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Gene: FBXL17 |
Gene summary for FBXL17 |
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Gene information | Species | Human | Gene symbol | FBXL17 | Gene ID | 64839 |
Gene name | F-box and leucine rich repeat protein 17 | |
Gene Alias | FBXO13 | |
Cytomap | 5q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000086 | UniProtAcc | Q9UF56 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64839 | FBXL17 | CCI_2 | Human | Cervix | CC | 1.34e-13 | 1.12e+00 | 0.5249 |
64839 | FBXL17 | CCI_3 | Human | Cervix | CC | 1.06e-16 | 1.03e+00 | 0.516 |
64839 | FBXL17 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.31e-39 | -8.45e-01 | 0.0155 |
64839 | FBXL17 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.81e-03 | -5.13e-01 | -0.1808 |
64839 | FBXL17 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.18e-07 | -1.07e+00 | 0.0216 |
64839 | FBXL17 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.22e-16 | -8.42e-01 | -0.1207 |
64839 | FBXL17 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.82e-13 | -4.16e-01 | -0.1464 |
64839 | FBXL17 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.10e-07 | -3.11e-01 | -0.1001 |
64839 | FBXL17 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.82e-06 | -5.06e-01 | -0.059 |
64839 | FBXL17 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.82e-08 | -7.64e-01 | -0.2061 |
64839 | FBXL17 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.96e-16 | -7.51e-01 | 0.096 |
64839 | FBXL17 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.04e-04 | -5.86e-01 | 0.0446 |
64839 | FBXL17 | HTA11_9408_2000001011 | Human | Colorectum | AD | 3.19e-02 | -8.56e-01 | 0.0451 |
64839 | FBXL17 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.43e-10 | -8.39e-01 | 0.0528 |
64839 | FBXL17 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.32e-09 | -5.81e-01 | 0.0338 |
64839 | FBXL17 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.56e-26 | -6.51e-01 | 0.0674 |
64839 | FBXL17 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.84e-05 | -5.58e-01 | 0.0112 |
64839 | FBXL17 | HTA11_11156_2000001011 | Human | Colorectum | AD | 1.08e-02 | -9.48e-01 | 0.0397 |
64839 | FBXL17 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.10e-04 | -4.21e-01 | 0.0588 |
64839 | FBXL17 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.51e-20 | -5.25e-01 | 0.294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:00002097 | Cervix | CC | protein polyubiquitination | 58/2311 | 236/18723 | 1.57e-07 | 7.41e-06 | 58 |
GO:00447725 | Cervix | CC | mitotic cell cycle phase transition | 89/2311 | 424/18723 | 2.70e-07 | 1.12e-05 | 89 |
GO:00485118 | Cervix | CC | rhythmic process | 65/2311 | 298/18723 | 2.79e-06 | 8.04e-05 | 65 |
GO:00093149 | Cervix | CC | response to radiation | 86/2311 | 456/18723 | 3.50e-05 | 5.63e-04 | 86 |
GO:00488634 | Cervix | CC | stem cell differentiation | 46/2311 | 206/18723 | 4.11e-05 | 6.36e-04 | 46 |
GO:00076238 | Cervix | CC | circadian rhythm | 46/2311 | 210/18723 | 6.76e-05 | 9.60e-04 | 46 |
GO:00448392 | Cervix | CC | cell cycle G2/M phase transition | 31/2311 | 148/18723 | 2.07e-03 | 1.51e-02 | 31 |
GO:00000862 | Cervix | CC | G2/M transition of mitotic cell cycle | 29/2311 | 137/18723 | 2.40e-03 | 1.70e-02 | 29 |
GO:00487624 | Cervix | CC | mesenchymal cell differentiation | 42/2311 | 236/18723 | 9.12e-03 | 4.60e-02 | 42 |
GO:00094163 | Cervix | CC | response to light stimulus | 54/2311 | 320/18723 | 1.03e-02 | 4.97e-02 | 54 |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
GO:0007623 | Colorectum | AD | circadian rhythm | 72/3918 | 210/18723 | 4.50e-06 | 1.21e-04 | 72 |
GO:0000209 | Colorectum | AD | protein polyubiquitination | 78/3918 | 236/18723 | 8.71e-06 | 2.06e-04 | 78 |
GO:0048511 | Colorectum | AD | rhythmic process | 94/3918 | 298/18723 | 1.00e-05 | 2.34e-04 | 94 |
GO:0006515 | Colorectum | AD | protein quality control for misfolded or incompletely synthesized proteins | 14/3918 | 28/18723 | 6.01e-04 | 6.33e-03 | 14 |
GO:0042752 | Colorectum | AD | regulation of circadian rhythm | 40/3918 | 121/18723 | 1.24e-03 | 1.09e-02 | 40 |
GO:00104981 | Colorectum | SER | proteasomal protein catabolic process | 132/2897 | 490/18723 | 3.08e-11 | 5.55e-09 | 132 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBXL17 | SNV | Missense_Mutation | c.1229N>C | p.Lys410Thr | p.K410T | Q9UF56 | protein_coding | deleterious(0.03) | benign(0.258) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FBXL17 | SNV | Missense_Mutation | novel | c.1649N>C | p.Ile550Thr | p.I550T | Q9UF56 | protein_coding | deleterious(0.01) | possibly_damaging(0.761) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
FBXL17 | SNV | Missense_Mutation | novel | c.1216G>T | p.Val406Phe | p.V406F | Q9UF56 | protein_coding | tolerated(0.22) | benign(0.314) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
FBXL17 | SNV | Missense_Mutation | novel | c.1481N>T | p.Arg494Met | p.R494M | Q9UF56 | protein_coding | deleterious(0.01) | possibly_damaging(0.819) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FBXL17 | SNV | Missense_Mutation | rs781459902 | c.1190N>A | p.Arg397His | p.R397H | Q9UF56 | protein_coding | deleterious(0.04) | probably_damaging(0.925) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FBXL17 | deletion | Frame_Shift_Del | novel | c.1499delA | p.Asn500ThrfsTer3 | p.N500Tfs*3 | Q9UF56 | protein_coding | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FBXL17 | SNV | Missense_Mutation | c.2072N>T | p.Gly691Val | p.G691V | Q9UF56 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.786) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD | |
FBXL17 | SNV | Missense_Mutation | c.1513N>T | p.Asp505Tyr | p.D505Y | Q9UF56 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-53-7626-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unspecific | Cisplatin | PD | |
FBXL17 | SNV | Missense_Mutation | c.1134N>T | p.Leu378Phe | p.L378F | Q9UF56 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-55-7995-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
FBXL17 | SNV | Missense_Mutation | c.1157N>G | p.Gln386Arg | p.Q386R | Q9UF56 | protein_coding | tolerated(0.21) | possibly_damaging(0.543) | TCGA-73-4676-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
64839 | FBXL17 | TUMOR SUPPRESSOR | hydrochlorothiazide | HYDROCHLOROTHIAZIDE |
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