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Gene: GPR68 |
Gene summary for GPR68 |
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Gene information | Species | Human | Gene symbol | GPR68 | Gene ID | 8111 |
Gene name | G protein-coupled receptor 68 | |
Gene Alias | AI2A6 | |
Cytomap | 14q32.11 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | A1A5B2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8111 | GPR68 | P11T-E | Human | Esophagus | ESCC | 1.16e-09 | 4.29e-01 | 0.1426 |
8111 | GPR68 | P21T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.12e-01 | 0.1617 |
8111 | GPR68 | P32T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.57e-01 | 0.1666 |
8111 | GPR68 | P37T-E | Human | Esophagus | ESCC | 5.34e-06 | 2.26e-01 | 0.1371 |
8111 | GPR68 | P52T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.56e-01 | 0.1555 |
8111 | GPR68 | P62T-E | Human | Esophagus | ESCC | 8.23e-07 | 2.18e-01 | 0.1302 |
8111 | GPR68 | P89T-E | Human | Esophagus | ESCC | 9.70e-15 | 8.95e-01 | 0.1752 |
8111 | GPR68 | P91T-E | Human | Esophagus | ESCC | 3.88e-10 | 8.25e-01 | 0.1828 |
8111 | GPR68 | P130T-E | Human | Esophagus | ESCC | 1.78e-03 | 9.33e-02 | 0.1676 |
8111 | GPR68 | C04 | Human | Oral cavity | OSCC | 2.16e-06 | 4.55e-01 | 0.2633 |
8111 | GPR68 | C21 | Human | Oral cavity | OSCC | 1.33e-20 | 6.33e-01 | 0.2678 |
8111 | GPR68 | C30 | Human | Oral cavity | OSCC | 1.18e-37 | 1.87e+00 | 0.3055 |
8111 | GPR68 | C43 | Human | Oral cavity | OSCC | 1.19e-07 | 2.51e-01 | 0.1704 |
8111 | GPR68 | C51 | Human | Oral cavity | OSCC | 7.11e-08 | 4.95e-01 | 0.2674 |
8111 | GPR68 | C06 | Human | Oral cavity | OSCC | 5.57e-12 | 1.39e+00 | 0.2699 |
8111 | GPR68 | LP15 | Human | Oral cavity | LP | 3.77e-04 | 9.30e-01 | 0.2174 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:0051222111 | Esophagus | ESCC | positive regulation of protein transport | 204/8552 | 303/18723 | 1.56e-14 | 8.38e-13 | 204 |
GO:007121419 | Esophagus | ESCC | cellular response to abiotic stimulus | 206/8552 | 331/18723 | 7.52e-10 | 1.88e-08 | 206 |
GO:010400419 | Esophagus | ESCC | cellular response to environmental stimulus | 206/8552 | 331/18723 | 7.52e-10 | 1.88e-08 | 206 |
GO:0030099111 | Esophagus | ESCC | myeloid cell differentiation | 232/8552 | 381/18723 | 1.22e-09 | 2.90e-08 | 232 |
GO:000257317 | Esophagus | ESCC | myeloid leukocyte differentiation | 128/8552 | 208/18723 | 2.75e-06 | 3.15e-05 | 128 |
GO:001072010 | Esophagus | ESCC | positive regulation of cell development | 172/8552 | 298/18723 | 1.74e-05 | 1.55e-04 | 172 |
GO:1903706110 | Esophagus | ESCC | regulation of hemopoiesis | 201/8552 | 367/18723 | 2.60e-04 | 1.58e-03 | 201 |
GO:19021076 | Esophagus | ESCC | positive regulation of leukocyte differentiation | 93/8552 | 157/18723 | 4.20e-04 | 2.39e-03 | 93 |
GO:19037086 | Esophagus | ESCC | positive regulation of hemopoiesis | 93/8552 | 157/18723 | 4.20e-04 | 2.39e-03 | 93 |
GO:004563918 | Esophagus | ESCC | positive regulation of myeloid cell differentiation | 64/8552 | 103/18723 | 5.54e-04 | 3.03e-03 | 64 |
GO:000268316 | Esophagus | ESCC | negative regulation of immune system process | 231/8552 | 434/18723 | 8.48e-04 | 4.36e-03 | 231 |
GO:19031317 | Esophagus | ESCC | mononuclear cell differentiation | 226/8552 | 426/18723 | 1.20e-03 | 5.88e-03 | 226 |
GO:0045637111 | Esophagus | ESCC | regulation of myeloid cell differentiation | 118/8552 | 210/18723 | 1.35e-03 | 6.43e-03 | 118 |
GO:00603485 | Esophagus | ESCC | bone development | 115/8552 | 205/18723 | 1.67e-03 | 7.72e-03 | 115 |
GO:190210510 | Esophagus | ESCC | regulation of leukocyte differentiation | 152/8552 | 279/18723 | 1.82e-03 | 8.35e-03 | 152 |
GO:000930617 | Esophagus | ESCC | protein secretion | 190/8552 | 359/18723 | 3.22e-03 | 1.34e-02 | 190 |
GO:003022416 | Esophagus | ESCC | monocyte differentiation | 25/8552 | 36/18723 | 3.39e-03 | 1.39e-02 | 25 |
GO:003559217 | Esophagus | ESCC | establishment of protein localization to extracellular region | 190/8552 | 360/18723 | 3.77e-03 | 1.53e-02 | 190 |
GO:000276311 | Esophagus | ESCC | positive regulation of myeloid leukocyte differentiation | 37/8552 | 58/18723 | 4.12e-03 | 1.64e-02 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPR68 | SNV | Missense_Mutation | novel | c.427N>A | p.Val143Met | p.V143M | Q15743 | protein_coding | tolerated(0.07) | benign(0.053) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
GPR68 | SNV | Missense_Mutation | c.629G>A | p.Arg210His | p.R210H | Q15743 | protein_coding | deleterious(0.03) | possibly_damaging(0.829) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8111 | GPR68 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 404859017 | ||
8111 | GPR68 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | allosteric modulator | 178102508 | LORAZEPAM | |
8111 | GPR68 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 404859018 | ||
8111 | GPR68 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 404859019 | ||
8111 | GPR68 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | allosteric modulator | 374883820 | ||
8111 | GPR68 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | allosteric modulator | 385612200 |
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