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Gene: FAM83E |
Gene summary for FAM83E |
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Gene information | Species | Human | Gene symbol | FAM83E | Gene ID | 54854 |
Gene name | family with sequence similarity 83 member E | |
Gene Alias | FAM83E | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q2M2I3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54854 | FAM83E | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.89e-09 | 5.77e-01 | -0.1808 |
54854 | FAM83E | HTA11_347_2000001011 | Human | Colorectum | AD | 8.96e-13 | 4.77e-01 | -0.1954 |
54854 | FAM83E | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.80e-07 | 1.16e+00 | -0.2196 |
54854 | FAM83E | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.88e-03 | 4.12e-01 | -0.1207 |
54854 | FAM83E | HTA11_83_2000001011 | Human | Colorectum | SER | 3.01e-06 | 6.94e-01 | -0.1526 |
54854 | FAM83E | HTA11_696_2000001011 | Human | Colorectum | AD | 3.67e-24 | 7.71e-01 | -0.1464 |
54854 | FAM83E | HTA11_866_2000001011 | Human | Colorectum | AD | 1.19e-11 | 4.94e-01 | -0.1001 |
54854 | FAM83E | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.32e-06 | 3.86e-01 | -0.059 |
54854 | FAM83E | HTA11_546_2000001011 | Human | Colorectum | AD | 3.60e-03 | 5.39e-01 | -0.0842 |
54854 | FAM83E | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.14e-03 | 4.01e-01 | -0.0177 |
54854 | FAM83E | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.76e-09 | 3.41e-01 | 0.0674 |
54854 | FAM83E | A015-C-203 | Human | Colorectum | FAP | 2.59e-04 | -1.25e-01 | -0.1294 |
54854 | FAM83E | A002-C-205 | Human | Colorectum | FAP | 1.67e-04 | -2.01e-01 | -0.1236 |
54854 | FAM83E | A002-C-114 | Human | Colorectum | FAP | 4.98e-04 | 9.46e-02 | -0.1561 |
54854 | FAM83E | A015-C-104 | Human | Colorectum | FAP | 4.11e-08 | 7.98e-02 | -0.1899 |
54854 | FAM83E | A002-C-016 | Human | Colorectum | FAP | 5.94e-04 | -2.25e-01 | 0.0521 |
54854 | FAM83E | A002-C-116 | Human | Colorectum | FAP | 4.17e-09 | -2.79e-01 | -0.0452 |
54854 | FAM83E | A018-E-020 | Human | Colorectum | FAP | 1.99e-05 | 1.18e-01 | -0.2034 |
54854 | FAM83E | F034 | Human | Colorectum | FAP | 3.70e-03 | -1.34e-01 | -0.0665 |
54854 | FAM83E | CRC-1-8810 | Human | Colorectum | CRC | 9.27e-05 | -3.17e-01 | 0.6257 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM83E | SNV | Missense_Mutation | rs756248260 | c.826G>A | p.Ala276Thr | p.A276T | Q2M2I3 | protein_coding | tolerated(0.29) | benign(0.141) | TCGA-60-2722-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | taxol | PD |
FAM83E | SNV | Missense_Mutation | novel | c.305C>A | p.Pro102His | p.P102H | Q2M2I3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
FAM83E | SNV | Missense_Mutation | novel | c.1153N>T | p.Gly385Cys | p.G385C | Q2M2I3 | protein_coding | deleterious(0) | possibly_damaging(0.75) | TCGA-90-7769-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM83E | SNV | Missense_Mutation | rs267605566 | c.1174N>A | p.Glu392Lys | p.E392K | Q2M2I3 | protein_coding | tolerated(0.06) | benign(0.151) | TCGA-BB-4227-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unspecific | docetaxel | PD |
FAM83E | SNV | Missense_Mutation | novel | c.1340G>C | p.Arg447Thr | p.R447T | Q2M2I3 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.981) | TCGA-CX-7219-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM83E | SNV | Missense_Mutation | c.907N>A | p.Gly303Ser | p.G303S | Q2M2I3 | protein_coding | deleterious(0.05) | benign(0.268) | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM83E | SNV | Missense_Mutation | rs773075907 | c.1076N>A | p.Arg359His | p.R359H | Q2M2I3 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FAM83E | SNV | Missense_Mutation | c.119N>A | p.Ser40Asn | p.S40N | Q2M2I3 | protein_coding | deleterious(0.01) | probably_damaging(0.953) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM83E | SNV | Missense_Mutation | rs749545424 | c.637G>A | p.Val213Met | p.V213M | Q2M2I3 | protein_coding | tolerated(0.11) | benign(0.011) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
FAM83E | SNV | Missense_Mutation | c.950G>A | p.Arg317His | p.R317H | Q2M2I3 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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