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Gene: HAUS6 |
Gene summary for HAUS6 |
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Gene information | Species | Human | Gene symbol | HAUS6 | Gene ID | 54801 |
Gene name | HAUS augmin like complex subunit 6 | |
Gene Alias | Dgt6 | |
Cytomap | 9p22.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q7Z4H7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54801 | HAUS6 | C04 | Human | Oral cavity | OSCC | 5.06e-04 | 3.45e-01 | 0.2633 |
54801 | HAUS6 | C21 | Human | Oral cavity | OSCC | 9.56e-04 | 2.05e-01 | 0.2678 |
54801 | HAUS6 | C30 | Human | Oral cavity | OSCC | 5.98e-17 | 7.90e-01 | 0.3055 |
54801 | HAUS6 | C38 | Human | Oral cavity | OSCC | 7.45e-04 | 5.17e-01 | 0.172 |
54801 | HAUS6 | C43 | Human | Oral cavity | OSCC | 6.16e-19 | 3.33e-01 | 0.1704 |
54801 | HAUS6 | C46 | Human | Oral cavity | OSCC | 1.82e-05 | 2.10e-01 | 0.1673 |
54801 | HAUS6 | C51 | Human | Oral cavity | OSCC | 5.91e-04 | 3.64e-01 | 0.2674 |
54801 | HAUS6 | SYSMH1 | Human | Oral cavity | OSCC | 1.22e-04 | 1.43e-01 | 0.1127 |
54801 | HAUS6 | SYSMH2 | Human | Oral cavity | OSCC | 1.96e-12 | 3.28e-01 | 0.2326 |
54801 | HAUS6 | SYSMH3 | Human | Oral cavity | OSCC | 3.96e-20 | 5.33e-01 | 0.2442 |
54801 | HAUS6 | SYSMH6 | Human | Oral cavity | OSCC | 5.11e-05 | 2.38e-01 | 0.1275 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070517 | Oral cavity | OSCC | spindle organization | 117/7305 | 184/18723 | 1.16e-11 | 4.17e-10 | 117 |
GO:00512255 | Oral cavity | OSCC | spindle assembly | 73/7305 | 117/18723 | 2.51e-07 | 3.96e-06 | 73 |
GO:00070981 | Oral cavity | OSCC | centrosome cycle | 66/7305 | 130/18723 | 4.17e-03 | 1.70e-02 | 66 |
GO:00310232 | Oral cavity | OSCC | microtubule organizing center organization | 70/7305 | 143/18723 | 9.71e-03 | 3.44e-02 | 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HAUS6 | SNV | Missense_Mutation | rs763219876 | c.2086N>T | p.Asp696Tyr | p.D696Y | Q7Z4H7 | protein_coding | deleterious(0) | possibly_damaging(0.874) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HAUS6 | SNV | Missense_Mutation | c.169N>C | p.Ile57Leu | p.I57L | Q7Z4H7 | protein_coding | deleterious(0.03) | benign(0) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HAUS6 | SNV | Missense_Mutation | c.2072N>C | p.Val691Ala | p.V691A | Q7Z4H7 | protein_coding | tolerated(0.15) | benign(0.023) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
HAUS6 | SNV | Missense_Mutation | c.1886N>G | p.His629Arg | p.H629R | Q7Z4H7 | protein_coding | tolerated(0.33) | benign(0.003) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HAUS6 | deletion | Frame_Shift_Del | c.1588delN | p.Ser530ValfsTer12 | p.S530Vfs*12 | Q7Z4H7 | protein_coding | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
HAUS6 | deletion | Frame_Shift_Del | c.1475delA | p.Asn492MetfsTer50 | p.N492Mfs*50 | Q7Z4H7 | protein_coding | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
HAUS6 | SNV | Missense_Mutation | novel | c.2274N>T | p.Gln758His | p.Q758H | Q7Z4H7 | protein_coding | deleterious(0.03) | probably_damaging(0.971) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HAUS6 | SNV | Missense_Mutation | novel | c.1930N>G | p.Thr644Ala | p.T644A | Q7Z4H7 | protein_coding | tolerated(0.26) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HAUS6 | SNV | Missense_Mutation | novel | c.1608N>T | p.Glu536Asp | p.E536D | Q7Z4H7 | protein_coding | tolerated(0.11) | possibly_damaging(0.877) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HAUS6 | SNV | Missense_Mutation | c.1328N>A | p.Cys443Tyr | p.C443Y | Q7Z4H7 | protein_coding | tolerated(1) | benign(0.037) | TCGA-A5-A0VQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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