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Gene: FKBP10 |
Gene summary for FKBP10 |
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Gene information | Species | Human | Gene symbol | FKBP10 | Gene ID | 60681 |
Gene name | FKBP prolyl isomerase 10 | |
Gene Alias | BRKS1 | |
Cytomap | 17q21.2 | |
Gene Type | protein-coding | GO ID | GO:0000413 | UniProtAcc | A0A024R1W3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
60681 | FKBP10 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.14e-02 | 1.98e-01 | -0.1808 |
60681 | FKBP10 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.61e-02 | 1.02e-01 | -0.1464 |
60681 | FKBP10 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.40e-03 | 3.08e-01 | 0.0446 |
60681 | FKBP10 | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.37e-05 | 2.47e-01 | 0.0528 |
60681 | FKBP10 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.37e-04 | 1.94e-01 | 0.0588 |
60681 | FKBP10 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 7.89e-03 | 3.79e-01 | 0.3487 |
60681 | FKBP10 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.05e-22 | 6.06e-01 | 0.281 |
60681 | FKBP10 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.94e-18 | 7.20e-01 | 0.2585 |
60681 | FKBP10 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.80e-25 | 4.66e-01 | 0.3005 |
60681 | FKBP10 | A015-C-006 | Human | Colorectum | FAP | 3.48e-02 | 2.68e-01 | -0.0994 |
60681 | FKBP10 | AEH-subject1 | Human | Endometrium | AEH | 9.86e-33 | -5.13e-01 | -0.3059 |
60681 | FKBP10 | AEH-subject2 | Human | Endometrium | AEH | 1.72e-30 | -4.86e-01 | -0.2525 |
60681 | FKBP10 | AEH-subject3 | Human | Endometrium | AEH | 6.15e-20 | -4.91e-01 | -0.2576 |
60681 | FKBP10 | AEH-subject4 | Human | Endometrium | AEH | 4.39e-18 | -4.30e-01 | -0.2657 |
60681 | FKBP10 | AEH-subject5 | Human | Endometrium | AEH | 1.14e-23 | -5.01e-01 | -0.2953 |
60681 | FKBP10 | EEC-subject1 | Human | Endometrium | EEC | 5.44e-23 | -4.99e-01 | -0.2682 |
60681 | FKBP10 | EEC-subject2 | Human | Endometrium | EEC | 7.46e-29 | -5.17e-01 | -0.2607 |
60681 | FKBP10 | EEC-subject3 | Human | Endometrium | EEC | 1.02e-31 | -4.92e-01 | -0.2525 |
60681 | FKBP10 | EEC-subject4 | Human | Endometrium | EEC | 4.78e-26 | -5.04e-01 | -0.2571 |
60681 | FKBP10 | EEC-subject5 | Human | Endometrium | EEC | 6.96e-32 | -5.16e-01 | -0.249 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042060 | Colorectum | AD | wound healing | 128/3918 | 422/18723 | 2.73e-06 | 7.89e-05 | 128 |
GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
GO:00420601 | Colorectum | SER | wound healing | 97/2897 | 422/18723 | 2.69e-05 | 7.30e-04 | 97 |
GO:00017011 | Colorectum | SER | in utero embryonic development | 77/2897 | 367/18723 | 2.77e-03 | 2.48e-02 | 77 |
GO:00420602 | Colorectum | MSS | wound healing | 119/3467 | 422/18723 | 5.93e-07 | 2.24e-05 | 119 |
GO:00017012 | Colorectum | MSS | in utero embryonic development | 99/3467 | 367/18723 | 3.71e-05 | 7.10e-04 | 99 |
GO:00420603 | Colorectum | MSI-H | wound healing | 47/1319 | 422/18723 | 1.23e-03 | 2.00e-02 | 47 |
GO:00420604 | Colorectum | FAP | wound healing | 99/2622 | 422/18723 | 9.50e-08 | 6.33e-06 | 99 |
GO:00017013 | Colorectum | FAP | in utero embryonic development | 81/2622 | 367/18723 | 1.58e-05 | 4.10e-04 | 81 |
GO:004206016 | Endometrium | AEH | wound healing | 91/2100 | 422/18723 | 4.85e-10 | 4.61e-08 | 91 |
GO:00017019 | Endometrium | AEH | in utero embryonic development | 73/2100 | 367/18723 | 7.18e-07 | 2.63e-05 | 73 |
GO:00004133 | Endometrium | AEH | protein peptidyl-prolyl isomerization | 13/2100 | 42/18723 | 4.74e-04 | 4.91e-03 | 13 |
GO:00182086 | Endometrium | AEH | peptidyl-proline modification | 16/2100 | 58/18723 | 4.75e-04 | 4.91e-03 | 16 |
GO:0030199 | Endometrium | AEH | collagen fibril organization | 14/2100 | 61/18723 | 6.65e-03 | 3.91e-02 | 14 |
GO:004206017 | Endometrium | EEC | wound healing | 92/2168 | 422/18723 | 1.12e-09 | 9.58e-08 | 92 |
GO:000170114 | Endometrium | EEC | in utero embryonic development | 75/2168 | 367/18723 | 5.86e-07 | 2.16e-05 | 75 |
GO:000041311 | Endometrium | EEC | protein peptidyl-prolyl isomerization | 14/2168 | 42/18723 | 1.69e-04 | 2.10e-03 | 14 |
GO:001820813 | Endometrium | EEC | peptidyl-proline modification | 17/2168 | 58/18723 | 2.11e-04 | 2.54e-03 | 17 |
GO:00301991 | Endometrium | EEC | collagen fibril organization | 14/2168 | 61/18723 | 8.76e-03 | 4.74e-02 | 14 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FKBP10 | SNV | Missense_Mutation | novel | c.1019N>T | p.Arg340Ile | p.R340I | Q96AY3 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FKBP10 | SNV | Missense_Mutation | novel | c.197N>A | p.Arg66His | p.R66H | Q96AY3 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FKBP10 | SNV | Missense_Mutation | rs397514674 | c.337N>A | p.Glu113Lys | p.E113K | Q96AY3 | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
FKBP10 | SNV | Missense_Mutation | rs782331928 | c.1623N>T | p.Gln541His | p.Q541H | Q96AY3 | protein_coding | tolerated(0.54) | benign(0.423) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
FKBP10 | SNV | Missense_Mutation | novel | c.952G>T | p.Gly318Trp | p.G318W | Q96AY3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
FKBP10 | SNV | Missense_Mutation | novel | c.1540N>T | p.Asp514Tyr | p.D514Y | Q96AY3 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FKBP10 | SNV | Missense_Mutation | c.1730N>T | p.Arg577Leu | p.R577L | Q96AY3 | protein_coding | tolerated(0.13) | benign(0.196) | TCGA-78-7536-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
FKBP10 | SNV | Missense_Mutation | c.898N>A | p.Gly300Ser | p.G300S | Q96AY3 | protein_coding | tolerated(0.06) | possibly_damaging(0.775) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FKBP10 | SNV | Missense_Mutation | c.376N>T | p.Gly126Trp | p.G126W | Q96AY3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-97-8174-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | vinorelbine | SD | |
FKBP10 | SNV | Missense_Mutation | c.638N>A | p.Gly213Asp | p.G213D | Q96AY3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-18-3411-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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