | Gene ID | 253012 |
Gene name | HEPACAM family member 2 | |
Gene Alias | MIKI | |
Cytomap | 7q21.2 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | A8MVW5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
253012 | HEPACAM2 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.14e-17 | 1.25e+00 | -0.1088 |
253012 | HEPACAM2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.31e-03 | 4.32e-01 | -0.1207 |
253012 | HEPACAM2 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.09e-06 | 3.52e-01 | -0.1464 |
253012 | HEPACAM2 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.32e-06 | 3.75e-01 | -0.1001 |
253012 | HEPACAM2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.69e-04 | 6.45e-01 | 0.3487 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HEPACAM2 | SNV | Missense_Mutation | c.1355N>A | p.Arg452Lys | p.R452K | A8MVW5 | protein_coding | tolerated(0.18) | benign(0.007) | TCGA-BG-A0LW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HEPACAM2 | SNV | Missense_Mutation | c.1174N>A | p.Leu392Ile | p.L392I | A8MVW5 | protein_coding | deleterious(0.02) | benign(0.341) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HEPACAM2 | SNV | Missense_Mutation | rs267601638 | c.1321N>T | p.Pro441Ser | p.P441S | A8MVW5 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HEPACAM2 | SNV | Missense_Mutation | c.1000A>C | p.Met334Leu | p.M334L | A8MVW5 | protein_coding | tolerated(0.32) | benign(0) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HEPACAM2 | SNV | Missense_Mutation | novel | c.933N>G | p.Asn311Lys | p.N311K | A8MVW5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HEPACAM2 | SNV | Missense_Mutation | novel | c.1228G>T | p.Gly410Cys | p.G410C | A8MVW5 | protein_coding | deleterious(0.03) | benign(0.161) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HEPACAM2 | SNV | Missense_Mutation | novel | c.1403N>G | p.Thr468Arg | p.T468R | A8MVW5 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-EY-A3QX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD |
HEPACAM2 | SNV | Missense_Mutation | rs142784565 | c.226G>A | p.Val76Ile | p.V76I | A8MVW5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HEPACAM2 | SNV | Missense_Mutation | novel | c.428A>C | p.Tyr143Ser | p.Y143S | A8MVW5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
HEPACAM2 | SNV | Missense_Mutation | novel | c.298N>T | p.Pro100Ser | p.P100S | A8MVW5 | protein_coding | tolerated(0.28) | possibly_damaging(0.572) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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