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Gene: FAM64A |
Gene summary for FAM64A |
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Gene information | Species | Human | Gene symbol | FAM64A | Gene ID | 54478 |
Gene name | PICALM interacting mitotic regulator | |
Gene Alias | CATS | |
Cytomap | 17p13.2 | |
Gene Type | protein-coding | GO ID | GO:0007049 | UniProtAcc | A0A0S2Z5F0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54478 | FAM64A | P2T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.56e-01 | 0.1177 |
54478 | FAM64A | P4T-E | Human | Esophagus | ESCC | 8.33e-13 | 5.16e-01 | 0.1323 |
54478 | FAM64A | P9T-E | Human | Esophagus | ESCC | 1.88e-05 | 1.80e-01 | 0.1131 |
54478 | FAM64A | P10T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.62e-01 | 0.116 |
54478 | FAM64A | P16T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.44e-01 | 0.1153 |
54478 | FAM64A | P21T-E | Human | Esophagus | ESCC | 1.47e-14 | 5.39e-01 | 0.1617 |
54478 | FAM64A | P22T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.26e-01 | 0.1236 |
54478 | FAM64A | P24T-E | Human | Esophagus | ESCC | 4.44e-08 | 2.71e-01 | 0.1287 |
54478 | FAM64A | P28T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.26e-01 | 0.1149 |
54478 | FAM64A | P30T-E | Human | Esophagus | ESCC | 2.13e-03 | 3.41e-01 | 0.137 |
54478 | FAM64A | P31T-E | Human | Esophagus | ESCC | 2.06e-08 | 3.32e-01 | 0.1251 |
54478 | FAM64A | P32T-E | Human | Esophagus | ESCC | 9.67e-18 | 5.76e-01 | 0.1666 |
54478 | FAM64A | P37T-E | Human | Esophagus | ESCC | 1.42e-10 | 3.14e-01 | 0.1371 |
54478 | FAM64A | P52T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.78e-01 | 0.1555 |
54478 | FAM64A | P54T-E | Human | Esophagus | ESCC | 2.11e-02 | 1.07e-01 | 0.0975 |
54478 | FAM64A | P61T-E | Human | Esophagus | ESCC | 2.42e-03 | 1.36e-01 | 0.099 |
54478 | FAM64A | P62T-E | Human | Esophagus | ESCC | 2.57e-02 | 1.58e-01 | 0.1302 |
54478 | FAM64A | P74T-E | Human | Esophagus | ESCC | 3.33e-12 | 8.86e-01 | 0.1479 |
54478 | FAM64A | P76T-E | Human | Esophagus | ESCC | 9.20e-06 | 3.77e-01 | 0.1207 |
54478 | FAM64A | P79T-E | Human | Esophagus | ESCC | 9.53e-09 | 2.84e-01 | 0.1154 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM64A | SNV | Missense_Mutation | rs773771421 | c.484N>T | p.Arg162Cys | p.R162C | Q9BSJ6 | protein_coding | tolerated(0.14) | benign(0.005) | TCGA-IQ-A61J-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
FAM64A | SNV | Missense_Mutation | rs369882202 | c.485N>A | p.Arg162His | p.R162H | Q9BSJ6 | protein_coding | tolerated(0.32) | benign(0.005) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
FAM64A | SNV | Missense_Mutation | c.175N>A | p.Val59Ile | p.V59I | Q9BSJ6 | protein_coding | deleterious(0.02) | possibly_damaging(0.781) | TCGA-BR-4280-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
FAM64A | SNV | Missense_Mutation | rs752671456 | c.439N>A | p.Ala147Thr | p.A147T | Q9BSJ6 | protein_coding | tolerated(0.77) | benign(0) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
FAM64A | SNV | Missense_Mutation | rs144086256 | c.361N>T | p.Arg121Trp | p.R121W | Q9BSJ6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM64A | SNV | Missense_Mutation | c.109N>A | p.Glu37Lys | p.E37K | Q9BSJ6 | protein_coding | tolerated(0.3) | benign(0.305) | TCGA-DJ-A13P-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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