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Gene: FAM91A1 |
Gene summary for FAM91A1 |
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Gene information | Species | Human | Gene symbol | FAM91A1 | Gene ID | 157769 |
Gene name | family with sequence similarity 91 member A1 | |
Gene Alias | FAM91A1 | |
Cytomap | 8q24.13 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q658Y4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
157769 | FAM91A1 | LZE4T | Human | Esophagus | ESCC | 3.66e-19 | 2.80e-01 | 0.0811 |
157769 | FAM91A1 | LZE8T | Human | Esophagus | ESCC | 4.23e-02 | 9.69e-04 | 0.067 |
157769 | FAM91A1 | LZE20T | Human | Esophagus | ESCC | 5.33e-12 | 3.02e-01 | 0.0662 |
157769 | FAM91A1 | LZE22T | Human | Esophagus | ESCC | 1.79e-04 | 1.08e-01 | 0.068 |
157769 | FAM91A1 | LZE24T | Human | Esophagus | ESCC | 4.26e-17 | 3.01e-01 | 0.0596 |
157769 | FAM91A1 | P1T-E | Human | Esophagus | ESCC | 2.52e-09 | 2.38e-01 | 0.0875 |
157769 | FAM91A1 | P2T-E | Human | Esophagus | ESCC | 1.15e-22 | 2.54e-01 | 0.1177 |
157769 | FAM91A1 | P4T-E | Human | Esophagus | ESCC | 4.46e-10 | 3.85e-01 | 0.1323 |
157769 | FAM91A1 | P5T-E | Human | Esophagus | ESCC | 1.01e-16 | 2.76e-01 | 0.1327 |
157769 | FAM91A1 | P8T-E | Human | Esophagus | ESCC | 2.41e-23 | 2.03e-01 | 0.0889 |
157769 | FAM91A1 | P9T-E | Human | Esophagus | ESCC | 2.56e-15 | 2.18e-01 | 0.1131 |
157769 | FAM91A1 | P10T-E | Human | Esophagus | ESCC | 1.72e-14 | 2.30e-01 | 0.116 |
157769 | FAM91A1 | P11T-E | Human | Esophagus | ESCC | 7.23e-16 | 4.64e-01 | 0.1426 |
157769 | FAM91A1 | P12T-E | Human | Esophagus | ESCC | 3.96e-15 | 3.32e-01 | 0.1122 |
157769 | FAM91A1 | P15T-E | Human | Esophagus | ESCC | 1.41e-23 | 4.31e-01 | 0.1149 |
157769 | FAM91A1 | P16T-E | Human | Esophagus | ESCC | 1.11e-20 | 3.91e-01 | 0.1153 |
157769 | FAM91A1 | P17T-E | Human | Esophagus | ESCC | 1.06e-08 | 2.99e-01 | 0.1278 |
157769 | FAM91A1 | P19T-E | Human | Esophagus | ESCC | 3.60e-02 | 4.28e-01 | 0.1662 |
157769 | FAM91A1 | P20T-E | Human | Esophagus | ESCC | 2.16e-14 | 3.50e-01 | 0.1124 |
157769 | FAM91A1 | P21T-E | Human | Esophagus | ESCC | 3.96e-27 | 4.57e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:005165016 | Esophagus | ESCC | establishment of vesicle localization | 114/8552 | 161/18723 | 8.20e-11 | 2.53e-09 | 114 |
GO:005164815 | Esophagus | ESCC | vesicle localization | 119/8552 | 177/18723 | 5.16e-09 | 1.08e-07 | 119 |
GO:00069038 | Esophagus | ESCC | vesicle targeting | 38/8552 | 45/18723 | 8.42e-08 | 1.43e-06 | 38 |
GO:00990222 | Esophagus | ESCC | vesicle tethering | 10/8552 | 11/18723 | 2.54e-03 | 1.08e-02 | 10 |
GO:005165621 | Liver | HCC | establishment of organelle localization | 226/7958 | 390/18723 | 4.15e-10 | 1.34e-08 | 226 |
GO:005165021 | Liver | HCC | establishment of vesicle localization | 103/7958 | 161/18723 | 2.94e-08 | 6.69e-07 | 103 |
GO:005164821 | Liver | HCC | vesicle localization | 107/7958 | 177/18723 | 1.05e-06 | 1.57e-05 | 107 |
GO:000690311 | Liver | HCC | vesicle targeting | 34/7958 | 45/18723 | 6.75e-06 | 8.08e-05 | 34 |
GO:005165610 | Oral cavity | OSCC | establishment of organelle localization | 239/7305 | 390/18723 | 2.46e-19 | 3.31e-17 | 239 |
GO:00069037 | Oral cavity | OSCC | vesicle targeting | 38/7305 | 45/18723 | 4.49e-10 | 1.19e-08 | 38 |
GO:00516509 | Oral cavity | OSCC | establishment of vesicle localization | 101/7305 | 161/18723 | 8.79e-10 | 2.17e-08 | 101 |
GO:00516489 | Oral cavity | OSCC | vesicle localization | 105/7305 | 177/18723 | 3.30e-08 | 6.30e-07 | 105 |
GO:0099022 | Oral cavity | OSCC | vesicle tethering | 10/7305 | 11/18723 | 5.78e-04 | 3.30e-03 | 10 |
GO:005165615 | Oral cavity | LP | establishment of organelle localization | 147/4623 | 390/18723 | 6.01e-09 | 2.46e-07 | 147 |
GO:000690314 | Oral cavity | LP | vesicle targeting | 27/4623 | 45/18723 | 5.03e-07 | 1.40e-05 | 27 |
GO:005165015 | Oral cavity | LP | establishment of vesicle localization | 64/4623 | 161/18723 | 1.65e-05 | 2.86e-04 | 64 |
GO:005164814 | Oral cavity | LP | vesicle localization | 66/4623 | 177/18723 | 1.25e-04 | 1.46e-03 | 66 |
GO:005165623 | Oral cavity | EOLP | establishment of organelle localization | 73/2218 | 390/18723 | 4.59e-05 | 6.11e-04 | 73 |
GO:005165022 | Oral cavity | EOLP | establishment of vesicle localization | 35/2218 | 161/18723 | 2.54e-04 | 2.47e-03 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM91A1 | SNV | Missense_Mutation | rs749293427 | c.2170G>A | p.Glu724Lys | p.E724K | Q658Y4 | protein_coding | tolerated(0.05) | benign(0.148) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
FAM91A1 | SNV | Missense_Mutation | rs760648737 | c.1135N>A | p.Ala379Thr | p.A379T | Q658Y4 | protein_coding | deleterious(0) | possibly_damaging(0.905) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
FAM91A1 | SNV | Missense_Mutation | novel | c.722N>G | p.Phe241Cys | p.F241C | Q658Y4 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM91A1 | SNV | Missense_Mutation | rs760648737 | c.1135N>A | p.Ala379Thr | p.A379T | Q658Y4 | protein_coding | deleterious(0) | possibly_damaging(0.905) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
FAM91A1 | SNV | Missense_Mutation | novel | c.2000N>G | p.Asp667Gly | p.D667G | Q658Y4 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
FAM91A1 | SNV | Missense_Mutation | c.965N>A | p.Ser322Asn | p.S322N | Q658Y4 | protein_coding | tolerated(0.41) | benign(0.034) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM91A1 | SNV | Missense_Mutation | novel | c.2429N>G | p.Lys810Arg | p.K810R | Q658Y4 | protein_coding | tolerated(0.65) | benign(0) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM91A1 | SNV | Missense_Mutation | c.1372N>A | p.Leu458Ile | p.L458I | Q658Y4 | protein_coding | tolerated(0.13) | benign(0.111) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FAM91A1 | SNV | Missense_Mutation | novel | c.146N>T | p.Arg49Ile | p.R49I | Q658Y4 | protein_coding | tolerated(0.09) | probably_damaging(0.994) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM91A1 | SNV | Missense_Mutation | novel | c.1130N>A | p.Arg377His | p.R377H | Q658Y4 | protein_coding | deleterious(0.02) | benign(0.097) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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