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Gene: FANCE |
Gene summary for FANCE |
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Gene information | Species | Human | Gene symbol | FANCE | Gene ID | 2178 |
Gene name | FA complementation group E | |
Gene Alias | FACE | |
Cytomap | 6p21.31 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9HB96 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2178 | FANCE | P1T-E | Human | Esophagus | ESCC | 8.13e-03 | 1.53e-01 | 0.0875 |
2178 | FANCE | P2T-E | Human | Esophagus | ESCC | 1.57e-07 | 1.90e-01 | 0.1177 |
2178 | FANCE | P4T-E | Human | Esophagus | ESCC | 9.14e-08 | 2.03e-01 | 0.1323 |
2178 | FANCE | P5T-E | Human | Esophagus | ESCC | 2.32e-02 | 1.31e-01 | 0.1327 |
2178 | FANCE | P8T-E | Human | Esophagus | ESCC | 2.78e-02 | 5.44e-02 | 0.0889 |
2178 | FANCE | P9T-E | Human | Esophagus | ESCC | 7.15e-07 | 2.09e-01 | 0.1131 |
2178 | FANCE | P10T-E | Human | Esophagus | ESCC | 1.41e-03 | 9.02e-02 | 0.116 |
2178 | FANCE | P12T-E | Human | Esophagus | ESCC | 2.41e-11 | 2.73e-01 | 0.1122 |
2178 | FANCE | P15T-E | Human | Esophagus | ESCC | 1.86e-11 | 1.74e-01 | 0.1149 |
2178 | FANCE | P17T-E | Human | Esophagus | ESCC | 1.42e-02 | 2.10e-01 | 0.1278 |
2178 | FANCE | P21T-E | Human | Esophagus | ESCC | 4.39e-05 | 1.56e-01 | 0.1617 |
2178 | FANCE | P22T-E | Human | Esophagus | ESCC | 6.95e-06 | 1.81e-01 | 0.1236 |
2178 | FANCE | P23T-E | Human | Esophagus | ESCC | 3.12e-04 | 1.73e-01 | 0.108 |
2178 | FANCE | P24T-E | Human | Esophagus | ESCC | 3.49e-02 | 8.66e-02 | 0.1287 |
2178 | FANCE | P26T-E | Human | Esophagus | ESCC | 1.34e-03 | 7.61e-02 | 0.1276 |
2178 | FANCE | P27T-E | Human | Esophagus | ESCC | 1.48e-05 | 1.38e-01 | 0.1055 |
2178 | FANCE | P28T-E | Human | Esophagus | ESCC | 1.17e-13 | 3.25e-01 | 0.1149 |
2178 | FANCE | P30T-E | Human | Esophagus | ESCC | 1.75e-11 | 4.03e-01 | 0.137 |
2178 | FANCE | P31T-E | Human | Esophagus | ESCC | 5.97e-10 | 2.51e-01 | 0.1251 |
2178 | FANCE | P37T-E | Human | Esophagus | ESCC | 3.10e-10 | 1.96e-01 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FANCE | insertion | Frame_Shift_Ins | rs749898067 | c.922_923insC | p.Val311SerfsTer2 | p.V311Sfs*2 | Q9HB96 | protein_coding | TCGA-EY-A1GK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FANCE | insertion | Frame_Shift_Ins | rs749898067 | c.922_923insC | p.Val311SerfsTer2 | p.V311Sfs*2 | Q9HB96 | protein_coding | TCGA-FI-A2D6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FANCE | deletion | Frame_Shift_Del | rs587778337 | c.929delC | p.Pro310GlnfsTer54 | p.P310Qfs*54 | Q9HB96 | protein_coding | TCGA-SL-A6JA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FANCE | SNV | Missense_Mutation | novel | c.1520N>G | p.Thr507Ser | p.T507S | Q9HB96 | protein_coding | tolerated(0.15) | benign(0.015) | TCGA-2Y-A9HB-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FANCE | SNV | Missense_Mutation | c.1328A>G | p.Glu443Gly | p.E443G | Q9HB96 | protein_coding | deleterious(0) | possibly_damaging(0.821) | TCGA-LG-A6GG-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FANCE | SNV | Missense_Mutation | rs755510065 | c.971N>C | p.Met324Thr | p.M324T | Q9HB96 | protein_coding | deleterious(0) | benign(0.074) | TCGA-44-2656-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
FANCE | SNV | Missense_Mutation | c.534G>T | p.Leu178Phe | p.L178F | Q9HB96 | protein_coding | deleterious(0.01) | possibly_damaging(0.861) | TCGA-49-AARQ-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FANCE | SNV | Missense_Mutation | rs533815063 | c.787G>A | p.Glu263Lys | p.E263K | Q9HB96 | protein_coding | tolerated(0.18) | benign(0) | TCGA-NJ-A4YP-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FANCE | SNV | Missense_Mutation | rs766747763 | c.1048G>C | p.Ala350Pro | p.A350P | Q9HB96 | protein_coding | deleterious(0.02) | possibly_damaging(0.621) | TCGA-21-1081-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FANCE | SNV | Missense_Mutation | c.769N>C | p.Met257Leu | p.M257L | Q9HB96 | protein_coding | tolerated(0.38) | benign(0) | TCGA-34-2604-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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