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Gene: FAM83F |
Gene summary for FAM83F |
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Gene information | Species | Human | Gene symbol | FAM83F | Gene ID | 113828 |
Gene name | family with sequence similarity 83 member F | |
Gene Alias | FAM83F | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q8NEG4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
113828 | FAM83F | LZE2T | Human | Esophagus | ESCC | 2.19e-02 | 2.47e-01 | 0.082 |
113828 | FAM83F | LZE4T | Human | Esophagus | ESCC | 8.28e-04 | 4.93e-02 | 0.0811 |
113828 | FAM83F | LZE7T | Human | Esophagus | ESCC | 3.76e-04 | 1.53e-01 | 0.0667 |
113828 | FAM83F | LZE24T | Human | Esophagus | ESCC | 1.75e-11 | 8.16e-02 | 0.0596 |
113828 | FAM83F | LZE21T | Human | Esophagus | ESCC | 5.15e-03 | 1.21e-01 | 0.0655 |
113828 | FAM83F | P1T-E | Human | Esophagus | ESCC | 7.83e-04 | 2.52e-01 | 0.0875 |
113828 | FAM83F | P2T-E | Human | Esophagus | ESCC | 1.55e-11 | 1.20e-01 | 0.1177 |
113828 | FAM83F | P4T-E | Human | Esophagus | ESCC | 3.08e-25 | 5.68e-01 | 0.1323 |
113828 | FAM83F | P5T-E | Human | Esophagus | ESCC | 3.69e-06 | 7.57e-02 | 0.1327 |
113828 | FAM83F | P8T-E | Human | Esophagus | ESCC | 4.09e-07 | 1.84e-01 | 0.0889 |
113828 | FAM83F | P9T-E | Human | Esophagus | ESCC | 3.76e-09 | 1.73e-01 | 0.1131 |
113828 | FAM83F | P10T-E | Human | Esophagus | ESCC | 3.15e-03 | 5.42e-02 | 0.116 |
113828 | FAM83F | P12T-E | Human | Esophagus | ESCC | 1.29e-03 | 8.87e-02 | 0.1122 |
113828 | FAM83F | P15T-E | Human | Esophagus | ESCC | 1.06e-14 | 1.81e-01 | 0.1149 |
113828 | FAM83F | P16T-E | Human | Esophagus | ESCC | 3.61e-14 | 5.05e-02 | 0.1153 |
113828 | FAM83F | P20T-E | Human | Esophagus | ESCC | 2.21e-11 | 9.81e-02 | 0.1124 |
113828 | FAM83F | P21T-E | Human | Esophagus | ESCC | 2.09e-12 | 2.76e-01 | 0.1617 |
113828 | FAM83F | P22T-E | Human | Esophagus | ESCC | 5.65e-16 | 2.64e-01 | 0.1236 |
113828 | FAM83F | P23T-E | Human | Esophagus | ESCC | 2.08e-16 | 3.83e-01 | 0.108 |
113828 | FAM83F | P24T-E | Human | Esophagus | ESCC | 5.80e-08 | 7.53e-02 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM83F | SNV | Missense_Mutation | novel | c.926N>T | p.Arg309Met | p.R309M | Q8NEG4 | protein_coding | tolerated(0.13) | benign(0.219) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
FAM83F | SNV | Missense_Mutation | novel | c.824N>C | p.Leu275Pro | p.L275P | Q8NEG4 | protein_coding | deleterious(0) | possibly_damaging(0.757) | TCGA-YL-A8SQ-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Hormone Therapy | casodex | SD |
FAM83F | SNV | Missense_Mutation | rs754481227 | c.562N>T | p.Arg188Cys | p.R188C | Q8NEG4 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-BR-4257-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM83F | SNV | Missense_Mutation | novel | c.953N>C | p.Val318Ala | p.V318A | Q8NEG4 | protein_coding | deleterious(0.02) | benign(0.056) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FAM83F | SNV | Missense_Mutation | rs145428025 | c.1036N>T | p.Arg346Trp | p.R346W | Q8NEG4 | protein_coding | deleterious(0) | benign(0.021) | TCGA-BR-6454-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM83F | SNV | Missense_Mutation | c.1031C>T | p.Ala344Val | p.A344V | Q8NEG4 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-BR-7716-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM83F | SNV | Missense_Mutation | c.1325N>A | p.Leu442His | p.L442H | Q8NEG4 | protein_coding | tolerated_low_confidence(0.1) | benign(0.436) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
FAM83F | SNV | Missense_Mutation | rs778728277 | c.1369G>A | p.Ala457Thr | p.A457T | Q8NEG4 | protein_coding | tolerated_low_confidence(0.18) | benign(0.007) | TCGA-BR-8368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM83F | SNV | Missense_Mutation | rs531840891 | c.664N>T | p.Arg222Cys | p.R222C | Q8NEG4 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CD-A487-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | epirubicin | CR |
FAM83F | SNV | Missense_Mutation | rs777110834 | c.959G>A | p.Arg320Gln | p.R320Q | Q8NEG4 | protein_coding | deleterious(0) | possibly_damaging(0.815) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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