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Gene: GFRA1 |
Gene summary for GFRA1 |
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Gene information | Species | Human | Gene symbol | GFRA1 | Gene ID | 2674 |
Gene name | GDNF family receptor alpha 1 | |
Gene Alias | GDNFR | |
Cytomap | 10q25.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | P56159 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2674 | GFRA1 | GSM4909293 | Human | Breast | IDC | 3.31e-57 | 7.53e-01 | 0.1581 |
2674 | GFRA1 | GSM4909299 | Human | Breast | IDC | 5.23e-06 | 1.88e-01 | 0.035 |
2674 | GFRA1 | GSM4909300 | Human | Breast | IDC | 1.98e-03 | 2.71e-01 | 0.0334 |
2674 | GFRA1 | GSM4909301 | Human | Breast | IDC | 5.11e-43 | 8.33e-01 | 0.1577 |
2674 | GFRA1 | GSM4909302 | Human | Breast | IDC | 4.79e-16 | 4.62e-01 | 0.1545 |
2674 | GFRA1 | GSM4909304 | Human | Breast | IDC | 9.24e-08 | 2.67e-01 | 0.1636 |
2674 | GFRA1 | GSM4909305 | Human | Breast | IDC | 1.39e-11 | 3.47e-01 | 0.0436 |
2674 | GFRA1 | GSM4909306 | Human | Breast | IDC | 8.00e-15 | 3.90e-01 | 0.1564 |
2674 | GFRA1 | GSM4909307 | Human | Breast | IDC | 3.50e-11 | 3.11e-01 | 0.1569 |
2674 | GFRA1 | GSM4909308 | Human | Breast | IDC | 2.06e-19 | 4.12e-01 | 0.158 |
2674 | GFRA1 | GSM4909311 | Human | Breast | IDC | 1.20e-15 | 6.05e-01 | 0.1534 |
2674 | GFRA1 | GSM4909312 | Human | Breast | IDC | 5.38e-56 | 1.11e+00 | 0.1552 |
2674 | GFRA1 | GSM4909313 | Human | Breast | IDC | 1.53e-02 | 1.89e-01 | 0.0391 |
2674 | GFRA1 | GSM4909321 | Human | Breast | IDC | 5.26e-21 | 6.58e-01 | 0.1559 |
2674 | GFRA1 | M1 | Human | Breast | IDC | 2.47e-38 | 8.45e-01 | 0.1577 |
2674 | GFRA1 | NCCBC2 | Human | Breast | DCIS | 9.92e-05 | 6.21e-01 | 0.1554 |
2674 | GFRA1 | P1 | Human | Breast | IDC | 5.45e-03 | 3.07e-01 | 0.1527 |
2674 | GFRA1 | P3 | Human | Breast | IDC | 3.08e-14 | 7.63e-01 | 0.1542 |
2674 | GFRA1 | DCIS2 | Human | Breast | DCIS | 6.73e-44 | 3.44e-01 | 0.0085 |
2674 | GFRA1 | P10T-E | Human | Esophagus | ESCC | 2.01e-04 | 1.34e-01 | 0.116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GFRA1 | SNV | Missense_Mutation | c.128N>A | p.Ser43Asn | p.S43N | P56159 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AP-A0LG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GFRA1 | SNV | Missense_Mutation | novel | c.1083G>T | p.Gln361His | p.Q361H | P56159 | protein_coding | tolerated(0.12) | possibly_damaging(0.77) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GFRA1 | SNV | Missense_Mutation | novel | c.1189A>G | p.Asn397Asp | p.N397D | P56159 | protein_coding | deleterious(0.01) | benign(0.237) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
GFRA1 | SNV | Missense_Mutation | c.1273N>A | p.Leu425Ile | p.L425I | P56159 | protein_coding | tolerated(0.55) | benign(0.015) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
GFRA1 | SNV | Missense_Mutation | c.565C>T | p.Arg189Cys | p.R189C | P56159 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-AX-A1C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GFRA1 | SNV | Missense_Mutation | novel | c.218N>A | p.Arg73His | p.R73H | P56159 | protein_coding | tolerated(0.12) | probably_damaging(0.949) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
GFRA1 | SNV | Missense_Mutation | novel | c.1148C>A | p.Ser383Tyr | p.S383Y | P56159 | protein_coding | deleterious(0.03) | benign(0.355) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
GFRA1 | SNV | Missense_Mutation | rs747819350 | c.515C>T | p.Ser172Leu | p.S172L | P56159 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A5OC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
GFRA1 | SNV | Missense_Mutation | c.32N>T | p.Pro11Leu | p.P11L | P56159 | protein_coding | tolerated(0.12) | benign(0.285) | TCGA-BG-A187-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GFRA1 | SNV | Missense_Mutation | rs747819350 | c.515C>T | p.Ser172Leu | p.S172L | P56159 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2674 | GFRA1 | KINASE, EXTERNAL SIDE OF PLASMA MEMBRANE | 178101552 | |||
2674 | GFRA1 | KINASE, EXTERNAL SIDE OF PLASMA MEMBRANE | PYM50028 | |||
2674 | GFRA1 | KINASE, EXTERNAL SIDE OF PLASMA MEMBRANE | ANTISENSE OLIGONUCLEOTIDES | 11079571 |
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