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Gene: GREB1 |
Gene summary for GREB1 |
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Gene information | Species | Human | Gene symbol | GREB1 | Gene ID | 9687 |
Gene name | growth regulating estrogen receptor binding 1 | |
Gene Alias | GREB1 | |
Cytomap | 2p25.1 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q4ZG55 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9687 | GREB1 | AEH-subject2 | Human | Endometrium | AEH | 1.39e-02 | -1.43e-01 | -0.2525 |
9687 | GREB1 | AEH-subject3 | Human | Endometrium | AEH | 1.10e-03 | 1.87e-01 | -0.2576 |
9687 | GREB1 | AEH-subject5 | Human | Endometrium | AEH | 2.67e-25 | 6.79e-01 | -0.2953 |
9687 | GREB1 | EEC-subject1 | Human | Endometrium | EEC | 2.31e-04 | 1.70e-01 | -0.2682 |
9687 | GREB1 | EEC-subject3 | Human | Endometrium | EEC | 2.84e-03 | -9.50e-03 | -0.2525 |
9687 | GREB1 | GSM5276934 | Human | Endometrium | EEC | 1.64e-04 | -2.03e-01 | -0.0913 |
9687 | GREB1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.15e-12 | -2.44e-01 | -0.1869 |
9687 | GREB1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 8.96e-08 | -2.83e-01 | -0.1875 |
9687 | GREB1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 5.39e-11 | -2.37e-01 | -0.1883 |
9687 | GREB1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 7.35e-09 | -3.29e-03 | -0.1934 |
9687 | GREB1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.00e-13 | -2.08e-01 | -0.1917 |
9687 | GREB1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 4.99e-12 | -2.61e-01 | -0.1916 |
9687 | GREB1 | HCC1_Meng | Human | Liver | HCC | 2.67e-23 | 4.76e-02 | 0.0246 |
9687 | GREB1 | HCC1 | Human | Liver | HCC | 8.64e-03 | 2.13e+00 | 0.5336 |
9687 | GREB1 | HCC2 | Human | Liver | HCC | 2.18e-03 | 4.28e-01 | 0.5341 |
9687 | GREB1 | HCC5 | Human | Liver | HCC | 9.03e-06 | 1.25e+00 | 0.4932 |
9687 | GREB1 | S014 | Human | Liver | HCC | 4.16e-16 | 6.18e-01 | 0.2254 |
9687 | GREB1 | S015 | Human | Liver | HCC | 8.63e-27 | 1.06e+00 | 0.2375 |
9687 | GREB1 | S016 | Human | Liver | HCC | 3.38e-23 | 6.96e-01 | 0.2243 |
9687 | GREB1 | HTA12-23-1 | Human | Pancreas | PDAC | 4.03e-05 | 7.35e-01 | 0.3405 |
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Tissue | Expression Dynamics | Abbreviation |
Endometrium | ![]() | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer | ||
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00016553 | Liver | HCC | urogenital system development | 170/7958 | 338/18723 | 2.15e-03 | 1.08e-02 | 170 |
GO:00018222 | Liver | HCC | kidney development | 148/7958 | 293/18723 | 3.25e-03 | 1.49e-02 | 148 |
GO:00720012 | Liver | HCC | renal system development | 152/7958 | 302/18723 | 3.45e-03 | 1.56e-02 | 152 |
GO:006145811 | Liver | HCC | reproductive system development | 205/7958 | 427/18723 | 1.16e-02 | 4.27e-02 | 205 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GREB1 | SNV | Missense_Mutation | c.4906N>T | p.Asp1636Tyr | p.D1636Y | Q4ZG55 | protein_coding | deleterious(0.04) | possibly_damaging(0.771) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
GREB1 | SNV | Missense_Mutation | c.4901N>T | p.Pro1634Leu | p.P1634L | Q4ZG55 | protein_coding | tolerated(0.14) | benign(0.027) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GREB1 | SNV | Missense_Mutation | rs200385140 | c.4717N>A | p.Val1573Met | p.V1573M | Q4ZG55 | protein_coding | tolerated(0.16) | possibly_damaging(0.617) | TCGA-CA-5256-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | oxaliplatin | CR |
GREB1 | SNV | Missense_Mutation | c.701N>A | p.Ser234Asn | p.S234N | Q4ZG55 | protein_coding | tolerated(0.19) | benign(0.295) | TCGA-CK-4952-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
GREB1 | SNV | Missense_Mutation | c.2915N>T | p.Ala972Val | p.A972V | Q4ZG55 | protein_coding | deleterious(0.02) | benign(0.215) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
GREB1 | SNV | Missense_Mutation | rs752977615 | c.704C>T | p.Thr235Met | p.T235M | Q4ZG55 | protein_coding | deleterious(0.02) | benign(0.006) | TCGA-CM-6677-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GREB1 | SNV | Missense_Mutation | c.2944A>T | p.Ile982Phe | p.I982F | Q4ZG55 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-DM-A1D9-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GREB1 | SNV | Missense_Mutation | c.2975C>T | p.Thr992Ile | p.T992I | Q4ZG55 | protein_coding | tolerated(0.09) | probably_damaging(0.961) | TCGA-DM-A288-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
GREB1 | SNV | Missense_Mutation | rs371972292 | c.4346N>A | p.Arg1449Gln | p.R1449Q | Q4ZG55 | protein_coding | deleterious(0.04) | benign(0.043) | TCGA-G4-6297-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | PD |
GREB1 | SNV | Missense_Mutation | novel | c.1133N>A | p.Cys378Tyr | p.C378Y | Q4ZG55 | protein_coding | deleterious(0.04) | benign(0.12) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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