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Gene: FRA10AC1 |
Gene summary for FRA10AC1 |
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Gene information | Species | Human | Gene symbol | FRA10AC1 | Gene ID | 118924 |
Gene name | FRA10A associated CGG repeat 1 | |
Gene Alias | C10orf4 | |
Cytomap | 10q23.33 | |
Gene Type | protein-coding | GO ID | GO:0006793 | UniProtAcc | Q70Z53 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
118924 | FRA10AC1 | LZE4T | Human | Esophagus | ESCC | 4.95e-14 | 2.71e-01 | 0.0811 |
118924 | FRA10AC1 | LZE5T | Human | Esophagus | ESCC | 3.68e-03 | 1.42e-01 | 0.0514 |
118924 | FRA10AC1 | LZE7T | Human | Esophagus | ESCC | 1.93e-04 | 2.74e-01 | 0.0667 |
118924 | FRA10AC1 | LZE8T | Human | Esophagus | ESCC | 2.27e-04 | 1.13e-01 | 0.067 |
118924 | FRA10AC1 | LZE22D1 | Human | Esophagus | HGIN | 3.89e-02 | 1.28e-01 | 0.0595 |
118924 | FRA10AC1 | LZE24T | Human | Esophagus | ESCC | 2.15e-14 | 3.41e-01 | 0.0596 |
118924 | FRA10AC1 | LZE21T | Human | Esophagus | ESCC | 2.41e-02 | 2.99e-01 | 0.0655 |
118924 | FRA10AC1 | P1T-E | Human | Esophagus | ESCC | 2.68e-02 | 9.41e-02 | 0.0875 |
118924 | FRA10AC1 | P2T-E | Human | Esophagus | ESCC | 1.29e-32 | 5.23e-01 | 0.1177 |
118924 | FRA10AC1 | P4T-E | Human | Esophagus | ESCC | 2.08e-25 | 5.10e-01 | 0.1323 |
118924 | FRA10AC1 | P5T-E | Human | Esophagus | ESCC | 6.52e-18 | 2.64e-01 | 0.1327 |
118924 | FRA10AC1 | P8T-E | Human | Esophagus | ESCC | 1.75e-18 | 2.50e-01 | 0.0889 |
118924 | FRA10AC1 | P9T-E | Human | Esophagus | ESCC | 3.54e-13 | 2.05e-01 | 0.1131 |
118924 | FRA10AC1 | P10T-E | Human | Esophagus | ESCC | 4.70e-18 | 2.55e-01 | 0.116 |
118924 | FRA10AC1 | P11T-E | Human | Esophagus | ESCC | 1.13e-12 | 4.17e-01 | 0.1426 |
118924 | FRA10AC1 | P12T-E | Human | Esophagus | ESCC | 6.07e-32 | 5.92e-01 | 0.1122 |
118924 | FRA10AC1 | P15T-E | Human | Esophagus | ESCC | 2.59e-26 | 5.03e-01 | 0.1149 |
118924 | FRA10AC1 | P16T-E | Human | Esophagus | ESCC | 3.54e-28 | 4.30e-01 | 0.1153 |
118924 | FRA10AC1 | P17T-E | Human | Esophagus | ESCC | 3.05e-08 | 2.92e-01 | 0.1278 |
118924 | FRA10AC1 | P20T-E | Human | Esophagus | ESCC | 1.42e-30 | 6.13e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:001631111 | Liver | Cirrhotic | dephosphorylation | 130/4634 | 417/18723 | 1.58e-03 | 1.03e-02 | 130 |
GO:001631121 | Liver | HCC | dephosphorylation | 230/7958 | 417/18723 | 1.00e-07 | 1.96e-06 | 230 |
GO:00163119 | Oral cavity | OSCC | dephosphorylation | 220/7305 | 417/18723 | 6.33e-09 | 1.34e-07 | 220 |
GO:001631116 | Thyroid | PTC | dephosphorylation | 174/5968 | 417/18723 | 1.20e-05 | 1.31e-04 | 174 |
GO:001631117 | Thyroid | ATC | dephosphorylation | 179/6293 | 417/18723 | 3.88e-05 | 3.15e-04 | 179 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FRA10AC1 | deletion | Frame_Shift_Del | rs775948504 | c.694delN | p.Arg232GlufsTer96 | p.R232Efs*96 | Q70Z53 | protein_coding | TCGA-E6-A2P9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FRA10AC1 | SNV | Missense_Mutation | c.487N>C | p.Glu163Gln | p.E163Q | Q70Z53 | protein_coding | deleterious(0.02) | possibly_damaging(0.765) | TCGA-60-2698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | mithramycin | PD | |
FRA10AC1 | SNV | Missense_Mutation | rs771692369 | c.251N>G | p.Tyr84Cys | p.Y84C | Q70Z53 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-66-2755-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FRA10AC1 | SNV | Missense_Mutation | novel | c.309N>C | p.Lys103Asn | p.K103N | Q70Z53 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-BA-6872-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unspecific | PD | |
FRA10AC1 | SNV | Missense_Mutation | novel | c.814N>A | p.Asp272Asn | p.D272N | Q70Z53 | protein_coding | tolerated(0.14) | benign(0) | TCGA-CV-5436-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FRA10AC1 | SNV | Missense_Mutation | novel | c.139G>A | p.Ala47Thr | p.A47T | Q70Z53 | protein_coding | tolerated(0.32) | benign(0.033) | TCGA-RS-A6TO-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Immunotherapy | cetuximab | PD |
FRA10AC1 | SNV | Missense_Mutation | c.43G>A | p.Glu15Lys | p.E15K | Q70Z53 | protein_coding | deleterious(0.03) | benign(0.15) | TCGA-T3-A92N-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FRA10AC1 | insertion | Frame_Shift_Ins | novel | c.543_544insGCTAAAAATGT | p.Lys182AlafsTer9 | p.K182Afs*9 | Q70Z53 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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