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Gene: GNAZ |
Gene summary for GNAZ |
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Gene information | Species | Human | Gene symbol | GNAZ | Gene ID | 2781 |
Gene name | G protein subunit alpha z | |
Gene Alias | gz-alpha | |
Cytomap | 22q11.22-q11.23 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | P19086 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2781 | GNAZ | HCC1_Meng | Human | Liver | HCC | 4.58e-11 | 3.26e-02 | 0.0246 |
2781 | GNAZ | HCC2 | Human | Liver | HCC | 1.30e-15 | 3.71e+00 | 0.5341 |
2781 | GNAZ | S014 | Human | Liver | HCC | 1.27e-04 | 1.74e-01 | 0.2254 |
2781 | GNAZ | S015 | Human | Liver | HCC | 7.35e-08 | 2.54e-01 | 0.2375 |
2781 | GNAZ | S016 | Human | Liver | HCC | 1.12e-03 | 1.19e-01 | 0.2243 |
2781 | GNAZ | S027 | Human | Liver | HCC | 2.78e-14 | 6.43e-01 | 0.2446 |
2781 | GNAZ | S028 | Human | Liver | HCC | 5.39e-21 | 5.67e-01 | 0.2503 |
2781 | GNAZ | S029 | Human | Liver | HCC | 8.23e-25 | 7.33e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GNAZ | SNV | Missense_Mutation | rs760505008 | c.41N>A | p.Arg14Gln | p.R14Q | P19086 | protein_coding | tolerated(0.41) | benign(0) | TCGA-D1-A2G0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GNAZ | SNV | Missense_Mutation | c.340G>A | p.Ala114Thr | p.A114T | P19086 | protein_coding | tolerated(0.44) | benign(0.037) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
GNAZ | SNV | Missense_Mutation | novel | c.241N>A | p.Leu81Met | p.L81M | P19086 | protein_coding | tolerated(1) | possibly_damaging(0.479) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
GNAZ | SNV | Missense_Mutation | novel | c.295N>A | p.Asp99Asn | p.D99N | P19086 | protein_coding | tolerated(0.44) | benign(0.091) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GNAZ | SNV | Missense_Mutation | rs780469417 | c.268N>A | p.Ala90Thr | p.A90T | P19086 | protein_coding | tolerated(1) | benign(0) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GNAZ | SNV | Missense_Mutation | novel | c.745N>T | p.Arg249Cys | p.R249C | P19086 | protein_coding | deleterious(0.01) | possibly_damaging(0.568) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GNAZ | SNV | Missense_Mutation | novel | c.916C>T | p.Arg306Trp | p.R306W | P19086 | protein_coding | tolerated(0.09) | possibly_damaging(0.568) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GNAZ | deletion | Frame_Shift_Del | c.612delG | p.Gln205ArgfsTer29 | p.Q205Rfs*29 | P19086 | protein_coding | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |||
GNAZ | insertion | Frame_Shift_Ins | rs752075537 | c.612dupG | p.Gln205AlafsTer35 | p.Q205Afs*35 | P19086 | protein_coding | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
GNAZ | deletion | Frame_Shift_Del | c.606delN | p.Gln205ArgfsTer29 | p.Q205Rfs*29 | P19086 | protein_coding | TCGA-AP-A0LE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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