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Gene: FAM81B |
Gene summary for FAM81B |
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Gene information | Species | Human | Gene symbol | FAM81B | Gene ID | 153643 |
Gene name | family with sequence similarity 81 member B | |
Gene Alias | FAM81B | |
Cytomap | 5q15 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96LP2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
153643 | FAM81B | RNA-P6T1-P6T1-2 | Human | Lung | MIAC | 4.12e-03 | 5.90e-01 | -0.0186 |
153643 | FAM81B | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 3.47e-02 | 4.97e-01 | -0.0296 |
153643 | FAM81B | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 5.54e-03 | 5.18e-01 | -0.0263 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM81B | SNV | Missense_Mutation | novel | c.1006C>A | p.Leu336Met | p.L336M | Q96LP2 | protein_coding | tolerated(0.07) | possibly_damaging(0.839) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM81B | SNV | Missense_Mutation | novel | c.261N>T | p.Lys87Asn | p.K87N | Q96LP2 | protein_coding | deleterious(0.01) | probably_damaging(0.913) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM81B | SNV | Missense_Mutation | c.1229N>G | p.Phe410Cys | p.F410C | Q96LP2 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM81B | SNV | Missense_Mutation | rs756787447 | c.1102C>G | p.Gln368Glu | p.Q368E | Q96LP2 | protein_coding | tolerated(0.18) | benign(0.007) | TCGA-E6-A2P9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM81B | SNV | Missense_Mutation | novel | c.1091N>C | p.Phe364Ser | p.F364S | Q96LP2 | protein_coding | tolerated(0.16) | probably_damaging(0.915) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM81B | SNV | Missense_Mutation | rs369548823 | c.1293N>T | p.Glu431Asp | p.E431D | Q96LP2 | protein_coding | tolerated(0.42) | possibly_damaging(0.831) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
FAM81B | SNV | Missense_Mutation | novel | c.540N>G | p.Ile180Met | p.I180M | Q96LP2 | protein_coding | tolerated(0.19) | benign(0.127) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM81B | SNV | Missense_Mutation | novel | c.770N>G | p.Lys257Arg | p.K257R | Q96LP2 | protein_coding | deleterious(0.05) | probably_damaging(0.994) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM81B | SNV | Missense_Mutation | c.466N>T | p.Ala156Ser | p.A156S | Q96LP2 | protein_coding | tolerated(0.08) | probably_damaging(0.987) | TCGA-DD-A3A9-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
FAM81B | SNV | Missense_Mutation | novel | c.107N>A | p.Ala36Glu | p.A36E | Q96LP2 | protein_coding | deleterious_low_confidence(0.02) | benign(0.017) | TCGA-05-4432-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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